Select a medication above to begin.
Victoza
liraglutide
Black Box Warnings .
Thyroid C-cell Tumor Risk
contraindicated in pts w/ medullary thyroid carcinoma (MTC) hx or family hx, or in pts w/ multiple endocrine neoplasia syndrome type 2 (MEN 2); dose-related and duration-dependent incr. in thyroid C-cell tumor incidence observed in rodents, but human relevance unknown; uncertain value of routine serum calcitonin or thyroid ultrasound monitoring; advise pts of potential MTC risk and thyroid tumor sx (e.g., neck mass, dysphagia, dyspnea, persistent hoarseness)
Adult Dosing .
Dosage forms: INJ (pen): 6 mg per mL
Special Note
- [prescribing info]
- Info: see other injectable liraglutide product for FDA-approved weight management dosing
diabetes mellitus, type 2
- [1.2-1.8 mg SC qd]
- Start: 0.6 mg SC qd x1wk, then 1.2 mg SC qd, then may incr. to 1.8 mg SC qd after at least 1wk; Max: 1.8 mg/day; Info: retitrate from 0.6 mg SC qd if tx interrupted for >3 days
cardiovascular event risk reduction - DM type 2 pts w/ estab. cardiovascular dz
- [1.2-1.8 mg SC qd]
- Start: 0.6 mg SC qd x1wk, then 1.2 mg SC qd, then may incr. to 1.8 mg SC qd after at least 1wk if additional glycemic control needed; Max: 1.8 mg/day; Info: retitrate from 0.6 mg SC qd if tx interrupted for >3 days
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: INJ (pen): 6 mg per mL
diabetes mellitus, type 2
- [10 yo and older]
- Dose: 0.6-1.8 mg SC qd; Start: 0.6 mg SC qd, may incr. by 0.6 mg/day no more frequently than qwk; Max: 1.8 mg/day; Info: retitrate from 0.6 mg SC qd if tx interrupted for >3 days
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- medullary thyroid CA hx
- medullary thyroid CA family hx
- multiple endocrine neoplasia syndrome type 2
- diabetes mellitus, type 1
- caution: hypersensitivity to GLP-1 agonists
- caution: renal impairment
- caution: nephrotoxic agent use, concurrent
- caution: volume depletion
- caution: GI dz, severe
- caution: gastroparesis
- caution: pancreatitis risk
- caution: pancreatitis hx
- caution: surgery
Drug Interactions .
Overview
liraglutide
GLP-1 agonist
- antidiabetic agent
- decreases gastrointestinal motility
- nephrotoxicity
- caution advised w/ concurrent oral drugs requiring rapid onset; liraglutide delays gastric emptying
Contraindicated
- cidofovir
- potassium chloride
- potassium citrate
Avoid/Use Alternative
- aldesleukin
- amikacin
- amikacin inhaled
- bumetanide
- clofarabine
- desogestrel (contraceptive)
- dienogest (contraceptive)
- drospirenone (contraceptive)
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethinyl estradiol (contraceptive)
- ethynodiol (contraceptive)
- foscarnet
- ganciclovir
- gentamicin
- levonorgestrel (contraceptive)
- levonorgestrel (post-coital contraceptive)
- mannitol
- methotrexate
- norethindrone (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- pentamidine
- polymyxin B
- streptomycin
- streptozocin
- tenofovir disoproxil
- tobramycin
- tobramycin inhaled
- ulipristal (post-coital contraceptive)
- valganciclovir
Monitor/Modify Tx
- acebutolol
- acyclovir
- adefovir dipivoxil
- alclometasone topical
- alectinib
- aliskiren
- aloe
- alogliptin
- alpelisib
- amcinonide topical
- amiloride
- amphotericin
- anthrax immune globulin
- aripiprazole
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- arsenic trioxide
- asenapine
- ashwagandha
- asparaginase
- aspirin
- atazanavir
- auranofin
- axitinib
- azilsartan medoxomil
- balsalazide
- benazepril
- berberine
- betamethasone
- betamethasone topical
- bevacizumab
- bismuth subsalicylate
- bleomycin
- bortezomib
- botulism immune globulin
- brentuximab vedotin
- brexpiprazole
- brigatinib
- bromocriptine
- budesonide
- cabozantinib
- calaspargase
- canagliflozin
- candesartan cilexetil
- capecitabine
- capivasertib
- captopril
- carboplatin
- carfilzomib
- cariprazine
- carvedilol
- cassia cinnamon
- celecoxib
- ceritinib
- chloroquine
- chlorothiazide
- chlorthalidone
- chromium
- ciprofloxacin
- cisplatin
- clarithromycin
- clindamycin
- clobetasol topical
- clocortolone topical
- clozapine
- colesevelam
- colistimethate
- copanlisib
- corticotropin
- cortisone
- creatine
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- dabrafenib
- danazol
- darunavir
- decitabine
- deferasirox
- deferoxamine
- deflazacort
- delafloxacin
- desonide topical
- desoximetasone topical
- dexamethasone
- diclofenac
- diclofenac topical
- diflorasone topical
- diflunisal
- digoxin
- disopyramide
- eleuthero
- enalapril
- enalaprilat
- enfortumab vedotin
- ephedra
- epinephrine
- ertugliflozin
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethanol
- ethinyl estradiol (hormone replacement)
- ethionamide
- etodolac
- etonogestrel (contraceptive)
- everolimus
- fenoprofen
- fenugreek
- flaxseed
- flucytosine
- fludrocortisone
- fluocinolone otic
- fluocinolone topical
- fluocinonide topical
- fluoxetine
- flurandrenolide topical
- flurbiprofen
- fluticasone propionate topical
- fosamprenavir
- fosinopril
- fosphenytoin
- furosemide
- garlic
- ginkgo
- ginseng, American
- ginseng, Asian
- glimepiride
- glipizide
- glyburide
- goserelin
- gymnema
- halcinonide topical
- halobetasol topical
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroxychloroquine
- ibuprofen
- ibuprofen lysine
- ifosfamide
- iloperidone
- immune globulin
- inavolisib
- indapamide
- indomethacin
- insulin
- iohexol
- irbesartan
- isocarboxazid
- isoniazid
- ketoprofen
- ketorolac
- lanreotide
- lenvatinib
- leuprolide
- levofloxacin
- levothyroxine
- lifileucel
- linagliptin
- linezolid
- liothyronine
- lisinopril
- lithium
- lopinavir/ritonavir
- lorlatinib
- losartan
- lumateperone
- lurasidone
- lurbinectedin
- lutetium Lu 177 dotatate
- lutetium Lu 177 vipivotide tetraxetan
- magnesium citrate
- magnesium salicylate
- mecasermin
- meclofenamate
- medroxyprogesterone (contraceptive)
- mefenamic acid
- megestrol
- meloxicam
- mesalamine
- mesalamine rectal
- methylprednisolone
- methyltestosterone
- metolazone
- metreleptin
- milk thistle
- mitomycin
- moexipril
- mometasone topical
- moxifloxacin
- nabumetone
- nadolol
- naproxen
- nateglinide
- nelfinavir
- neomycin
- niacin (vitamin B3)
- norelgestromin (contraceptive)
- norepinephrine
- nusinersen
- octreotide
- ofloxacin
- olanzapine
- olmesartan medoxomil
- olsalazine
- omacetaxine mepesuccinate
- oxaliplatin
- oxaprozin
- paliperidone
- pamidronate
- paromomycin
- pasireotide
- pazopanib
- pegaspargase
- peginterferon alfa 2a
- pegvisomant
- pemetrexed
- penicillamine
- pentostatin
- perindopril
- phenelzine
- phenylephrine
- phenytoin
- pindolol
- pioglitazone
- piroxicam
- plazomicin
- polyethylene glycol
- polyethylene glycol/electrolytes
- pramlintide
- prednicarbate topical
- prednisolone
- prednisone
- pseudoephedrine
- quetiapine
- quinapril
- quinine
- ramipril
- ramucirumab
- repaglinide
- Rho(D) immune globulin
- ribose
- risperidone
- ritonavir
- rituximab
- ropeginterferon alfa-2b
- rosiglitazone
- sacrosidase
- salsalate
- saxagliptin
- segesterone (contraceptive)
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- somapacitan
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- sparsentan
- spironolactone
- sucralfate
- sulfate bowel prep
- sulindac
- sunitinib
- tacrolimus
- telavancin
- telmisartan
- temsirolimus
- tenofovir alafenamide
- teprotumumab
- tesamorelin
- testosterone
- thyroid
- timolol
- tiopronin
- tipranavir
- tivozanib
- tolmetin
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- turmeric
- vaccinia immune globulin
- valacyclovir
- valsartan
- vamorolone
- vancomycin
- voclosporin
- vorinostat
- ziprasidone
- ziv-aflibercept
- zoledronic acid
- zonisamide
Caution Advised
- acetaminophen
- amoxicillin
- ampicillin
- azithromycin
- barium
- bedaquiline
- cefaclor
- cefadroxil
- cefdinir
- cefixime
- cefpodoxime
- cefprozil
- cefuroxime axetil
- cephalexin
- dapsone
- demeclocycline
- dicloxacillin
- doxazosin
- doxycycline
- erythromycin
- fosfomycin
- lefamulin
- metoclopramide
- metronidazole
- mexiletine
- minocycline
- omadacycline
- penicillin V
- potassium acid phosphate
- potassium gluconate
- potassium phosphate
- rifabutin
- rifampin
- rifapentine
- sarecycline
- secnidazole
- sulfadiazine
- sulfamethoxazole
- sulfasalazine
- tedizolid phosphate
- tetracycline
- tinidazole
- trimethoprim
Adverse Reactions .
Serious Reactions
- thyroid C-cell tumor (animal studies)
- medullary thyroid CA risk
- papillary thyroid CA
- hypersensitivity rxn
- anaphylaxis
- angioedema
- acute renal failure
- chronic renal failure exacerbation
- pancreatitis
- cholelithiasis
- cholecystitis
- ileus
- perioperative aspiration
Common Reactions
- hypoglycemia (peds pts)
- nausea
- diarrhea
- headache
- nasopharyngitis
- vomiting
- appetite decr.
- dyspepsia
- URI
- constipation
- back pain
- bilirubin incr.
- injection site rxn
- amylase incr.
- lipase incr.
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; risk of teratogenicity and decr. fetal wt based on animal data at <1x MRHD; possible risk of fetal death based on animal data at 11x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: unknown
Excretion: urine 6%, feces 5%; Half-life: 13h
Subclass: Diabetes: GLP-1 Agonists ; GLP-1 Agonists, Cardiovascular
Mechanism of Action
activates glucagon-like-peptide-1 (GLP-1) receptor, increasing insulin secretion, decreasing glucagon secretion, and delaying gastric emptying (incretin mimetic)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Novo Nordisk A/S
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/victoza
subcutaneous solution:
- 18 mg/3 mL (1 carton, 2 pens): $701.00
subcutaneous solution:
- 18 mg/3 mL (1 carton, 3 pens): $1,046.00
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.