Highlights & Basics
- Campylobacter infection is one of the leading causes of acute diarrhea worldwide and is the most commonly reported bacterial cause of acute gastroenteritis in developed countries. It is also a major cause of travelers' diarrhea.
- Campylobacter jejuni is the primary cause of acute enteritis, causing 80% to 90% of all cases of recognized illness due to Campylobacter infection. Campylobacter coli is the second most common cause of acute enteritis. Campylobacter fetus is a rare cause of extra-intestinal infection, mainly in immunocompromised people.
- Campylobacters are carried by a wide variety of wild and domestic animals, most commonly birds. Most C jejuni infections in humans come from the consumption of infected poultry.
- Diarrhea is usually self-limited and resolves in 5-7 days. Campylobacter bacteremia is very rare.
- Fluid and electrolyte replacement is essential. Only a small proportion of patients benefit from antimicrobial therapy.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Citations
World Health Organization. Campylobacter fact sheet. 1 May 2020 [internet publication]. [Full Text]
Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017 Nov 29;65(12):e45-80.[Abstract][Full Text]
Government of British Columbia. Laboratory. Nov 2023 [internet publication].[Full Text]
Riddle MS, DuPont HL, Connor BA. ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016 May;111(5):602-22.[Abstract][Full Text]
World Gastroenterology Organisation (WGO). WGO practice guideline: acute diarrhea. 2012 [internet publication].[Full Text]
1. Man SM. The clinical importance of emerging Campylobacter species. Nat Rev Gastroenterol Hepatol. 2011 Oct 25;8(12):669-85.[Abstract]
2. Kaakoush NO, Castaño-Rodríguez N, Michell HM, Man SM. Global epidemiology of Campylobacter infection. Clin Microbiol Rev. 2015 Jul;28(3):687-720.[Abstract][Full Text]
3. Centers for Disease Control and Prevention. Food safety: campylobacter. 14 April 2021 [internet publication].[Full Text]
4. Blaser MJ. Epidemiologic and clinical features of Campylobacter jejuni infections. J Infect Dis. 1997 Dec;176(suppl 2):S103-5.[Abstract][Full Text]
5. Fernández-Cruz A, Muñoz P, Mohedano R, et al. Campylobacter bacteremia: clinical characteristics, incidence, and outcome over 23 years. Medicine (Baltimore). 2010 Sep;89(5):319-30.[Abstract]
6. World Health Organization. Campylobacter fact sheet. 1 May 2020 [internet publication]. [Full Text]
7. Delahoy MJ, Shah HJ, Weller DL, et al. Preliminary incidence and trends of infections caused by pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2022. MMWR Morb Mortal Wkly Rep 2023;72:701-6.[Full Text]
8. Public Health England (UK). Research and analysis: Campylobacter data 2010 to 2019. Apr 2024 [internet publication].[Full Text]
9. European Food Safety Authority, European Centre for Disease Prevention and Control. The European union one health 2019 zoonoses report. EFSA J. 2021;19(2):6406, 286 pp.[Full Text]
10. Centers for Disease Control and Prevention. Foodborne Diseases Active Surveillance Network (FoodNet): FoodNet data. Jun 2023 [internet publication].[Full Text]
11. Skirrow MB. A demographic survey of campylobacter, salmonella, shigella infections in England: a public health laboratory service survey. Epidemiol Infect. 1987 Dec;99(3):647-57.[Abstract]
12. Green MS, Schwartz N, Peer V. Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection. BMC Infect Dis. 2020 Aug 25;20(1):625.[Abstract][Full Text]
13. Kovats RS, Edwards SJ, Charron D, et al. Climate variability and campylobacter infection: an international study. Int J Biometeorol. 2005 Mar;49(4):207-14.[Abstract]
14. Centers for Disease Control and Prevention. CDC Yellow Book 2024: traveler's health. Section 5: travel-associated infections & diseases - campylobacteriosis. May 2023 [internet publication].[Full Text]
15. Humphrey T, O'Brien S, Madsen M. Campylobacters as zoonotic pathogens: a food production perspective. Int J Food Microbiol. 2007 Jul 15;117(3):237-57.[Abstract]
16. Young KT, Davis LM, Dirita VJ. Campylobacter jejuni: molecular biology and pathogenesis. Nat Rev Microbiol. 2007 Sep;5(9):665-79.[Abstract]
17. Wagenaar JA, van Bergen MA, Blaser MJ, et al. Campylobacter fetus infections in humans: exposure and disease. Clin Infect Dis. 2014 Jun;58(11):1579-86.[Abstract][Full Text]
18. Domingues AR, Pires SM, Halasa T, et al. Source attribution of human campylobacteriosis using a meta-analysis of case-control studies of sporadic infections. Epidemiol Infect. 2012 Jun;140(6):970-81.[Abstract][Full Text]
19. van Putten JP, van Alphen LB, Wösten MM, et al. Molecular mechanisms of campylobacter infection. Curr Top Microbiol Immunol. 2009;337:197-229.[Abstract]
20. Haddad N, Marce C, Magras C, et al. An overview of methods used to clarify pathogenesis mechanisms of Campylobacter jejuni. J Food Prot. 2010 Apr;73(4):786-802.[Abstract][Full Text]
21. Dasti JI, Tareen AM, Lugert R, et al. Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-mediating mechanisms. Int J Med Microbiol. 2010 Apr;300(4):205-11.[Abstract]
22. Kapperud G, Lassen J, Ostroff SM, et al. Clinical features of sporadic Campylobacter infections in Norway. Scand J Infect Dis. 1992;24(6):741-9.[Abstract]
23. Saeed AM, Harris NV, DiGiacomo RF. The role of exposure to animals in the etiology of Campylobacter jejuni/coli enteritis. Am J Epidemiol. 1993 Jan 1;137(1):108-14.[Abstract]
24. Doorduyn Y, Van Den Brandhof WE, Van Duynhoven YT, et al. Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in The Netherlands: a case-control study. Epidemiol Infect. 2010 Oct;138(10):1391-404.[Abstract]
25. Sorvillo FJ, Lieb LE, Waterman SH. Incidence of campylobacteriosis among patients with AIDS in Los Angeles County. J Acquir Immune Defic Syndr. 1991;4(6):598-602.[Abstract]
26. Guzman-Herrador B, Carlander A, Etelberg S, et al. Waterborne outbreaks in the Nordic countries, 1998 to 2012. Euro Surveill. 2015 Jun 18;20(24):21160.[Abstract][Full Text]
27. Hinnenkamp R, Sorenson S, Evanson E, et al. Notes from the field: campylobacteriosis outbreak associated with consumption of raw water - Montana, 2022. MMWR Morb Mortal Wkly Rep 2023;72:411-2.[Full Text]
28. Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017 Nov 29;65(12):e45-80.[Abstract][Full Text]
29. Tam CC, Higgins CD, Neal KR, et al; Campylobacter Case-Control Study Group. Chicken consumption and use of acid-suppressing medications as risk factors for Campylobacter enteritis, England. Emerg Infect Dis. 2009 Sep;15(9):1402-8.[Abstract][Full Text]
30. Ejemot-Nwadiaro RI, Ehiri JE, Arikpo D, et al. Hand-washing promotion for preventing diarrhoea. Cochrane Database Syst Rev. 2021 Jan 6;12(1):CD004265.[Abstract][Full Text]
31. Havelaar AH, van Pelt W, Ang CW et al. Immunity to Campylobacter: its role in risk assessment and epidemiology. Crit Rev Microbiol. 2009;35(1):1-22.[Abstract]
32. Same RG, Tamma PD. Campylobacter infections in children. Pediatr Rev. 2018 Nov;39(11):533-41.[Abstract][Full Text]
33. White AE, Ciampa N, Chen Y, et al. Characteristics of Campylobacter and salmonella infections and acute gastroenteritis in older adults in Australia, Canada, and the United States. Clin Infect Dis. 2019 Oct 15;69(9):1545-52. [Abstract][Full Text]
34. Tribble DR, Baqar S, Scott DA, et al. Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans. Infect Immun. 2010 Apr;78(4):1750-9.[Abstract][Full Text]
35. Cover TL, Perez-Perez GI, Blaser MJ. Evaluation of cytotoxic activity in fecal filtrates from patients with Campylobacter jejuni or Campylobacter coli enteritis. FEMS Microbiol Lett. 1990 Aug;58(3):301-4.[Abstract][Full Text]
36. Government of British Columbia. Infectious diarrhea - guideline for investigation. Dec 2023 [internet publication].[Full Text]
37. Schmidt-Ott R, Schmidt H, Feldmann S, et al. Improved serological diagnosis stresses the major role of Campylobacter jejuni in triggering Guillain-Barré syndrome. Clin Vaccine Immunol. 2006 Jul;13(7):779-83.[Abstract][Full Text]
38. O'Hara GA, Fitchett JRA, Klein JL. Campylobacter bacteremia in London: a 44-year single-center study. Diagn Microbiol Infect Dis. 2017 Sep;89(1):67-71.[Abstract]
39. Herbinger KH, Hanus I, Beissner M, et al. Lymphocytosis and lymphopenia induced by imported infectious diseases: a controlled cross-sectional study of 17,229 diseased German travelers returning from the tropics and subtropics. Am J Trop Med Hyg. 2016 Jun 1;94(6):1385-91.[Abstract][Full Text]
40. Government of British Columbia. Laboratory. Nov 2023 [internet publication].[Full Text]
41. Riddle MS, DuPont HL, Connor BA. ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016 May;111(5):602-22.[Abstract][Full Text]
42. Gregorio GV, Gonzales ML, Dans LF, Martinez EG. Polymer-based oral rehydration solution for treating acute watery diarrhoea. Cochrane Database Syst Rev. 2016 Dec 13;12(12):CD006519.[Abstract][Full Text]
43. Ternhag A, Asikainen T, Giesecke J, et al. A meta-analysis on the effects of antibiotic treatment on duration of symptoms caused by infection with Campylobacter species. Clin Infect Dis. 2007 Mar 1;44(5):696-700.[Abstract]
44. World Gastroenterology Organisation (WGO). WGO practice guideline: acute diarrhea. 2012 [internet publication].[Full Text]
45. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3):804.[Abstract][Full Text]
46. Centers for Disease Control and Prevention. Antibiotic/antimicrobial resistance (AR/AMR). Nov 2021 [internet publication].[Full Text]
47. Schiaffino F, Kosek MN. Intestinal and extra-intestinal manifestations of Campylobacter in the immunocompromised host. Curr Treat Options Infect Dis. 2020;12(4):361-74.
48. Roa-Bautista A, Brown LK, Tadros S, et al. Clinical features, immunological characteristics, and treatment outcomes of Campylobacter spp. infections in patients with common variable immunodeficiency. J Allergy Clin Immunol Pract. 2023 Nov;11(11):3493-501.e4.[Abstract][Full Text]
49. Collinson S, Deans A, Padua-Zamora A, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020 Dec 8;12(12):CD003048.[Abstract][Full Text]
50. Pérez-Gaxiola G, Cuello-García CA, Florez ID, Pérez-Pico VM. Smectite for acute infectious diarrhoea in children. Cochrane Database Syst Rev. 2018 Apr 25;4(4):CD011526.[Abstract][Full Text]
51. Hlashwayo DF, Barbosa F, Langa S, et al. A systematic review of in vitro activity of medicinal plants from sub-Saharan Africa against Campylobacter spp. Evid Based Complement Alternat Med. 2020 May 15;2020:9485364.[Abstract][Full Text]
52. Hessulf F, Ljungberg J, Johansson PA, et al. Campylobacter jejuni-associated perimyocarditis: two case reports and review of the literature. BMC Infect Dis. 2016 Jun 14;16:289.[Abstract][Full Text]
53. Peterson MC. Rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults. Scand J Rheumatol. 1994;23(4):167-70.[Abstract]
54. Poropatich KO, Walker CL, Black RE. Quantifying the association between Campylobacter infection and Guillain-Barré syndrome: a systematic review. J Health Popul Nutr. 2010 Dec;28(6):545-52.[Abstract][Full Text]
Key Articles
Referenced Articles
Sign in to access our clinical decision support tools