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Nurtec ODT
rimegepant
Adult Dosing .
Dosage forms: ODT: 75 mg
migraine, acute
- [75 mg PO/SL x1]
- Max: 75 mg/24h
migraine prophylaxis, episodic
- [75 mg PO/SL qod]
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hepatic impairment, Child-Pugh Class C
Drug Interactions .
Overview
rimegepant
CGRP antagonist
- CYP3A4 substrate
- P-gp substrate
Avoid/Use Alternative
- adagrasib
- apalutamide
- atazanavir
- bosentan
- butalbital
- carbamazepine
- cenobamate
- ceritinib
- chloramphenicol
- clarithromycin
- cobicistat
- dabrafenib
- efavirenz
- encorafenib
- enzalutamide
- etravirine
- fexinidazole
- fosphenytoin
- idelalisib
- itraconazole
- ivosidenib
- ketoconazole
- levoketoconazole
- lonafarnib
- lopinavir/ritonavir
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- mifepristone
- mitapivat
- mitotane
- modafinil
- nafcillin
- nefazodone
- nelfinavir
- netupitant
- pacritinib
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- posaconazole
- primidone
- repotrectinib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- ritonavir
- sotorasib
- St. John's wort
- tipranavir
- tucatinib
- voriconazole
Monitor/Modify Tx
- amiodarone
- aprepitant
- avacopan
- azithromycin
- belumosudil
- berotralstat
- bisoprolol
- cannabidiol
- carvedilol
- ciprofloxacin
- clofazimine
- conivaptan
- crizotinib
- cyclosporine
- danazol
- danicopan
- darunavir
- diltiazem
- diosmin
- dronedarone
- duvelisib
- erythromycin
- fedratinib
- flibanserin
- fluconazole
- fosamprenavir
- glecaprevir
- grapefruit
- imatinib
- isavuconazonium
- lapatinib
- ledipasvir
- lefamulin
- lenacapavir
- letermovir
- mavorixafor
- nilotinib
- nirogacestat
- pibrentasvir
- propafenone
- quinidine (antiarrhythmic)
- ranolazine
- tepotinib
- turmeric
- vemurafenib
- verapamil
- vimseltinib
- voxilaprevir
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn, immediate or delayed
- dyspnea
- rash, severe
Common Reactions
- nausea
- abdominal pain
- dyspepsia
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at up to 45x MRHD
Pregnancy Registry
enroll pts or encourage pts to enroll in Migraine Observational Nurtec Pregnancy Registry at 1-877-366-0324 or www.nurtecpregnancyregistry.com or email nurtecpregnancyregistry@ppd.com
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; inadequate human data available, though risk of infant harm not expected based on limited drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: 2C9, 3A4 (primary) substrate
Excretion: feces 78% (42% unchanged), urine 24% (51% unchanged); Half-life: 11h
Subclass: CGRP Inhibitors ; Headache/Migraine
Mechanism of Action
blocks calcitonin gene-related peptide (CGRP) activity
Formulary .
No Formulary Selected
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