Select a medication above to begin.
Rezdiffra
resmetirom
Adult Dosing .
Dosage forms: TAB: 60 mg, 80 mg, 100 mg
metabolic dysfxn-associated steatohepatitis, pts w/ stage F2-F3 fibrosis
- [<100 kg]
- Dose: 80 mg PO qd; Info: use ABW to calculate dose
- [>100 kg]
- Dose: 100 mg PO qd; Info: use ABW to calculate dose
renal dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hepatic impairment, Child-Pugh Class B-C
Drug Interactions .
Overview
resmetirom
THR-beta agonist
- CYP2C8 substrate
- OATP1B1 substrate
- OATP1B3 substrate
- CYP2C8 inhibitor, weak
- BCRP inhibitor
- OATP1B1 inhibitor, weak
- OATP1B3 inhibitor, weak
Contraindicated
- grazoprevir
Avoid/Use Alternative
- alpelisib
- asciminib
- atazanavir
- atrasentan
- belumosudil
- bempedoic acid
- brincidofovir
- ceftobiprole
- cladribine oral
- clarithromycin
- cobicistat
- cyclosporine
- darolutamide
- darunavir
- elagolix
- elexacaftor/tezacaftor/ivacaftor
- eltrombopag
- eluxadoline
- enasidenib
- encorafenib
- erythromycin
- fostemsavir
- gemfibrozil
- glecaprevir
- irbesartan
- leflunomide
- leniolisib
- letermovir
- lopinavir/ritonavir
- midostaurin
- pazopanib
- pibrentasvir
- pretomanid
- rifampin
- ritonavir
- sacubitril
- teriflunomide
- tipranavir
- topotecan
- trofinetide
- vadadustat
- velpatasvir
- voclosporin
- voxilaprevir
- zavegepant
Monitor/Modify Tx
- amiodarone
- atogepant
- atorvastatin
- clopidogrel
- deferasirox
- fluvastatin
- glyburide
- imatinib
- irinotecan
- lapatinib
- lovastatin
- methotrexate
- mitoxantrone
- momelotinib
- nateglinide
- paclitaxel
- pioglitazone
- pirtobrutinib
- pitavastatin
- pravastatin
- red yeast rice
- repaglinide
- riociguat
- rosiglitazone
- rosuvastatin
- selpercatinib
- simvastatin
- talazoparib
- tenofovir alafenamide
- tenofovir disoproxil
- ubrogepant
Caution Advised
- bosentan
- seladelpar
- sulfasalazine
Adverse Reactions .
Serious Reactions
- hepatotoxicity
- hepatitis, autoimmune-like
- cholelithiasis
- cholecystitis
- obstructive pancreatitis
Common Reactions
- diarrhea
- nausea
- ALT elevated
- AST elevated
- pruritus
- vomiting
- constipation
- abdominal pain
- dizziness
- bilirubin elevated
- T4 levels decr.
Safety/Monitoring .
Monitoring Parameters
LFTs at baseline and during tx
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; risk of fetal harm, incl. embryo-fetal death and decr. fetal wt, based on animal data at 3.5x MRHD
Pregnancy Reporting
report any suspected fetal exposure to Madrigal Pharmaceuticals at 1-800-905-0324 or www.madrigalpharma.com/contact/
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver; CYP450: 2C8 substrate
Excretion: feces 67% (none to minimally unchanged), urine 24% (1% unchanged); Half-life: 4.5h
Subclass: Metabolic Dysfunction-Associated Steatohepatitis
Mechanism of Action
stimulates thyroid hormone receptor-beta, reducing intrahepatic triglycerides
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.