Luvox

Overview

fluvoxamine

SSRI

• CYP2D6 substrate
• CYP1A2 inhibitor, strong
• CYP2C8 inhibitor, weak
• CYP2C9 inhibitor, weak
• CYP2C19 inhibitor, strong
• CYP2D6 inhibitor, weak
• CYP3A4 inhibitor, weak
• P-gp inhibitor, weak
• antiplatelet effects
• CNS depression
• hyponatremia
• lowers seizure threshold
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• alosetron
Luvox (fluvoxamine)

+

alosetron

1 interaction

Contraindicated

fluvoxamine + alosetron

contraindicated: combo may incr. alosetron levels, risk of adverse effects (hepatic metab. inhibited)

• cisapride
Luvox (fluvoxamine)

+

cisapride

1 interaction

Contraindicated

fluvoxamine + cisapride

contraindicated: combo may incr. cisapride levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• colchicine
Luvox (fluvoxamine)

+

colchicine

1 interaction

Contraindicated

fluvoxamine + colchicine

CV RISK REDUCTION: consider monitoring CK, myopathy s/sx; GOUT OR FMF: contraindicated in pts w/ renal or hepatic impairment; otherwise, use alternative or consider decr. colchicine dose during and x14 days after fluvoxamine use: combo may incr. colchicine levels, risk of myopathy, rhabdomyolysis, other life-threatening toxicity (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• fezolinetant
Luvox (fluvoxamine)

+

fezolinetant

1 interaction

Contraindicated

fluvoxamine + fezolinetant

contraindicated: combo may incr. fezolinetant levels, risk of adverse effects (hepatic metab. inhibited)

• isocarboxazid
Luvox (fluvoxamine)

+

isocarboxazid

1 interaction

Contraindicated

fluvoxamine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or fluvoxamine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• linezolid
Luvox (fluvoxamine)

+

linezolid

1 interaction

Contraindicated

fluvoxamine + linezolid

contraindicated; hold fluvoxamine if urgent use; monitor sodium, serotonin syndrome sx x2wk after fluvoxamine D/C or 24h after last linezolid dose; may resume fluvoxamine 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, hyponatremia (additive effects, linezolid reversibly inhibits monoamine oxidase)

• mavacamten
Luvox (fluvoxamine)

+

mavacamten

1 interaction

Contraindicated

fluvoxamine + mavacamten

contraindicated: combo may incr. mavacamten levels, risk of heart failure, other adverse effects (hepatic metab. inhibited)

• methylene blue injection
Luvox (fluvoxamine)

+

methylene blue injection

1 interaction

Contraindicated

fluvoxamine + methylene blue injection

contraindicated; hold fluvoxamine if emergency use; monitor serotonin syndrome sx x2wk or up to 24h after last methylene blue dose; may resume fluvoxamine 24h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• phenelzine
Luvox (fluvoxamine)

+

phenelzine

1 interaction

Contraindicated

fluvoxamine + phenelzine

contraindicated w/in 14 days of phenelzine or fluvoxamine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• pimozide
Luvox (fluvoxamine)

+

pimozide

1 interaction

Contraindicated

fluvoxamine + pimozide

contraindicated: combo may incr. pimozide levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• ramelteon
Luvox (fluvoxamine)

+

ramelteon

1 interaction

Contraindicated

fluvoxamine + ramelteon

contraindicated: combo may incr. ramelteon levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• selegiline transdermal
Luvox (fluvoxamine)

+

selegiline transdermal

1 interaction

Contraindicated

fluvoxamine + selegiline transdermal

contraindicated w/in 14 days of selegiline or fluvoxamine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• thioridazine
Luvox (fluvoxamine)

+

thioridazine

1 interaction

Contraindicated

fluvoxamine + thioridazine

contraindicated: combo may incr. thioridazine levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• tizanidine
Luvox (fluvoxamine)

+

tizanidine

1 interaction

Contraindicated

fluvoxamine + tizanidine

contraindicated: combo may incr. tizanidine levels, risk of hypotension (incl. orthostasis, syncope), bradycardia, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• tranylcypromine
Luvox (fluvoxamine)

+

tranylcypromine

1 interaction

Contraindicated

fluvoxamine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or fluvoxamine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Avoid/Use Alternative

• 5-HTP
Luvox (fluvoxamine)

+

5-HTP

1 interaction

Avoid/Use Alternative

fluvoxamine + 5-HTP

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• abrocitinib
Luvox (fluvoxamine)

+

abrocitinib

1 interaction

Avoid/Use Alternative

fluvoxamine + abrocitinib

avoid combo if also combined w/ moderate or strong CYP2C9 inhibitor; otherwise, monitor platelets, bleeding s/sx, and decr. abrocitinib dose to 50 mg qd; may incr. to max 100 mg qd if inadequate response after 12wk: combo may incr. abrocitinib and active metabolite levels, risk of serious infection, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• aldesleukin
Luvox (fluvoxamine)

+

aldesleukin

1 interaction

Avoid/Use Alternative

fluvoxamine + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, seizures (additive effects)

• alfentanil
Luvox (fluvoxamine)

+

alfentanil

1 interaction

Avoid/Use Alternative

fluvoxamine + alfentanil

use alternative or monitor BP, resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs: combo may incr. alfentanil levels, risk of profound CNS and resp. depression, psychomotor impairment, delayed recovery from anesthesia, serotonin syndrome, hypotension, other adverse effects (hepatic metab. inhibited, additive effects)

• almotriptan
Luvox (fluvoxamine)

+

almotriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + almotriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• alprazolam
Luvox (fluvoxamine)

+

alprazolam

1 interaction

Avoid/Use Alternative

fluvoxamine + alprazolam

use alternative or monitor resp. rate; decr. alprazolam start dose by at least 50%: combo may incr. alprazolam levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• amifampridine
Luvox (fluvoxamine)

+

amifampridine

1 interaction

Avoid/Use Alternative

fluvoxamine + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amitriptyline
Luvox (fluvoxamine)

+

amitriptyline

1 interaction

Avoid/Use Alternative

fluvoxamine + amitriptyline

use alternative or monitor amitriptyline levels, ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. amitriptyline levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• amoxapine
Luvox (fluvoxamine)

+

amoxapine

1 interaction

Avoid/Use Alternative

fluvoxamine + amoxapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amphetamine
Luvox (fluvoxamine)

+

amphetamine

1 interaction

Avoid/Use Alternative

fluvoxamine + amphetamine

use alternative or decr. amphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• apixaban
Luvox (fluvoxamine)

+

apixaban

1 interaction

Avoid/Use Alternative

fluvoxamine + apixaban

monitor bleeding s/sx; if also combined w/ strong CYP3A4 inhibitor, decr. apixaban dose by 50% or avoid combo if already on 2.5 mg bid; if also combined w/ moderate CYP3A4 inhibitor, consider decr. apixaban dose: combo may incr. apixaban levels, risk of bleeding (incl. life-threatening), other adverse effects (P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bendamustine
Luvox (fluvoxamine)

+

bendamustine

1 interaction

Avoid/Use Alternative

fluvoxamine + bendamustine

consider alternatives: combo may incr. bendamustine levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• bosentan
Luvox (fluvoxamine)

+

bosentan

1 interaction

Avoid/Use Alternative

fluvoxamine + bosentan

avoid combo if also combined w/ strong-mod CYP3A4 inhibitor; otherwise caution advised: combo may incr. bosentan levels, risk of adverse effects (hepatic metab. inhibited)

• bromocriptine
Luvox (fluvoxamine)

+

bromocriptine

1 interaction

Avoid/Use Alternative

fluvoxamine + bromocriptine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• buprenorphine
Luvox (fluvoxamine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

fluvoxamine + buprenorphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• buspirone
Luvox (fluvoxamine)

+

buspirone

1 interaction

Avoid/Use Alternative

fluvoxamine + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• butalbital
Luvox (fluvoxamine)

+

butalbital

1 interaction

Avoid/Use Alternative

fluvoxamine + butalbital

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• butorphanol
Luvox (fluvoxamine)

+

butorphanol

1 interaction

Avoid/Use Alternative

fluvoxamine + butorphanol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• carbamazepine
Luvox (fluvoxamine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

fluvoxamine + carbamazepine

use alternative or monitor carbamazepine levels, sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. carbamazepine levels, risk of hyponatremia, seizures, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• citalopram
Luvox (fluvoxamine)

+

citalopram

1 interaction

Avoid/Use Alternative

fluvoxamine + citalopram

avoid combo: combo may incr. citalopram levels, risk of QT prolongation, cardiac arrhythmias, hyponatremia, CNS depression, psychomotor impairment, serotonin syndrome, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• clomipramine
Luvox (fluvoxamine)

+

clomipramine

1 interaction

Avoid/Use Alternative

fluvoxamine + clomipramine

use alternative or monitor ECG, sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. clomipramine levels, risk of QT prolongation, cardiac arrhythmias, serotonin syndrome, hyponatremia, CNS depression, psychomotor impairment, seizures, other adverse effects (hepatic metab. inhibited, additive effects)

• clonidine
Luvox (fluvoxamine)

+

clonidine

1 interaction

Avoid/Use Alternative

fluvoxamine + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clopidogrel
Luvox (fluvoxamine)

+

clopidogrel

1 interaction

Avoid/Use Alternative

fluvoxamine + clopidogrel

avoid combo: combo may incr. risk of bleeding, incl. life-threatening; may decr. clopidogrel active metabolite levels, efficacy (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; hepatic metab. inhibited, decr. conversion of clopidogrel to active metabolite)

• cocaine
Luvox (fluvoxamine)

+

cocaine

1 interaction

Avoid/Use Alternative

fluvoxamine + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Luvox (fluvoxamine)

+

codeine

1 interaction

Avoid/Use Alternative

fluvoxamine + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• cyclobenzaprine
Luvox (fluvoxamine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

fluvoxamine + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• dabigatran
Luvox (fluvoxamine)

+

dabigatran

1 interaction

Avoid/Use Alternative

fluvoxamine + dabigatran

monitor bleeding s/sx; ATRIAL FIBRILLATION: avoid combo if CrCl <30 mL/min; OTHER INDICATIONS: avoid combo if CrCl <50 mL/min; if dabigatran use for DVT/PE prophylaxis post-hip replacement and CrCl >50 mL/min, consider separating admin. at least 2h apart: combo may incr. dabigatran levels, risk of bleeding (incl. life-threatening), other adverse effects (P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• desipramine
Luvox (fluvoxamine)

+

desipramine

1 interaction

Avoid/Use Alternative

fluvoxamine + desipramine

use alternative or monitor desipramine levels, ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. desipramine levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• desvenlafaxine
Luvox (fluvoxamine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

fluvoxamine + desvenlafaxine

avoid combo: combo may incr. risk of hyponatremia, CNS depression, psychomotor impairment, serotonin syndrome, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dexmethylphenidate
Luvox (fluvoxamine)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

fluvoxamine + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
Luvox (fluvoxamine)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

fluvoxamine + dextroamphetamine

use alternative or decr. dextroamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
Luvox (fluvoxamine)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

fluvoxamine + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diazepam
Luvox (fluvoxamine)

+

diazepam

1 interaction

Avoid/Use Alternative

fluvoxamine + diazepam

use alternative or monitor resp. rate; consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• dihydrocodeine
Luvox (fluvoxamine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

fluvoxamine + dihydrocodeine

use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. dihydrocodeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite dihydromorphine levels, efficacy (hepatic metab. inhibited, decr. conversion to dihydromorphine, additive effects)

• dihydroergotamine
Luvox (fluvoxamine)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

fluvoxamine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. dihydroergotamine levels, risk of severe vasospasm, ischemia, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• doxepin
Luvox (fluvoxamine)

+

doxepin

1 interaction

Avoid/Use Alternative

fluvoxamine + doxepin

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. doxepin levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• doxepin topical
Luvox (fluvoxamine)

+

doxepin topical

1 interaction

Avoid/Use Alternative

fluvoxamine + doxepin topical

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. doxepin levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• doxylamine
Luvox (fluvoxamine)

+

doxylamine

1 interaction

Avoid/Use Alternative

fluvoxamine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• duloxetine
Luvox (fluvoxamine)

+

duloxetine

1 interaction

Avoid/Use Alternative

fluvoxamine + duloxetine

avoid combo: combo may incr. duloxetine levels, risk of hyponatremia, serotonin syndrome, CNS depression, psychomotor impairment, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
Luvox (fluvoxamine)

+

edoxaban

1 interaction

Avoid/Use Alternative

fluvoxamine + edoxaban

use alternative or monitor bleeding s/sx: combo may incr. edoxaban levels, risk of bleeding (incl. life-threatening), other adverse effects (P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eletriptan
Luvox (fluvoxamine)

+

eletriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + eletriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• eliglustat
Luvox (fluvoxamine)

+

eliglustat

1 interaction

Avoid/Use Alternative

fluvoxamine + eliglustat

CYP2D6 EXTENSIVE OR INTERMEDIATE METABOLIZERS: monitor ECG; consider decr. eliglustat dose to 84 mg qd; CYP2D6 POOR METABOLIZERS: avoid combo: combo may incr. eliglustat levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• enoxaparin
Luvox (fluvoxamine)

+

enoxaparin

1 interaction

Avoid/Use Alternative

fluvoxamine + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ensartinib
Luvox (fluvoxamine)

+

ensartinib

1 interaction

Avoid/Use Alternative

fluvoxamine + ensartinib

avoid combo: combo may incr. ensartinib levels, risk of bradycardia, hyperglycemia, other adverse effects (P-gp-mediated transport possibly inhibited)

• ergotamine
Luvox (fluvoxamine)

+

ergotamine

1 interaction

Avoid/Use Alternative

fluvoxamine + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. ergotamine levels, risk of ergot toxicity, severe vasospasm, ischemia, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• erlotinib
Luvox (fluvoxamine)

+

erlotinib

1 interaction

Avoid/Use Alternative

fluvoxamine + erlotinib

if also combined w/ strong CYP3A4 inhibitor, use alternative or consider decr. erlotinib dose by 50 mg/day decrements; otherwise, monitor bleeding s/sx: combo may incr. erlotinib levels, risk of GI or other bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• escitalopram
Luvox (fluvoxamine)

+

escitalopram

1 interaction

Avoid/Use Alternative

fluvoxamine + escitalopram

avoid combo: combo may incr. escitalopram levels, risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• ethanol
Luvox (fluvoxamine)

+

ethanol

1 interaction

Avoid/Use Alternative

fluvoxamine + ethanol

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenfluramine
Luvox (fluvoxamine)

+

fenfluramine

1 interaction

Avoid/Use Alternative

fluvoxamine + fenfluramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• fentanyl
Luvox (fluvoxamine)

+

fentanyl

1 interaction

Avoid/Use Alternative

fluvoxamine + fentanyl

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. fentanyl levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• fluoxetine
Luvox (fluvoxamine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

fluvoxamine + fluoxetine

avoid combo: combo may incr. fluvoxamine levels, risk of serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, duplicate tx)

• fluvoxamine
Luvox (fluvoxamine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

fluvoxamine + fluvoxamine

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• fondaparinux
Luvox (fluvoxamine)

+

fondaparinux

1 interaction

Avoid/Use Alternative

fluvoxamine + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• frovatriptan
Luvox (fluvoxamine)

+

frovatriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + frovatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• futibatinib
Luvox (fluvoxamine)

+

futibatinib

1 interaction

Avoid/Use Alternative

fluvoxamine + futibatinib

avoid combo if also combined w/ strong CYP3A4 inhibitor; otherwise, monitor phosphate: combo may incr. futibatinib levels, risk of hyperphosphatemia, other adverse effects (P-gp-mediated transport inhibited)

• gepirone
Luvox (fluvoxamine)

+

gepirone

1 interaction

Avoid/Use Alternative

fluvoxamine + gepirone

use alternative or monitor ECG, electrolytes, serotonin syndrome sx, especially during initiation/titration: combo may incr. gepirone levels, risk of QT prolongation, cardiac arrhythmias, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• granisetron
Luvox (fluvoxamine)

+

granisetron

1 interaction

Avoid/Use Alternative

fluvoxamine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Luvox (fluvoxamine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

fluvoxamine + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, ECG, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. hydrocodone levels, risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• hydromorphone
Luvox (fluvoxamine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

fluvoxamine + hydromorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• imipramine
Luvox (fluvoxamine)

+

imipramine

1 interaction

Avoid/Use Alternative

fluvoxamine + imipramine

use alternative or monitor imipramine levels, serotonin syndrome sx, especially during initiation/titration: combo may incr. imipramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• iohexol
Luvox (fluvoxamine)

+

iohexol

1 interaction

Avoid/Use Alternative

fluvoxamine + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isoniazid
Luvox (fluvoxamine)

+

isoniazid

1 interaction

Avoid/Use Alternative

fluvoxamine + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• kava
Luvox (fluvoxamine)

+

kava

1 interaction

Avoid/Use Alternative

fluvoxamine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Luvox (fluvoxamine)

+

kratom

1 interaction

Avoid/Use Alternative

fluvoxamine + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lasmiditan
Luvox (fluvoxamine)

+

lasmiditan

1 interaction

Avoid/Use Alternative

fluvoxamine + lasmiditan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• levomilnacipran
Luvox (fluvoxamine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

fluvoxamine + levomilnacipran

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• levorphanol
Luvox (fluvoxamine)

+

levorphanol

1 interaction

Avoid/Use Alternative

fluvoxamine + levorphanol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• lisdexamfetamine
Luvox (fluvoxamine)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

fluvoxamine + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
Luvox (fluvoxamine)

+

lithium

1 interaction

Avoid/Use Alternative

fluvoxamine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• meperidine
Luvox (fluvoxamine)

+

meperidine

1 interaction

Avoid/Use Alternative

fluvoxamine + meperidine

use alternative or monitor resp. rate, ECG, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. meperidine levels, risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• metaxalone
Luvox (fluvoxamine)

+

metaxalone

1 interaction

Avoid/Use Alternative

fluvoxamine + metaxalone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Luvox (fluvoxamine)

+

methadone

1 interaction

Avoid/Use Alternative

fluvoxamine + methadone

use alternative or monitor resp. rate, ECG, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. methadone levels, risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• methamphetamine
Luvox (fluvoxamine)

+

methamphetamine

1 interaction

Avoid/Use Alternative

fluvoxamine + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylene blue oral
Luvox (fluvoxamine)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

fluvoxamine + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Luvox (fluvoxamine)

+

methylergonovine

1 interaction

Avoid/Use Alternative

fluvoxamine + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. methylergonovine levels, risk of ergot toxicity, severe vasospasm, ischemia, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• methylphenidate
Luvox (fluvoxamine)

+

methylphenidate

1 interaction

Avoid/Use Alternative

fluvoxamine + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. fluvoxamine levels, risk of serotonin syndrome, other adverse effects (mechanism unknown, hepatic metab. possibly inhibited, additive effects)

• metoclopramide
Luvox (fluvoxamine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

fluvoxamine + metoclopramide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• midazolam
Luvox (fluvoxamine)

+

midazolam

1 interaction

Avoid/Use Alternative

fluvoxamine + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. midazolam and active metabolite levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• milnacipran
Luvox (fluvoxamine)

+

milnacipran

1 interaction

Avoid/Use Alternative

fluvoxamine + milnacipran

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mirtazapine
Luvox (fluvoxamine)

+

mirtazapine

1 interaction

Avoid/Use Alternative

fluvoxamine + mirtazapine

use alternative or monitor ECG, sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. mirtazapine levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hyponatremia, other adverse effects (hepatic metab. inhibited, additive effects)

• morphine
Luvox (fluvoxamine)

+

morphine

1 interaction

Avoid/Use Alternative

fluvoxamine + morphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (P-gp-mediated transport inhibited, additive effects)

• nalbuphine
Luvox (fluvoxamine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

fluvoxamine + nalbuphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• naratriptan
Luvox (fluvoxamine)

+

naratriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + naratriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nefazodone
Luvox (fluvoxamine)

+

nefazodone

1 interaction

Avoid/Use Alternative

fluvoxamine + nefazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• neratinib
Luvox (fluvoxamine)

+

neratinib

1 interaction

Avoid/Use Alternative

fluvoxamine + neratinib

avoid combo if also combined w/ strong-mod CYP3A4 inhibitor; otherwise, caution advised: combo may incr. neratinib levels, risk of adverse effects (P-gp-mediated transport inhibited)

• nortriptyline
Luvox (fluvoxamine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

fluvoxamine + nortriptyline

use alternative or monitor nortriptyline levels, serotonin syndrome sx, especially during initiation/titration: combo may incr. nortriptyline levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• oliceridine
Luvox (fluvoxamine)

+

oliceridine

1 interaction

Avoid/Use Alternative

fluvoxamine + oliceridine

use alternative or monitor resp. rate, ECG, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. oliceridine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hypotension, other adverse effects (hepatic metab. inhibited, additive effects)

• ondansetron
Luvox (fluvoxamine)

+

ondansetron

1 interaction

Avoid/Use Alternative

fluvoxamine + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Luvox (fluvoxamine)

+

opium

1 interaction

Avoid/Use Alternative

fluvoxamine + opium

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxybate
Luvox (fluvoxamine)

+

oxybate

1 interaction

Avoid/Use Alternative

fluvoxamine + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Luvox (fluvoxamine)

+

oxycodone

1 interaction

Avoid/Use Alternative

fluvoxamine + oxycodone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. fluvoxamine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. oxycodone levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• oxymorphone
Luvox (fluvoxamine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

fluvoxamine + oxymorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. fluvoxamine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• palonosetron
Luvox (fluvoxamine)

+

palonosetron

1 interaction

Avoid/Use Alternative

fluvoxamine + palonosetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• paroxetine
Luvox (fluvoxamine)

+

paroxetine

1 interaction

Avoid/Use Alternative

fluvoxamine + paroxetine

avoid combo: combo may incr. fluvoxamine levels, risk of bleeding (incl. life-threatening), hyponatremia, serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• pentazocine
Luvox (fluvoxamine)

+

pentazocine

1 interaction

Avoid/Use Alternative

fluvoxamine + pentazocine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• phentermine
Luvox (fluvoxamine)

+

phentermine

1 interaction

Avoid/Use Alternative

fluvoxamine + phentermine

avoid combo, especially w/ phentermine dose >15 mg: combo may incr. risk of cardiovascular and CNS stimulatory effects (mechanism unknown)

• pirfenidone
Luvox (fluvoxamine)

+

pirfenidone

1 interaction

Avoid/Use Alternative

fluvoxamine + pirfenidone

consider alternative or decr. pirfenidone dose to 267 mg tid: combo may incr. pirfenidone levels, risk of adverse effects (hepatic metab. inhibited)

• pomalidomide
Luvox (fluvoxamine)

+

pomalidomide

1 interaction

Avoid/Use Alternative

fluvoxamine + pomalidomide

use alternative or monitor CBC; decr. pomalidomide dose to 2mg: combo may incr. pomalidomide levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• pralsetinib
Luvox (fluvoxamine)

+

pralsetinib

1 interaction

Avoid/Use Alternative

fluvoxamine + pralsetinib

use alternative or monitor bleeding s/sx, consider monitoring ECG, electrolytes and decr. pralsetinib dose as follows: if on pralsetinib 400 mg qd or 300 mg qd, decr. to 200 mg qd; if on pralsetinib 200 mg qd, decr. to 100 mg qd: combo may incr. pralsetinib levels, risk of QT prolongation, cardiac arrhythmias, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• procarbazine
Luvox (fluvoxamine)

+

procarbazine

1 interaction

Avoid/Use Alternative

fluvoxamine + procarbazine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects, procarbazine inhibits monoamine oxidase)

• promethazine
Luvox (fluvoxamine)

+

promethazine

1 interaction

Avoid/Use Alternative

fluvoxamine + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, seizures (additive effects)

• propafenone
Luvox (fluvoxamine)

+

propafenone

1 interaction

Avoid/Use Alternative

fluvoxamine + propafenone

avoid combo: combo may incr. propafenone levels, risk of QT prolongation, cardiac arrhythmias, hypotension, other adverse effects (hepatic metab. inhibited)

• protriptyline
Luvox (fluvoxamine)

+

protriptyline

1 interaction

Avoid/Use Alternative

fluvoxamine + protriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• rasagiline
Luvox (fluvoxamine)

+

rasagiline

1 interaction

Avoid/Use Alternative

fluvoxamine + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. rasagiline levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• relugolix
Luvox (fluvoxamine)

+

relugolix

1 interaction

Avoid/Use Alternative

fluvoxamine + relugolix

PROSTATE CANCER: may hold relugolix if fluvoxamine tx up to 2wk; otherwise, use alternative or monitor ECG, electrolytes and admin. relugolix at least 6h before fluvoxamine; FIBROID-ASSOC. BLEEDING: use alternative or admin. relugolix at least 6h before fluvoxamine: combo may incr. relugolix levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (gut P-gp-mediated transport inhibited)

• remifentanil
Luvox (fluvoxamine)

+

remifentanil

1 interaction

Avoid/Use Alternative

fluvoxamine + remifentanil

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• repotrectinib
Luvox (fluvoxamine)

+

repotrectinib

1 interaction

Avoid/Use Alternative

fluvoxamine + repotrectinib

avoid combo: combo may incr. repotrectinib levels, risk of CNS depression, psychomotor impairment, other adverse reactions (hepatic metab. inhibited, P-gp-mediated transport inhibited, additive effects)

• rivaroxaban
Luvox (fluvoxamine)

+

rivaroxaban

1 interaction

Avoid/Use Alternative

fluvoxamine + rivaroxaban

avoid combo if also combined w/ strong CYP3A4 inhibitor; use alternative if CrCl <80 and combined w/ moderate CYP3A4 inhibitor; otherwise, monitor bleeding s/sx: combo may incr. rivaroxaban levels, risk of bleeding (incl. life-threatening), other adverse effects (P-gp-mediated transport inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• rizatriptan
Luvox (fluvoxamine)

+

rizatriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + rizatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Luvox (fluvoxamine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

fluvoxamine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• SAMe
Luvox (fluvoxamine)

+

SAMe

1 interaction

Avoid/Use Alternative

fluvoxamine + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• selegiline
Luvox (fluvoxamine)

+

selegiline

1 interaction

Avoid/Use Alternative

fluvoxamine + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• sertraline
Luvox (fluvoxamine)

+

sertraline

1 interaction

Avoid/Use Alternative

fluvoxamine + sertraline

avoid combo: combo may incr. sertraline levels, risk of QT prolongation, cardiac arrhythmias, serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• simvastatin
Luvox (fluvoxamine)

+

simvastatin

1 interaction

Avoid/Use Alternative

fluvoxamine + simvastatin

use alternative or monitor CK, myopathy sx; adjust max simvastatin dose to 20 mg/day: combo may incr. simvastatin levels, risk of myopathy, rhabdomyolysis, other adverse effects (hepatic metab. inhibited)

• sirolimus albumin-bound
Luvox (fluvoxamine)

+

sirolimus albumin-bound

1 interaction

Avoid/Use Alternative

fluvoxamine + sirolimus albumin-bound

avoid combo: combo may incr. sirolimus albumin-bound levels, risk of serious infection, myelosuppression, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• St. John's wort
Luvox (fluvoxamine)

+

St. John's wort

1 interaction

Avoid/Use Alternative

fluvoxamine + St. John's wort

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sufentanil
Luvox (fluvoxamine)

+

sufentanil

1 interaction

Avoid/Use Alternative

fluvoxamine + sufentanil

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. sufentanil start dose or frequency, consider decr. fluvoxamine dose, use lowest effective doses: combo may incr. sufentanil levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• sumatriptan
Luvox (fluvoxamine)

+

sumatriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + sumatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• tapentadol
Luvox (fluvoxamine)

+

tapentadol

1 interaction

Avoid/Use Alternative

fluvoxamine + tapentadol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• tasimelteon
Luvox (fluvoxamine)

+

tasimelteon

1 interaction

Avoid/Use Alternative

fluvoxamine + tasimelteon

avoid combo: combo may incr. tasimelteon levels, risk of adverse effects; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. inhibited; additive effects)

• thalidomide
Luvox (fluvoxamine)

+

thalidomide

1 interaction

Avoid/Use Alternative

fluvoxamine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• topotecan
Luvox (fluvoxamine)

+

topotecan

1 interaction

Avoid/Use Alternative

fluvoxamine + topotecan

avoid combo w/ oral topotecan: combo may incr. topotecan levels, risk of serious infection, myelosuppression, other adverse effects (gut P-gp-mediated transport inhibited)

• tramadol
Luvox (fluvoxamine)

+

tramadol

1 interaction

Avoid/Use Alternative

fluvoxamine + tramadol

use alternative or monitor sodium, resp. rate, ECG, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. tramadol levels, risk of profound CNS and resp. depression, psychomotor impairment, seizures, serotonin syndrome, QT prolongation, cardiac arrhythmias, severe hyponatremia, other adverse effects; may decr. tramadol active metabolite levels, efficacy (hepatic metab. inhibited, decr. conversion to active metabolite; additive effects)

• trazodone
Luvox (fluvoxamine)

+

trazodone

1 interaction

Avoid/Use Alternative

fluvoxamine + trazodone

use alternative or monitor sodium, bleeding s/sx, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of hyponatremia, serotonin syndrome, CNS depression, psychomotor impairment, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• trimethobenzamide
Luvox (fluvoxamine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

fluvoxamine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Luvox (fluvoxamine)

+

trimipramine

1 interaction

Avoid/Use Alternative

fluvoxamine + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. trimipramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• venetoclax
Luvox (fluvoxamine)

+

venetoclax

1 interaction

Avoid/Use Alternative

fluvoxamine + venetoclax

monitor CBC, tumor lysis syndrome s/sx; CLL/SLL: consider alternative or decr. venetoclax dose by at least 50%; AML: decr. venetoclax dose by at least 50%: combo may incr. venetoclax levels, risk of serious infection, myelosuppression, tumor lysis syndrome, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• venlafaxine
Luvox (fluvoxamine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

fluvoxamine + venlafaxine

avoid combo: combo may incr. risk of bleeding (incl. life-threatening), hyponatremia, serotonin syndrome, CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Luvox (fluvoxamine)

+

vilazodone

1 interaction

Avoid/Use Alternative

fluvoxamine + vilazodone

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, CNS depression, psychomotor impairment, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• vorasidenib
Luvox (fluvoxamine)

+

vorasidenib

1 interaction

Avoid/Use Alternative

fluvoxamine + vorasidenib

use alternative: combo may incr. vorasidenib levels, risk of adverse effects (hepatic metab. inhibited)

• vortioxetine
Luvox (fluvoxamine)

+

vortioxetine

1 interaction

Avoid/Use Alternative

fluvoxamine + vortioxetine

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• yohimbe
Luvox (fluvoxamine)

+

yohimbe

1 interaction

Avoid/Use Alternative

fluvoxamine + yohimbe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, yohimbe inhibits monoamine oxidase)

• ziprasidone
Luvox (fluvoxamine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

fluvoxamine + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• zolmitriptan
Luvox (fluvoxamine)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

fluvoxamine + zolmitriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. zolmitriptan levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

Monitor/Modify Tx

• abemaciclib
Luvox (fluvoxamine)

+

abemaciclib

1 interaction

Monitor/Modify Tx

fluvoxamine + abemaciclib

monitor CBC: combo may incr. abemaciclib levels, risk of serious infection, myelosuppression, thrombosis risk, other adverse effects (hepatic metab. inhibited)

• acalabrutinib
Luvox (fluvoxamine)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

fluvoxamine + acalabrutinib

monitor CBC, bleeding s/sx: combo may incr. acalabrutinib levels, risk of bleeding (incl. life-threatening), serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ado-trastuzumab emtansine
Luvox (fluvoxamine)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

fluvoxamine + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• afatinib
Luvox (fluvoxamine)

+

afatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + afatinib

monitor bleeding s/sx; decr. afatinib dose by 10 mg/day if not tolerated: combo may incr. afatinib levels, risk of GI or other bleeding (incl. life-threatening), other adverse effects (P-gp-mediated transport inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• alteplase
Luvox (fluvoxamine)

+

alteplase

1 interaction

Monitor/Modify Tx

fluvoxamine + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• amiloride
Luvox (fluvoxamine)

+

amiloride

1 interaction

Monitor/Modify Tx

fluvoxamine + amiloride

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• aminophylline
Luvox (fluvoxamine)

+

aminophylline

1 interaction

Monitor/Modify Tx

fluvoxamine + aminophylline

monitor theophylline levels; decr. theophylline to 1/3 usual dose: combo may incr. theophylline levels, risk of cardiac arrhythmias, seizures, other toxicities (hepatic metab. inhibited; aminophylline converted to theophylline)

• amiodarone
Luvox (fluvoxamine)

+

amiodarone

1 interaction

Monitor/Modify Tx

fluvoxamine + amiodarone

monitor ECG: combo may incr. amiodarone levels, risk of QT prolongation, cardiac arrhythmias, bradycardia, other adverse effects (hepatic metab. inhibited)

• anacaulase topical
Luvox (fluvoxamine)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

fluvoxamine + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• anagrelide
Luvox (fluvoxamine)

+

anagrelide

1 interaction

Monitor/Modify Tx

fluvoxamine + anagrelide

monitor ECG, bleeding s/sx; consider decr. anagrelide dose: combo may incr. anagrelide levels, risk of QT prolongation, cardiac arrhythmias, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• antithrombin
Luvox (fluvoxamine)

+

antithrombin

1 interaction

Monitor/Modify Tx

fluvoxamine + antithrombin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• argatroban
Luvox (fluvoxamine)

+

argatroban

1 interaction

Monitor/Modify Tx

fluvoxamine + argatroban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• aripiprazole lauroxil
Luvox (fluvoxamine)

+

aripiprazole lauroxil

1 interaction

Monitor/Modify Tx

fluvoxamine + aripiprazole lauroxil

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (additive effects)

• asenapine
Luvox (fluvoxamine)

+

asenapine

1 interaction

Monitor/Modify Tx

fluvoxamine + asenapine

consider decr. asenapine dose: combo may incr. asenapine levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• asparaginase
Luvox (fluvoxamine)

+

asparaginase

1 interaction

Monitor/Modify Tx

fluvoxamine + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• aspirin
Luvox (fluvoxamine)

+

aspirin

1 interaction

Monitor/Modify Tx

fluvoxamine + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• atorvastatin
Luvox (fluvoxamine)

+

atorvastatin

1 interaction

Monitor/Modify Tx

fluvoxamine + atorvastatin

monitor CK, myopathy sx: combo may incr. atorvastatin levels, risk of myopathy, rhabdomyolysis, other adverse effects (P-gp-mediated transport inhibited)

• avanafil
Luvox (fluvoxamine)

+

avanafil

1 interaction

Monitor/Modify Tx

fluvoxamine + avanafil

monitor BP; consider decr. avanafil dose: combo may incr. avanafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• avapritinib
Luvox (fluvoxamine)

+

avapritinib

1 interaction

Monitor/Modify Tx

fluvoxamine + avapritinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• axitinib
Luvox (fluvoxamine)

+

axitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• baclofen intrathecal
Luvox (fluvoxamine)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

fluvoxamine + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• belzutifan
Luvox (fluvoxamine)

+

belzutifan

1 interaction

Monitor/Modify Tx

fluvoxamine + belzutifan

monitor Hgb, hypoxia s/sx: combo may incr. belzutifan levels, risk of anemia, hypoxia, other adverse effects (hepatic metab. inhibited)

• bevacizumab
Luvox (fluvoxamine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

fluvoxamine + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• binimetinib
Luvox (fluvoxamine)

+

binimetinib

1 interaction

Monitor/Modify Tx

fluvoxamine + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bivalirudin
Luvox (fluvoxamine)

+

bivalirudin

1 interaction

Monitor/Modify Tx

fluvoxamine + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• brentuximab vedotin
Luvox (fluvoxamine)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

fluvoxamine + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• brigatinib
Luvox (fluvoxamine)

+

brigatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + brigatinib

monitor BP, HR: combo may incr. brigatinib levels, risk of HTN, bradycardia, other adverse effects (hepatic metab. inhibited)

• brivaracetam
Luvox (fluvoxamine)

+

brivaracetam

1 interaction

Monitor/Modify Tx

fluvoxamine + brivaracetam

consider decr. brivaracetam dose: combo may incr. brivaracetam levels, risk of CNS depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• bromelain
Luvox (fluvoxamine)

+

bromelain

1 interaction

Monitor/Modify Tx

fluvoxamine + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bromfenac ophthalmic
Luvox (fluvoxamine)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

fluvoxamine + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bumetanide
Luvox (fluvoxamine)

+

bumetanide

1 interaction

Monitor/Modify Tx

fluvoxamine + bumetanide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• bupropion
Luvox (fluvoxamine)

+

bupropion

1 interaction

Monitor/Modify Tx

fluvoxamine + bupropion

consider lower bupropion doses: combo may incr. fluvoxamine levels, risk of seizures, other adverse effects (hepatic metab. inhibited, additive effects)

• cabazitaxel
Luvox (fluvoxamine)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

fluvoxamine + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cabozantinib
Luvox (fluvoxamine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

fluvoxamine + cabozantinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• caffeine citrate
Luvox (fluvoxamine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

fluvoxamine + caffeine citrate

monitor caffeine levels: combo may incr. caffeine levels, risk of cardiovascular and CNS stimulatory effects, toxicity (hepatic metab. inhibited)

• calaspargase
Luvox (fluvoxamine)

+

calaspargase

1 interaction

Monitor/Modify Tx

fluvoxamine + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cangrelor
Luvox (fluvoxamine)

+

cangrelor

1 interaction

Monitor/Modify Tx

fluvoxamine + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• capivasertib
Luvox (fluvoxamine)

+

capivasertib

1 interaction

Monitor/Modify Tx

fluvoxamine + capivasertib

monitor glucose: combo may incr. capivasertib levels, risk of severe hyperglycemia, other adverse effects (hepatic metab. inhibited)

• caplacizumab
Luvox (fluvoxamine)

+

caplacizumab

1 interaction

Monitor/Modify Tx

fluvoxamine + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• carfilzomib
Luvox (fluvoxamine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

fluvoxamine + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• celecoxib
Luvox (fluvoxamine)

+

celecoxib

1 interaction

Monitor/Modify Tx

fluvoxamine + celecoxib

monitor bleeding s/sx: combo may incr. celecoxib levels, risk of GI or other bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• chlordiazepoxide
Luvox (fluvoxamine)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

fluvoxamine + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorothiazide
Luvox (fluvoxamine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

fluvoxamine + chlorothiazide

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• chlorpromazine
Luvox (fluvoxamine)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

fluvoxamine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. chlorpromazine levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• chlorthalidone
Luvox (fluvoxamine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

fluvoxamine + chlorthalidone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• cilostazol
Luvox (fluvoxamine)

+

cilostazol

1 interaction

Monitor/Modify Tx

fluvoxamine + cilostazol

monitor bleeding s/sx; decr. cilostazol dose to 50 mg bid: combo may incr. cilostazol levels, risk of bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cisplatin
Luvox (fluvoxamine)

+

cisplatin

1 interaction

Monitor/Modify Tx

fluvoxamine + cisplatin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• clobazam
Luvox (fluvoxamine)

+

clobazam

1 interaction

Monitor/Modify Tx

fluvoxamine + clobazam

monitor resp. rate; consider decr. clobazam dose: combo may incr. clobazam and active metabolite levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• clonazepam
Luvox (fluvoxamine)

+

clonazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• clorazepate
Luvox (fluvoxamine)

+

clorazepate

1 interaction

Monitor/Modify Tx

fluvoxamine + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• clozapine
Luvox (fluvoxamine)

+

clozapine

1 interaction

Monitor/Modify Tx

fluvoxamine + clozapine

monitor ECG, BP, HR; decr. clozapine to 1/3 usual dose: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, CNS depression, psychomotor impairment, seizures, other adverse effects (hepatic metab. inhibited, additive effects)

• collagenase clostridium histolyticum
Luvox (fluvoxamine)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

fluvoxamine + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, incl. severe (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cyclophosphamide
Luvox (fluvoxamine)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

fluvoxamine + cyclophosphamide

monitor sodium: combo may decr. cyclophosphamide active metabolite levels, efficacy; may incr. risk of hyponatremia, incl. life-threatening (hepatic metab. possibly induced, incr. active metabolite formation; additive effects)

• cyclosporine
Luvox (fluvoxamine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

fluvoxamine + cyclosporine

monitor cyclosporine levels, renal fxn: combo may incr. cyclosporine levels, risk of serious infection, nephrotoxicity, other adverse effects (P-gp-mediated transport inhibited)

• cysteamine
Luvox (fluvoxamine)

+

cysteamine

1 interaction

Monitor/Modify Tx

fluvoxamine + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dalteparin
Luvox (fluvoxamine)

+

dalteparin

1 interaction

Monitor/Modify Tx

fluvoxamine + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• danshen
Luvox (fluvoxamine)

+

danshen

1 interaction

Monitor/Modify Tx

fluvoxamine + danshen

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• daridorexant
Luvox (fluvoxamine)

+

daridorexant

1 interaction

Monitor/Modify Tx

fluvoxamine + daridorexant

consider decr. dose of one or both drugs: combo may incr. daridorexant levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• dasatinib
Luvox (fluvoxamine)

+

dasatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + dasatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• deferasirox
Luvox (fluvoxamine)

+

deferasirox

1 interaction

Monitor/Modify Tx

fluvoxamine + deferasirox

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• defibrotide
Luvox (fluvoxamine)

+

defibrotide

1 interaction

Monitor/Modify Tx

fluvoxamine + defibrotide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• desflurane
Luvox (fluvoxamine)

+

desflurane

1 interaction

Monitor/Modify Tx

fluvoxamine + desflurane

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desmopressin
Luvox (fluvoxamine)

+

desmopressin

1 interaction

Monitor/Modify Tx

fluvoxamine + desmopressin

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• deuruxolitinib
Luvox (fluvoxamine)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + deuruxolitinib

monitor CBC, bleeding or thrombosis s/sx: combo may incr. deuruxolitinib levels, risk of serious infection, thromboembolism, myelosuppression, GI or other bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dexmedetomidine
Luvox (fluvoxamine)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

fluvoxamine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Luvox (fluvoxamine)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

fluvoxamine + dexmedetomidine injection

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• diazoxide
Luvox (fluvoxamine)

+

diazoxide

1 interaction

Monitor/Modify Tx

fluvoxamine + diazoxide

HYPERPHAGIA USE: monitor glucose; see diazoxide choline pkg insert for wt-based dose adjustments; HYPOGLYCEMIA USE: monitor glucose: combo may incr. diazoxide levels, risk of hyperglycemia, other adverse effects (hepatic metab. inhibited)

• diclofenac
Luvox (fluvoxamine)

+

diclofenac

1 interaction

Monitor/Modify Tx

fluvoxamine + diclofenac

monitor bleeding s/sx; use lowest effective diclofenac dose, shortest duration of concomitant tx: combo may incr. diclofenac levels, risk of GI or other bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac ophthalmic
Luvox (fluvoxamine)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

fluvoxamine + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac topical
Luvox (fluvoxamine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

fluvoxamine + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diflunisal
Luvox (fluvoxamine)

+

diflunisal

1 interaction

Monitor/Modify Tx

fluvoxamine + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diltiazem
Luvox (fluvoxamine)

+

diltiazem

1 interaction

Monitor/Modify Tx

fluvoxamine + diltiazem

monitor BP, HR: combo may incr. risk of bradycardia (mechanism unknown)

• dimethyl fumarate
Luvox (fluvoxamine)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

fluvoxamine + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dinutuximab
Luvox (fluvoxamine)

+

dinutuximab

1 interaction

Monitor/Modify Tx

fluvoxamine + dinutuximab

monitor sodium: combo may incr. risk of severe hyponatremia (additive effects)

• diosmin
Luvox (fluvoxamine)

+

diosmin

1 interaction

Monitor/Modify Tx

fluvoxamine + diosmin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dipyridamole
Luvox (fluvoxamine)

+

dipyridamole

1 interaction

Monitor/Modify Tx

fluvoxamine + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diroximel fumarate
Luvox (fluvoxamine)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

fluvoxamine + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• disopyramide
Luvox (fluvoxamine)

+

disopyramide

1 interaction

Monitor/Modify Tx

fluvoxamine + disopyramide

monitor disopyramide levels, ECG: combo may incr. disopyramide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• docetaxel
Luvox (fluvoxamine)

+

docetaxel

1 interaction

Monitor/Modify Tx

fluvoxamine + docetaxel

monitor CBC: combo may incr. docetaxel levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• dofetilide
Luvox (fluvoxamine)

+

dofetilide

1 interaction

Monitor/Modify Tx

fluvoxamine + dofetilide

monitor ECG: combo may incr. dofetilide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• domperidone
Luvox (fluvoxamine)

+

domperidone

1 interaction

Monitor/Modify Tx

fluvoxamine + domperidone

monitor ECG, HR, electrolytes: combo may incr. domperidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• droperidol
Luvox (fluvoxamine)

+

droperidol

1 interaction

Monitor/Modify Tx

fluvoxamine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• encorafenib
Luvox (fluvoxamine)

+

encorafenib

1 interaction

Monitor/Modify Tx

fluvoxamine + encorafenib

monitor ECG, bleeding s/sx: combo may incr. encorafenib levels, risk of QT prolongation, cardiac arrhythmias, GI or other bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• enfortumab vedotin
Luvox (fluvoxamine)

+

enfortumab vedotin

1 interaction

Monitor/Modify Tx

fluvoxamine + enfortumab vedotin

if also combined w/ strong CYP3A4 inhibitor, monitor CBC, glucose: combo may incr. enfortumab vedotin levels, risk of myelosuppression, neuropathy, hyperglycemia, other adverse effects (P-gp-mediated transport inhibited)

• entrectinib
Luvox (fluvoxamine)

+

entrectinib

1 interaction

Monitor/Modify Tx

fluvoxamine + entrectinib

monitor ECG, CBC: combo may incr. entrectinib levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, myelosuppression, other adverse effects (hepatic metab. inhibited, additive effects)

• epoprostenol
Luvox (fluvoxamine)

+

epoprostenol

1 interaction

Monitor/Modify Tx

fluvoxamine + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eptifibatide
Luvox (fluvoxamine)

+

eptifibatide

1 interaction

Monitor/Modify Tx

fluvoxamine + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• erythromycin
Luvox (fluvoxamine)

+

erythromycin

1 interaction

Monitor/Modify Tx

fluvoxamine + erythromycin

monitor ECG: combo may incr. erythromycin levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• esketamine
Luvox (fluvoxamine)

+

esketamine

1 interaction

Monitor/Modify Tx

fluvoxamine + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Luvox (fluvoxamine)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

fluvoxamine + eslicarbazepine acetate

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• esomeprazole
Luvox (fluvoxamine)

+

esomeprazole

1 interaction

Monitor/Modify Tx

fluvoxamine + esomeprazole

consider decr. esomeprazole dose if dose >40 mg, especially if also combined w/ a CYP3A4 inhibitor: combo may incr. esomeprazole levels, risk of adverse effects (hepatic metab. inhibited)

• estazolam
Luvox (fluvoxamine)

+

estazolam

1 interaction

Monitor/Modify Tx

fluvoxamine + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Luvox (fluvoxamine)

+

eszopiclone

1 interaction

Monitor/Modify Tx

fluvoxamine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Luvox (fluvoxamine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

fluvoxamine + ethacrynic acid

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• ethanol (in some formulations)
Luvox (fluvoxamine)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

fluvoxamine + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etodolac
Luvox (fluvoxamine)

+

etodolac

1 interaction

Monitor/Modify Tx

fluvoxamine + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• etomidate
Luvox (fluvoxamine)

+

etomidate

1 interaction

Monitor/Modify Tx

fluvoxamine + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• evening primrose oil
Luvox (fluvoxamine)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

fluvoxamine + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• everolimus
Luvox (fluvoxamine)

+

everolimus

1 interaction

Monitor/Modify Tx

fluvoxamine + everolimus

TSC-ASSOC. SEGA, TSC-ASSOC. PARTIAL ONSET SEIZURES, TRANSPLANT: monitor everolimus levels, CBC; OTHER INDICATIONS: monitor CBC: combo may incr. everolimus levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• fedratinib
Luvox (fluvoxamine)

+

fedratinib

1 interaction

Monitor/Modify Tx

fluvoxamine + fedratinib

monitor CBC, LFTs: combo may incr. fedratinib levels, risk of myelosuppression, hepatotoxicity, other adverse effects (hepatic metab. inhibited)

• felodipine
Luvox (fluvoxamine)

+

felodipine

1 interaction

Monitor/Modify Tx

fluvoxamine + felodipine

monitor BP, HR: combo may incr. felodipine levels, risk of hypotension, reflex tachycardia, other adverse effects (hepatic metab. inhibited)

• fenoprofen
Luvox (fluvoxamine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

fluvoxamine + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenugreek
Luvox (fluvoxamine)

+

fenugreek

1 interaction

Monitor/Modify Tx

fluvoxamine + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• finerenone
Luvox (fluvoxamine)

+

finerenone

1 interaction

Monitor/Modify Tx

fluvoxamine + finerenone

monitor potassium: combo may incr. finerenone levels, risk of hyperkalemia, other adverse effects (hepatic metab. inhibited)

• flecainide
Luvox (fluvoxamine)

+

flecainide

1 interaction

Monitor/Modify Tx

fluvoxamine + flecainide

monitor flecainide levels, ECG: combo may incr. flecainide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• flibanserin
Luvox (fluvoxamine)

+

flibanserin

1 interaction

Monitor/Modify Tx

fluvoxamine + flibanserin

monitor BP: combo may incr. flibanserin levels, risk of CNS depression, psychomotor impairment, severe hypotension (incl. syncope), other adverse effects (hepatic metab. inhibited, additive effects)

• fluphenazine
Luvox (fluvoxamine)

+

fluphenazine

1 interaction

Monitor/Modify Tx

fluvoxamine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• flurazepam
Luvox (fluvoxamine)

+

flurazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• flurbiprofen
Luvox (fluvoxamine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

fluvoxamine + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen ophthalmic
Luvox (fluvoxamine)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

fluvoxamine + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fluvastatin
Luvox (fluvoxamine)

+

fluvastatin

1 interaction

Monitor/Modify Tx

fluvoxamine + fluvastatin

monitor CK, myopathy sx: combo may incr. fluvastatin levels, risk of myopathy, rhabdomyolysis, other adverse effects (hepatic metab. inhibited)

• fosphenytoin
Luvox (fluvoxamine)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

fluvoxamine + fosphenytoin

monitor phenytoin levels: combo may incr. phenytoin levels, risk of CNS depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• fruquintinib
Luvox (fluvoxamine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

fluvoxamine + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• furosemide
Luvox (fluvoxamine)

+

furosemide

1 interaction

Monitor/Modify Tx

fluvoxamine + furosemide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• gabapentin
Luvox (fluvoxamine)

+

gabapentin

1 interaction

Monitor/Modify Tx

fluvoxamine + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• gabapentin enacarbil
Luvox (fluvoxamine)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

fluvoxamine + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• garlic
Luvox (fluvoxamine)

+

garlic

1 interaction

Monitor/Modify Tx

fluvoxamine + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gefitinib
Luvox (fluvoxamine)

+

gefitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gemtuzumab ozogamicin
Luvox (fluvoxamine)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

fluvoxamine + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ginkgo
Luvox (fluvoxamine)

+

ginkgo

1 interaction

Monitor/Modify Tx

fluvoxamine + ginkgo

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• glimepiride
Luvox (fluvoxamine)

+

glimepiride

1 interaction

Monitor/Modify Tx

fluvoxamine + glimepiride

monitor glucose: combo may incr. glimepiride levels, risk of hypoglycemia, other adverse effects (hepatic metab. inhibited)

• heparin
Luvox (fluvoxamine)

+

heparin

1 interaction

Monitor/Modify Tx

fluvoxamine + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• hydrochlorothiazide
Luvox (fluvoxamine)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

fluvoxamine + hydrochlorothiazide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• hydrocortisone
Luvox (fluvoxamine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

fluvoxamine + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• hydroxyzine
Luvox (fluvoxamine)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

fluvoxamine + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ibrutinib
Luvox (fluvoxamine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

fluvoxamine + ibrutinib

monitor bleeding s/sx; consider decr. ibrutinib dose: combo may incr. ibrutinib levels, risk of bleeding (incl. life-threatening), serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen
Luvox (fluvoxamine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

fluvoxamine + ibuprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen lysine
Luvox (fluvoxamine)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

fluvoxamine + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• icosapent ethyl
Luvox (fluvoxamine)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

fluvoxamine + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ifosfamide
Luvox (fluvoxamine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

fluvoxamine + ifosfamide

monitor sodium; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia (additive effects)

• iloprost inhaled
Luvox (fluvoxamine)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

fluvoxamine + iloprost inhaled

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• imatinib
Luvox (fluvoxamine)

+

imatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + imatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• indapamide
Luvox (fluvoxamine)

+

indapamide

1 interaction

Monitor/Modify Tx

fluvoxamine + indapamide

monitor sodium: combo may incr. risk of severe hyponatremia (additive effects)

• indomethacin
Luvox (fluvoxamine)

+

indomethacin

1 interaction

Monitor/Modify Tx

fluvoxamine + indomethacin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• infigratinib
Luvox (fluvoxamine)

+

infigratinib

1 interaction

Monitor/Modify Tx

fluvoxamine + infigratinib

monitor phosphate: combo may incr. infigratinib levels, risk of hyperphosphatemia, other adverse effects (hepatic metab. inhibited)

• iopamidol
Luvox (fluvoxamine)

+

iopamidol

1 interaction

Monitor/Modify Tx

fluvoxamine + iopamidol

caution advised if intrathecal iopamidol use; consider holding fluvoxamine at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• isoflurane
Luvox (fluvoxamine)

+

isoflurane

1 interaction

Monitor/Modify Tx

fluvoxamine + isoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ivabradine
Luvox (fluvoxamine)

+

ivabradine

1 interaction

Monitor/Modify Tx

fluvoxamine + ivabradine

monitor HR, ECG: combo may incr. ivabradine levels, risk of bradycardia, QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ivosidenib
Luvox (fluvoxamine)

+

ivosidenib

1 interaction

Monitor/Modify Tx

fluvoxamine + ivosidenib

monitor ECG: combo may incr. ivosidenib levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ixabepilone
Luvox (fluvoxamine)

+

ixabepilone

1 interaction

Monitor/Modify Tx

fluvoxamine + ixabepilone

monitor CBC: combo may incr. ixabepilone levels, risk of serious infection, myelosuppression, other toxicity (hepatic metab. inhibited)

• ketamine
Luvox (fluvoxamine)

+

ketamine

1 interaction

Monitor/Modify Tx

fluvoxamine + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• ketoprofen
Luvox (fluvoxamine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

fluvoxamine + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac
Luvox (fluvoxamine)

+

ketorolac

1 interaction

Monitor/Modify Tx

fluvoxamine + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac ophthalmic
Luvox (fluvoxamine)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

fluvoxamine + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lemborexant
Luvox (fluvoxamine)

+

lemborexant

1 interaction

Monitor/Modify Tx

fluvoxamine + lemborexant

monitor resp. rate; adjust max lemborexant dose to 5 mg/day: combo may incr. lemborexant levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• lenvatinib
Luvox (fluvoxamine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• levoketoconazole
Luvox (fluvoxamine)

+

levoketoconazole

1 interaction

Monitor/Modify Tx

fluvoxamine + levoketoconazole

consider monitoring ECG: combo may incr. levoketoconazole levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• lidocaine
Luvox (fluvoxamine)

+

lidocaine

1 interaction

Monitor/Modify Tx

fluvoxamine + lidocaine

monitor lidocaine levels if lidocaine antiarrhythmic use; otherwise, monitor BP, HR: combo may incr. lidocaine levels, risk of hypotension, bradycardia, other adverse effects; risk may be higher w/ continuous infusion or higher doses for local anesthesia (hepatic metab. inhibited)

• lifileucel
Luvox (fluvoxamine)

+

lifileucel

1 interaction

Monitor/Modify Tx

fluvoxamine + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lomitapide
Luvox (fluvoxamine)

+

lomitapide

1 interaction

Monitor/Modify Tx

fluvoxamine + lomitapide

max lomitapide dose 30 mg/day: combo may incr. lomitapide levels, risk of adverse effects (hepatic metab. inhibited)

• lonafarnib
Luvox (fluvoxamine)

+

lonafarnib

1 interaction

Monitor/Modify Tx

fluvoxamine + lonafarnib

consider monitoring HR, ECG, electrolytes: combo may incr. lonafarnib levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• lorazepam
Luvox (fluvoxamine)

+

lorazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + lorazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• lovastatin
Luvox (fluvoxamine)

+

lovastatin

1 interaction

Monitor/Modify Tx

fluvoxamine + lovastatin

monitor CK, myopathy sx: combo may incr. lovastatin levels, risk of myopathy, rhabdomyolysis, other adverse effects (hepatic metab. inhibited)

• lumateperone
Luvox (fluvoxamine)

+

lumateperone

1 interaction

Monitor/Modify Tx

fluvoxamine + lumateperone

monitor ECG: combo may incr. lumateperone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• lurasidone
Luvox (fluvoxamine)

+

lurasidone

1 interaction

Monitor/Modify Tx

fluvoxamine + lurasidone

monitor ECG: combo may incr. lurasidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• lurbinectedin
Luvox (fluvoxamine)

+

lurbinectedin

1 interaction

Monitor/Modify Tx

fluvoxamine + lurbinectedin

monitor CBC: combo may incr. lurbinectedin levels, risk of myelosuppression, other adverse effects (hepatic metab. inhibited)

• magnesium citrate
Luvox (fluvoxamine)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

fluvoxamine + magnesium citrate

monitor sodium, especially if magnesium citrate bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• magnesium salicylate
Luvox (fluvoxamine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

fluvoxamine + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mannitol
Luvox (fluvoxamine)

+

mannitol

1 interaction

Monitor/Modify Tx

fluvoxamine + mannitol

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures (additive effects)

• mavorixafor
Luvox (fluvoxamine)

+

mavorixafor

1 interaction

Monitor/Modify Tx

fluvoxamine + mavorixafor

monitor ECG: combo may incr. levels of both drugs, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• meclofenamate
Luvox (fluvoxamine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

fluvoxamine + meclofenamate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mefenamic acid
Luvox (fluvoxamine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

fluvoxamine + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• meloxicam
Luvox (fluvoxamine)

+

meloxicam

1 interaction

Monitor/Modify Tx

fluvoxamine + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methohexital
Luvox (fluvoxamine)

+

methohexital

1 interaction

Monitor/Modify Tx

fluvoxamine + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methotrexate
Luvox (fluvoxamine)

+

methotrexate

1 interaction

Monitor/Modify Tx

fluvoxamine + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methyl salicylate topical
Luvox (fluvoxamine)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

fluvoxamine + methyl salicylate topical

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• metolazone
Luvox (fluvoxamine)

+

metolazone

1 interaction

Monitor/Modify Tx

fluvoxamine + metolazone

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• mexiletine
Luvox (fluvoxamine)

+

mexiletine

1 interaction

Monitor/Modify Tx

fluvoxamine + mexiletine

titrate slowly; consider monitoring mexiletine levels: combo may incr. mexiletine levels, risk of adverse effects (hepatic metab. inhibited)

• mitotane
Luvox (fluvoxamine)

+

mitotane

1 interaction

Monitor/Modify Tx

fluvoxamine + mitotane

monitor bleeding s/sx: combo may incr. risk of CNS depression, psychomotor impairment, bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mobocertinib
Luvox (fluvoxamine)

+

mobocertinib

1 interaction

Monitor/Modify Tx

fluvoxamine + mobocertinib

monitor ECG: combo may incr. mobocertinib levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• monomethyl fumarate
Luvox (fluvoxamine)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

fluvoxamine + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mycophenolate mofetil
Luvox (fluvoxamine)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

fluvoxamine + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of CNS depression, psychomotor impairment, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mycophenolic acid
Luvox (fluvoxamine)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

fluvoxamine + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nabumetone
Luvox (fluvoxamine)

+

nabumetone

1 interaction

Monitor/Modify Tx

fluvoxamine + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• naproxen
Luvox (fluvoxamine)

+

naproxen

1 interaction

Monitor/Modify Tx

fluvoxamine + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nattokinase
Luvox (fluvoxamine)

+

nattokinase

1 interaction

Monitor/Modify Tx

fluvoxamine + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nelarabine
Luvox (fluvoxamine)

+

nelarabine

1 interaction

Monitor/Modify Tx

fluvoxamine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nepafenac ophthalmic
Luvox (fluvoxamine)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

fluvoxamine + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• niacin (vitamin B3)
Luvox (fluvoxamine)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

fluvoxamine + niacin (vitamin B3)

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nifedipine
Luvox (fluvoxamine)

+

nifedipine

1 interaction

Monitor/Modify Tx

fluvoxamine + nifedipine

monitor BP, consider lowest nifedipine start dose: combo may incr. nifedipine levels, risk of hypotension, other adverse effects (hepatic metab. inhibited)

• nilotinib
Luvox (fluvoxamine)

+

nilotinib

1 interaction

Monitor/Modify Tx

fluvoxamine + nilotinib

monitor sodium, bleeding s/sx: combo may incr. risk of hyponatremia, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nimodipine
Luvox (fluvoxamine)

+

nimodipine

1 interaction

Monitor/Modify Tx

fluvoxamine + nimodipine

monitor BP: combo may incr. nimodipine levels, risk of hypotension, other adverse effects (hepatic metab. inhibited)

• nintedanib
Luvox (fluvoxamine)

+

nintedanib

1 interaction

Monitor/Modify Tx

fluvoxamine + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nisoldipine
Luvox (fluvoxamine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

fluvoxamine + nisoldipine

monitor BP: combo may incr. nisoldipine levels, risk of hypotension, other adverse effects (hepatic metab. inhibited)

• nusinersen
Luvox (fluvoxamine)

+

nusinersen

1 interaction

Monitor/Modify Tx

fluvoxamine + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• olanzapine
Luvox (fluvoxamine)

+

olanzapine

1 interaction

Monitor/Modify Tx

fluvoxamine + olanzapine

monitor BP; consider decr. olanzapine dose: combo may incr. olanzapine levels, risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis), other adverse effects (hepatic metab. inhibited, additive effects)

• omega-3-acid
Luvox (fluvoxamine)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

fluvoxamine + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• omeprazole
Luvox (fluvoxamine)

+

omeprazole

1 interaction

Monitor/Modify Tx

fluvoxamine + omeprazole

consider decr. omeprazole dose if dose >40 mg, especially if also combined w/ a CYP3A4 inhibitor: combo may incr. omeprazole levels, risk of adverse effects (hepatic metab. inhibited)

• opicapone
Luvox (fluvoxamine)

+

opicapone

1 interaction

Monitor/Modify Tx

fluvoxamine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxaliplatin
Luvox (fluvoxamine)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

fluvoxamine + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxaprozin
Luvox (fluvoxamine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

fluvoxamine + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxazepam
Luvox (fluvoxamine)

+

oxazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxcarbazepine
Luvox (fluvoxamine)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

fluvoxamine + oxcarbazepine

monitor sodium: combo may incr. risk of hyponatremia, seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• oxybutynin
Luvox (fluvoxamine)

+

oxybutynin

1 interaction

Monitor/Modify Tx

fluvoxamine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxytocin
Luvox (fluvoxamine)

+

oxytocin

1 interaction

Monitor/Modify Tx

fluvoxamine + oxytocin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• paclitaxel
Luvox (fluvoxamine)

+

paclitaxel

1 interaction

Monitor/Modify Tx

fluvoxamine + paclitaxel

monitor CBC: combo may incr. paclitaxel levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• pacritinib
Luvox (fluvoxamine)

+

pacritinib

1 interaction

Monitor/Modify Tx

fluvoxamine + pacritinib

monitor ECG, CBC, bleeding s/sx: combo may incr. pacritinib levels, risk of QT prolongation, cardiac arrhythmias, myelosuppression, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
Luvox (fluvoxamine)

+

pazopanib

1 interaction

Monitor/Modify Tx

fluvoxamine + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pegaspargase
Luvox (fluvoxamine)

+

pegaspargase

1 interaction

Monitor/Modify Tx

fluvoxamine + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pemigatinib
Luvox (fluvoxamine)

+

pemigatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + pemigatinib

monitor phosphate: combo may incr. pemigatinib levels, risk of hyperphosphatemia, other adverse effects (hepatic metab. inhibited)

• penicillin G
Luvox (fluvoxamine)

+

penicillin G

1 interaction

Monitor/Modify Tx

fluvoxamine + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentobarbital
Luvox (fluvoxamine)

+

pentobarbital

1 interaction

Monitor/Modify Tx

fluvoxamine + pentobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pentosan polysulfate sodium
Luvox (fluvoxamine)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

fluvoxamine + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentoxifylline
Luvox (fluvoxamine)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

fluvoxamine + pentoxifylline

monitor bleeding s/sx: combo may incr. pentoxifylline levels, risk of bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• perphenazine
Luvox (fluvoxamine)

+

perphenazine

1 interaction

Monitor/Modify Tx

fluvoxamine + perphenazine

consider decr. dose of one or both drugs: combo may incr. perphenazine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• phenobarbital
Luvox (fluvoxamine)

+

phenobarbital

1 interaction

Monitor/Modify Tx

fluvoxamine + phenobarbital

monitor phenobarbital levels, resp. rate: combo may incr. phenobarbital levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. possibly inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• phenytoin
Luvox (fluvoxamine)

+

phenytoin

1 interaction

Monitor/Modify Tx

fluvoxamine + phenytoin

monitor phenytoin levels: combo may incr. phenytoin levels, risk of CNS depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• piperacillin
Luvox (fluvoxamine)

+

piperacillin

1 interaction

Monitor/Modify Tx

fluvoxamine + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• piroxicam
Luvox (fluvoxamine)

+

piroxicam

1 interaction

Monitor/Modify Tx

fluvoxamine + piroxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pirtobrutinib
Luvox (fluvoxamine)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

fluvoxamine + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• plasminogen, human
Luvox (fluvoxamine)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

fluvoxamine + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• polyethylene glycol
Luvox (fluvoxamine)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

fluvoxamine + polyethylene glycol

monitor sodium, especially if polyethylene glycol bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• polyethylene glycol/electrolytes
Luvox (fluvoxamine)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

fluvoxamine + polyethylene glycol/ electrolytes

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• ponatinib
Luvox (fluvoxamine)

+

ponatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• porfimer
Luvox (fluvoxamine)

+

porfimer

1 interaction

Monitor/Modify Tx

fluvoxamine + porfimer

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• prasugrel
Luvox (fluvoxamine)

+

prasugrel

1 interaction

Monitor/Modify Tx

fluvoxamine + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pregabalin
Luvox (fluvoxamine)

+

pregabalin

1 interaction

Monitor/Modify Tx

fluvoxamine + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• primidone
Luvox (fluvoxamine)

+

primidone

1 interaction

Monitor/Modify Tx

fluvoxamine + primidone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• propofol
Luvox (fluvoxamine)

+

propofol

1 interaction

Monitor/Modify Tx

fluvoxamine + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• propranolol
Luvox (fluvoxamine)

+

propranolol

1 interaction

Monitor/Modify Tx

fluvoxamine + propranolol

monitor BP, HR: combo may incr. propranolol levels, risk of hypotension, bradycardia, AV block, other adverse effects (hepatic metab. inhibited)

• quazepam
Luvox (fluvoxamine)

+

quazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quinidine (antiarrhythmic)
Luvox (fluvoxamine)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

fluvoxamine + quinidine (antiarrhythmic)

monitor quinidine levels, ECG: combo may incr. levels of both drugs, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• ramucirumab
Luvox (fluvoxamine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

fluvoxamine + ramucirumab

monitor sodium, bleeding s/sx: combo may incr. risk of hyponatremia, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ranibizumab
Luvox (fluvoxamine)

+

ranibizumab

1 interaction

Monitor/Modify Tx

fluvoxamine + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ranolazine
Luvox (fluvoxamine)

+

ranolazine

1 interaction

Monitor/Modify Tx

fluvoxamine + ranolazine

monitor ECG: combo may incr. ranolazine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (P-gp-mediated transport inhibited)

• red yeast rice
Luvox (fluvoxamine)

+

red yeast rice

1 interaction

Monitor/Modify Tx

fluvoxamine + red yeast rice

monitor CK, myopathy sx w/ large amounts of red yeast rice: combo may incr. lovastatin levels, risk of myopathy, rhabdomyolysis, other adverse effects (hepatic metab. inhibited, red yeast rice contains varying amounts of lovastatin)

• regorafenib
Luvox (fluvoxamine)

+

regorafenib

1 interaction

Monitor/Modify Tx

fluvoxamine + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• remimazolam
Luvox (fluvoxamine)

+

remimazolam

1 interaction

Monitor/Modify Tx

fluvoxamine + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• repaglinide
Luvox (fluvoxamine)

+

repaglinide

1 interaction

Monitor/Modify Tx

fluvoxamine + repaglinide

monitor glucose: combo may incr. repaglinide levels, risk of hypoglycemia, other adverse effects (hepatic metab. inhibited)

• resveratrol
Luvox (fluvoxamine)

+

resveratrol

1 interaction

Monitor/Modify Tx

fluvoxamine + resveratrol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• reteplase
Luvox (fluvoxamine)

+

reteplase

1 interaction

Monitor/Modify Tx

fluvoxamine + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ribociclib
Luvox (fluvoxamine)

+

ribociclib

1 interaction

Monitor/Modify Tx

fluvoxamine + ribociclib

monitor ECG, electrolytes, CBC: combo may incr. ribociclib levels, risk of QT prolongation, cardiac arrhythmias, myelosuppression, other adverse effects (hepatic metab. inhibited)

• romidepsin
Luvox (fluvoxamine)

+

romidepsin

1 interaction

Monitor/Modify Tx

fluvoxamine + romidepsin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• ropinirole
Luvox (fluvoxamine)

+

ropinirole

1 interaction

Monitor/Modify Tx

fluvoxamine + ropinirole

consider decr. ropinirole dose: combo may incr. ropinirole levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• safinamide
Luvox (fluvoxamine)

+

safinamide

1 interaction

Monitor/Modify Tx

fluvoxamine + safinamide

monitor serotonin syndrome sx, especially during initiation/titration, use lowest effective doses: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• salsalate
Luvox (fluvoxamine)

+

salsalate

1 interaction

Monitor/Modify Tx

fluvoxamine + salsalate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• saw palmetto
Luvox (fluvoxamine)

+

saw palmetto

1 interaction

Monitor/Modify Tx

fluvoxamine + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selinexor
Luvox (fluvoxamine)

+

selinexor

1 interaction

Monitor/Modify Tx

fluvoxamine + selinexor

monitor sodium: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia, incl. life-threatening (additive effects)

• selpercatinib
Luvox (fluvoxamine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

fluvoxamine + selpercatinib

monitor ECG, electrolytes, bleeding s/sx: combo may incr. selpercatinib levels, risk of QT prolongation, cardiac arrhythmias, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selumetinib
Luvox (fluvoxamine)

+

selumetinib

1 interaction

Monitor/Modify Tx

fluvoxamine + selumetinib

monitor LVEF, CK, myopathy sx, bleeding s/sx: combo may incr. selumetinib levels, risk of cardiotoxicity, myopathy, rhabdomyolysis, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet and anticoagulant effects augmented by SSRI inhibition of platelet serotonin uptake and vitamin E content in selumetinib capsules)

• sevoflurane
Luvox (fluvoxamine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

fluvoxamine + sevoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• sirolimus
Luvox (fluvoxamine)

+

sirolimus

1 interaction

Monitor/Modify Tx

fluvoxamine + sirolimus

monitor sirolimus levels: combo may incr. sirolimus levels, risk of serious infection, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• sorafenib
Luvox (fluvoxamine)

+

sorafenib

1 interaction

Monitor/Modify Tx

fluvoxamine + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sotatercept
Luvox (fluvoxamine)

+

sotatercept

1 interaction

Monitor/Modify Tx

fluvoxamine + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. severe or life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• spironolactone
Luvox (fluvoxamine)

+

spironolactone

1 interaction

Monitor/Modify Tx

fluvoxamine + spironolactone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• sulfate bowel prep
Luvox (fluvoxamine)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

fluvoxamine + sulfate bowel prep

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• sulindac
Luvox (fluvoxamine)

+

sulindac

1 interaction

Monitor/Modify Tx

fluvoxamine + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sunitinib
Luvox (fluvoxamine)

+

sunitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• suvorexant
Luvox (fluvoxamine)

+

suvorexant

1 interaction

Monitor/Modify Tx

fluvoxamine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Luvox (fluvoxamine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

fluvoxamine + tacrolimus

monitor tacrolimus levels, ECG, renal fxn: combo may incr. tacrolimus levels, risk of QT prolongation, cardiac arrhythmias, nephrotoxicity, other adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• tadalafil
Luvox (fluvoxamine)

+

tadalafil

1 interaction

Monitor/Modify Tx

fluvoxamine + tadalafil

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• temazepam
Luvox (fluvoxamine)

+

temazepam

1 interaction

Monitor/Modify Tx

fluvoxamine + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• temsirolimus
Luvox (fluvoxamine)

+

temsirolimus

1 interaction

Monitor/Modify Tx

fluvoxamine + temsirolimus

monitor CBC: combo may incr. temsirolimus and active metabolite sirolimus levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• tenecteplase
Luvox (fluvoxamine)

+

tenecteplase

1 interaction

Monitor/Modify Tx

fluvoxamine + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tenofovir alafenamide
Luvox (fluvoxamine)

+

tenofovir alafenamide

1 interaction

Monitor/Modify Tx

fluvoxamine + tenofovir alafenamide

if tenofovir alafenamide not admin. w/ cobicistat, monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (gut P-gp-mediated transport inhibited)

• tenofovir disoproxil
Luvox (fluvoxamine)

+

tenofovir disoproxil

1 interaction

Monitor/Modify Tx

fluvoxamine + tenofovir disoproxil

monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (gut P-gp-mediated transport inhibited)

• theophylline
Luvox (fluvoxamine)

+

theophylline

1 interaction

Monitor/Modify Tx

fluvoxamine + theophylline

monitor theophylline levels; decr. theophylline to 1/3 usual dose: combo may incr. theophylline levels, risk of cardiac arrhythmias, seizures, other toxicities (hepatic metab. inhibited)

• thiothixene
Luvox (fluvoxamine)

+

thiothixene

1 interaction

Monitor/Modify Tx

fluvoxamine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ticagrelor
Luvox (fluvoxamine)

+

ticagrelor

1 interaction

Monitor/Modify Tx

fluvoxamine + ticagrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tipranavir
Luvox (fluvoxamine)

+

tipranavir

1 interaction

Monitor/Modify Tx

fluvoxamine + tipranavir

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tirofiban
Luvox (fluvoxamine)

+

tirofiban

1 interaction

Monitor/Modify Tx

fluvoxamine + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tisotumab vedotin
Luvox (fluvoxamine)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

fluvoxamine + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tivozanib
Luvox (fluvoxamine)

+

tivozanib

1 interaction

Monitor/Modify Tx

fluvoxamine + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tofacitinib
Luvox (fluvoxamine)

+

tofacitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + tofacitinib

monitor CBC; if also combined w/ CYP3A4 inhibitor, adjust tofacitinib dose as follows: RHEUMATOID or PSORIATIC ARTHRITIS: decr. tofacitinib dose to 5 mg qd; ULCERATIVE COLITIS: decr. tofacitinib 22 mg qd dose to 11 mg qd; decr. tofacitinib 11 mg qd dose to 5 mg qd; decr. tofacitinib 10 mg bid dose to 5 mg bid; decr. tofacitinib 5 mg bid dose to 5 mg qd; JUVENILE IDIOPATHIC ARTHRITIS: decr. usual tofacitinib bid dose to qd: combo may incr. tofacitinib levels, risk of serious infection, myelosuppression, other adverse effects (hepatic metab. inhibited)

• tolmetin
Luvox (fluvoxamine)

+

tolmetin

1 interaction

Monitor/Modify Tx

fluvoxamine + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tolvaptan
Luvox (fluvoxamine)

+

tolvaptan

1 interaction

Monitor/Modify Tx

fluvoxamine + tolvaptan

consider decr. tolvaptan dose: combo may incr. tolvaptan levels, risk of adverse effects (hepatic metab. inhibited)

• torsemide
Luvox (fluvoxamine)

+

torsemide

1 interaction

Monitor/Modify Tx

fluvoxamine + torsemide

monitor renal fxn, BP, sodium: combo may incr. torsemide levels, risk of nephrotoxicity, hypotension, hyponatremia, other adverse effects (hepatic metab. inhibited, additive effects)

• tovorafenib
Luvox (fluvoxamine)

+

tovorafenib

1 interaction

Monitor/Modify Tx

fluvoxamine + tovorafenib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• trametinib
Luvox (fluvoxamine)

+

trametinib

1 interaction

Monitor/Modify Tx

fluvoxamine + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• treprostinil
Luvox (fluvoxamine)

+

treprostinil

1 interaction

Monitor/Modify Tx

fluvoxamine + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• triamterene
Luvox (fluvoxamine)

+

triamterene

1 interaction

Monitor/Modify Tx

fluvoxamine + triamterene

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• triazolam
Luvox (fluvoxamine)

+

triazolam

1 interaction

Monitor/Modify Tx

fluvoxamine + triazolam

monitor resp. rate: combo may incr. triazolam levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• triclabendazole
Luvox (fluvoxamine)

+

triclabendazole

1 interaction

Monitor/Modify Tx

fluvoxamine + triclabendazole

monitor ECG: combo may incr. triclabendazole levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ubrogepant
Luvox (fluvoxamine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

fluvoxamine + ubrogepant

limit ubrogepant dose to 50 mg, may give second 50 mg dose after 2h if needed: combo may incr. ubrogepant levels, risk of adverse effects (hepatic metab. inhibited, P-gp-mediated transport inhibited)

• upadacitinib
Luvox (fluvoxamine)

+

upadacitinib

1 interaction

Monitor/Modify Tx

fluvoxamine + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vadadustat
Luvox (fluvoxamine)

+

vadadustat

1 interaction

Monitor/Modify Tx

fluvoxamine + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• valproic acid
Luvox (fluvoxamine)

+

valproic acid

1 interaction

Monitor/Modify Tx

fluvoxamine + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding (incl. life-threatening), CNS depression, psychomotor impairment; may alter seizure control (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; antagonistic effects, fluvoxamine may decr. seizure threshold)

• vandetanib
Luvox (fluvoxamine)

+

vandetanib

1 interaction

Monitor/Modify Tx

fluvoxamine + vandetanib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vardenafil
Luvox (fluvoxamine)

+

vardenafil

1 interaction

Monitor/Modify Tx

fluvoxamine + vardenafil

monitor ECG: combo may incr. vardenafil levels, risk of QT prolongation, cardiac arrhythmias, hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• vasopressin
Luvox (fluvoxamine)

+

vasopressin

1 interaction

Monitor/Modify Tx

fluvoxamine + vasopressin

monitor BP, sodium: combo may incr. pressor response, risk of hyponatremia (additive effects)

• vinblastine
Luvox (fluvoxamine)

+

vinblastine

1 interaction

Monitor/Modify Tx

fluvoxamine + vinblastine

monitor CBC: combo may incr. vinblastine levels, risk of serious infection, myelosuppression, autonomic neuropathy, other adverse effects (hepatic metab. inhibited)

• vincristine
Luvox (fluvoxamine)

+

vincristine

1 interaction

Monitor/Modify Tx

fluvoxamine + vincristine

monitor CBC: combo may incr. vincristine levels, risk of serious infection, myelosuppression, autonomic neuropathy, other adverse effects (hepatic metab. inhibited)

• vinorelbine
Luvox (fluvoxamine)

+

vinorelbine

1 interaction

Monitor/Modify Tx

fluvoxamine + vinorelbine

monitor CBC: combo may incr. vinorelbine levels, risk of serious infection, myelosuppression, autonomic neuropathy, other adverse effects (hepatic metab. inhibited)

• vinpocetine
Luvox (fluvoxamine)

+

vinpocetine

1 interaction

Monitor/Modify Tx

fluvoxamine + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vorapaxar
Luvox (fluvoxamine)

+

vorapaxar

1 interaction

Monitor/Modify Tx

fluvoxamine + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• voriconazole
Luvox (fluvoxamine)

+

voriconazole

1 interaction

Monitor/Modify Tx

fluvoxamine + voriconazole

monitor ECG: combo may incr. voriconazole levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• warfarin
Luvox (fluvoxamine)

+

warfarin

1 interaction

Monitor/Modify Tx

fluvoxamine + warfarin

monitor INR, bleeding s/sx, especially during initiation/titration: combo may incr. warfarin levels, risk of bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, synergistic effects, anticoagulant effects augmented by inhibition of platelet serotonin uptake)

• willow bark
Luvox (fluvoxamine)

+

willow bark

1 interaction

Monitor/Modify Tx

fluvoxamine + willow bark

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; willow bark may contain salicylates)

• zaleplon
Luvox (fluvoxamine)

+

zaleplon

1 interaction

Monitor/Modify Tx

fluvoxamine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zanubrutinib
Luvox (fluvoxamine)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

fluvoxamine + zanubrutinib

monitor CBC, bleeding s/sx: combo may incr. zanubrutinib levels, risk of serious infection, myelosuppression, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ziconotide
Luvox (fluvoxamine)

+

ziconotide

1 interaction

Monitor/Modify Tx

fluvoxamine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Luvox (fluvoxamine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

fluvoxamine + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• zolpidem
Luvox (fluvoxamine)

+

zolpidem

1 interaction

Monitor/Modify Tx

fluvoxamine + zolpidem

consider decr. dose of one or both drugs: combo may incr. zolpidem levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)