Highlights & Basics
- The inhalation of foreign material into the airways beyond the vocal cords.
- Usually occurs in patients with altered level of consciousness, dysphagia, or impaired cough reflex.
- Patients with risk factors for aspiration should undergo a bedside clinical exam before feeding.
- Anesthesia-related aspiration of gastric contents can be prevented by identifying patients susceptible to vomiting and reflux, minimizing gastric contents before surgery, minimizing emetic stimuli, and avoiding complete loss of protective reflexes from oversedation.
- Antibiotics are not indicated early after aspiration of gastric contents but they should be considered if the pneumonitis does not resolve after 48 hours.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Bronchoscopy showing barium aspiration in a lung transplant patient in the right mainstem bronchus after a barium swallow study
A. Portable upright chest x-ray before aspiration; B. Chest x-ray 1 hour after aspiration, showing bilateral diffuse alveolar infiltrates, worse at the bases on the right side
Citations
Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med. 2001 Mar 1;344(9):665-71.[Abstract]
Ng A, Smith G. Gastroesophageal reflux and aspiration of gastric contents in anesthetic practice. Anesth Analg. 2001 Aug;93(2):494-513.[Abstract][Full Text]
Metheny NA, Clouse RE, Chang YH, et al. Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med. 2006 Apr;34(4):1007-15.[Abstract][Full Text]
Smith Hammond CA, Goldstein LB. Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(1 suppl):154S-68S.[Abstract][Full Text]
Boyd M, Chatterjee A, Chiles C, et al. Tracheobronchial foreign body aspiration in adults. South Med J. 2009 Feb;102(2):171-4.[Abstract]
Paintal HS, Kuschner WG. Aspiration syndromes: 10 clinical pearls every physician should know. Int J Clin Pract. 2007 May;61(5):846-52.[Abstract]
Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: Application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists Task Force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017 Mar;126(3):376-93.[Abstract][Full Text]
Australian and New Zealand Society for Geriatric Medicine. Australian and New Zealand Society for Geriatric Medicine. Position statement - dysphagia and aspiration in older people. Australas J Ageing. 2011 Jun;30(2):98-103.[Abstract]
1. Raghavendran K, Nemzek J, Napolitano LM, et al. Aspiration-induced lung injury. 2011 Apr;39(4):818-26.[Abstract][Full Text]
2. Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med. 2001 Mar 1;344(9):665-71.[Abstract]
3. Gray C, Sivaloganathan S, Simpkins KC. Aspiration of high-density barium contrast medium causing acute pulmonary inflammation: report of two fatal cases in elderly women with disordered swallowing. 1989 Jul;40(4):397-400.[Abstract]
4. Ng A, Smith G. Gastroesophageal reflux and aspiration of gastric contents in anesthetic practice. Anesth Analg. 2001 Aug;93(2):494-513.[Abstract][Full Text]
5. Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology. 1993 Jan;78(1):56-62.[Abstract]
6. Warner MA, Warner ME, Warner DO, et al. Perioperative pulmonary aspiration in infants and children. Anesthesiology. 1999 Jan;90(1):66-71.[Abstract]
7. Borland LM, Sereika SM, Woelfel SK, et al. Pulmonary aspiration in pediatric patients during general anesthesia: incidence and outcome. J Clin Anesth. 1998 Mar;10(2):95-102.[Abstract]
8. Olsson GL, Hallen B, Hambraeus-Jonzon K. Aspiration during anaesthesia: a computer-aided study of 185,358 anaesthetics. Acta Anaesthesiol Scand. 1986 Jan;30(1):84-92.[Abstract]
9. Lockey DJ, Coats T, Parr MJ. Aspiration in severe trauma: a prospective study. Anaesthesia. 1999 Nov;54(11):1097-8. [Abstract][Full Text]
10. Mullan H, Roubenoff RA, Roubenoff R. Risk of pulmonary aspiration among patients receiving enteral nutrition support. JPEN J Parenter Enteral Nutr. Mar-Apr 1992;16(2):160-4.[Abstract]
11. Metheny NA, Clouse RE, Chang YH, et al. Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med. 2006 Apr;34(4):1007-15.[Abstract][Full Text]
12. Fung KP, Seagram G, Pasieka J, et al. Investigation and outcome of 121 infants and children requiring Nissen fundoplication for the management of gastroesophageal reflux. Clin Invest Med. 1990 Oct;13(5):237-46.[Abstract]
13. Tamm I, Kortsik C. Severe barium sulfate aspiration into the lung: clinical presentation, prognosis and therapy. Respiration. 1999;66(1):81-4.[Abstract]
14. Ansell G. Alimentary tract. In: Ansell G, Bettmann MA, Kaufman JA, et al, eds. Complications in diagnostic imaging and interventional radiology. 2nd ed. Oxford, UK: Blackwell Scientific; 1987:218-9.
15. Smith Hammond CA, Goldstein LB. Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(1 suppl):154S-68S.[Abstract][Full Text]
16. McClave SA, Lukan JK, Stefater JA, et al. Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med. 2005 Feb;33(2):324-30.[Abstract]
17. Boyd M, Chatterjee A, Chiles C, et al. Tracheobronchial foreign body aspiration in adults. South Med J. 2009 Feb;102(2):171-4.[Abstract]
18. Shaker R, Li Q, Ren J, et al. Coordination of deglutition and phases of respiration: effect of aging, tachypnea, bolus volume, and chronic obstructive pulmonary disease. Am J Physiol. 1992 Nov;263(5 Pt 1):G750-5.[Abstract]
19. Vaughan GG, Grycko RJ, Montgomery MT. The prevention and treatment of aspiration of vomitus during pharmacosedation and general anesthesia. J Oral Maxillofac Surg. 1992 Aug;50(8):874-9.[Abstract]
20. Royal College of Obstetricians and Gynaecologists. Maternal collapse in pregnancy and the puerperium. Green-top Guideline No. 56. Dec 2019 [internet publication].[Full Text]
21. Abou Jaoude P, Knight PR, Ohtake P, et al. Biomarkers in the diagnosis of aspiration syndromes. Expert Rev Mol Diagn. 2010 Apr;10(3):309-19. [Abstract][Full Text]
22. Green SM, Krauss B. Pulmonary aspiration risk during emergency department procedural sedation: an examination of the role of fasting and sedation depth. Acad Emerg Med. 2002 Jan;9(1):35-42.[Abstract]
23. Wick R, Gilbert JD, Byard RW. Café coronary syndrome - fatal choking on food: an autopsy approach. J Clin Forensic Med. 2006 Apr;13(3):135-8.[Abstract]
24. Mizock BA. Risk of aspiration in patients on enteral nutrition: frequency, relevance, relation to pneumonia, risk factors, and strategies for risk reduction. Curr Gastroenterol Rep. 2007 Aug;9(4):338-44.[Abstract]
25. Lundy DS, Smith C, Colangelo L, et al. Aspiration: cause and implications. Otolaryngol Head Neck Surg. 1999 Apr;120(4):474-8.[Abstract]
26. Elpern EH, Scott MG, Petro L, et al. Pulmonary aspiration in mechanically ventilated patients with tracheostomies. Chest. 1994 Feb;105(2):563-6. [Abstract]
27. Elpern EH, Jacobs ER, Bone RC. Incidence of aspiration in tracheally intubated adults. Heart Lung. 1987 Sep;16(5):527-31.[Abstract]
28. Paintal HS, Kuschner WG. Aspiration syndromes: 10 clinical pearls every physician should know. Int J Clin Pract. 2007 May;61(5):846-52.[Abstract]
29. Fernández-Carmona A, Peñas-Maldonado L, Yuste-Osorio E, et al. Exploration and approach to artificial airway dysphagia. Med Intensiva. Aug-Sep 2012;36(6):423-33.[Abstract]
30. Leder SB, Cohn SM, Moller BA. Fiberoptic endoscopic documentation of the high incidence of aspiration following extubation in critically ill trauma patients. Dysphagia. Fall 1998;13(4):208-12. [Abstract][Full Text]
31. Langmore SE, Terpenning MS, Schork A, et al. Predictors of aspiration pneumonia: how important is dysphagia? Dysphagia. Spring 1998;13(2):69-81. [Abstract]
32. Soreide E, Eriksson LI, Hirlekar G, et al. Pre-operative fasting guidelines: an update. Acta Anaesthesiol Scand. 2005 Sep;49(8):1041-7.[Abstract][Full Text]
33. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: Application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists Task Force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017 Mar;126(3):376-93.[Abstract][Full Text]
34. Smith I, Kranke P, Murat I, et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2011 Aug;28(8):556-69.[Abstract][Full Text]
35. Healthcare Infection Control Practices Advisory Committee; Centers for Disease Control and Prevention (US). Guidelines for preventing health-care-associated pneumonia, 2003 recommendations of the CDC and the Healthcare Infection Control Practices Advisory Committee. Respir Care. 2004 Aug;49(8):926-39.[Abstract][Full Text]
36. Chiu CY, Wong KS, Tsai MH. Massive aspiration of barium sulfate during an upper gastrointestinal examination in a child with dysphagia. Int J Pediatr Otorhinolaryngol. 2005 Apr;69(4):541-4.[Abstract]
37. Basu S, Kumar A, Das BK. Accidental aspiration of barium sulphate in an infant. Pediatr Radiol. 2009 Jul;39(7):762.[Abstract]
38. Franquet T, Gimenez A, Roson N, et al. Aspiration diseases: findings, pitfalls, and differential diagnosis. Radiographics. May-Jun 2000;20(3):673-85. [Abstract][Full Text]
39. Schwarz MI, Albert RK. "Imitators" of the ARDS: implications for diagnosis and treatment. Chest. 2004 Apr;125(4):1530-5.[Abstract]
40. Bynum LJ, Pierce AK. Pulmonary aspiration of gastric contents. Am Rev Respir Dis. 1976 Dec;114(6):1129-36.[Abstract]
41. Bernard GR. Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med. 2005 Oct 1;172(7):798-806.[Abstract][Full Text]
42. Martinati LC, Boner AL. Clinical diagnosis of wheezing in early childhood. Allergy. 1995 Sep;50(9):701-10.[Abstract]
43. Fireman P. The wheezing infant. Pediatr Rev. 1986 Feb;7(8):247-54.[Abstract]
44. Davie AP, Francis CM, Caruana L, et al. Assessing diagnosis in heart failure: which features are any use? QJM. 1997 May;90(5):335-9. [Abstract][Full Text]
45. Marcus GM, Gerber IL, McKeown BH, et al. Association between phonocardiographic third and fourth heart sounds and objective measures of left ventricular function. JAMA. 2005 May 11;293(18):2238-44.[Abstract][Full Text]
46. Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002 Jul 18;347(3):161-7.[Abstract][Full Text]
47. National Safety Council. Leading causes of death: an excerpt of injury facts. Itasca, IL: National Safety Council Press; 2003:10-15.
48. Colice GL, Matthay MA, Bass E, et al. Neurogenic pulmonary edema. Am Rev Respir Dis. 1984 Nov;130(5):941-8. [Abstract]
49. Brodsky MB, Suiter DM, González-Fernández M, et al. Screening accuracy for aspiration using bedside water swallow tests: a systematic review and meta-analysis. Chest. 2016 Jul;150(1):148-63. [Abstract][Full Text]
50. Doggett DL, Tappe KA, Mitchell MD, et al. Prevention of pneumonia in elderly stroke patients by systematic diagnosis and treatment of dysphagia: an evidence-based comprehensive analysis of the literature. Dysphagia. Fall 2001;16(4):279-95. [Abstract]
51. Marik PE, Kaplan D. Aspiration pneumonia and dysphagia in the elderly. Chest. 2003 Jul;124(1):328-36. [Abstract]
52. Odderson IR, Keaton JC, McKenna BS. Swallow management in patients on an acute stroke pathway: quality is cost effective. Arch Phys Med Rehabil. 1995 Dec;76(12):1130-3. [Abstract][Full Text]
53. Scottish Intercollegiate Guidelines Network. Management of patients with stroke: identification and management of dysphagia - a national clinical guideline. June 2010 [internet publication].[Full Text]
54. Australian and New Zealand Society for Geriatric Medicine. Australian and New Zealand Society for Geriatric Medicine. Position statement - dysphagia and aspiration in older people. Australas J Ageing. 2011 Jun;30(2):98-103.[Abstract]
55. American College of Radiology. ACR appropriateness criteria: dysphagia. 2018 [internet publication].[Full Text]
56. Daniels SK, Brailey K, Priestly DH, et al. Aspiration in patients with acute stroke. Arch Phys Med Rehabil. 1998 Jan;79(1):14-9.[Abstract][Full Text]
57. Dines DE, Titus JL, Sessler AD. Aspiration pneumonitis. Mayo Clin Proc. 1970 May;45(5):347-60.[Abstract]
58. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-67.[Abstract][Full Text]
59. Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016 Sep 1;63(5):e61-111.[Abstract][Full Text]
60. Daoud E, Guzman J. Q: Are antibiotics indicated for the treatment of aspiration pneumonia? Cleve Clin J Med. 2010 Sep;77(9):573-6.[Abstract]
61. European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. 15 November 2018 [internet publication]. [Full Text]
62. Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. 21 March 2019 [internet publication]. [Full Text]
63. US Food & Drug Administration. FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. 26 July 2016 [internet publication]. [Full Text]
64. US Food & Drug Administration. FDA Drug Safety Communication: FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. 20 December 2018 [internet publication].[Full Text]
65. US Food & Drug Administration. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. 10 July 2018 [internet publication].[Full Text]
66. Wolfe JE, Bone RC, Ruth WE. Effects of corticosteroids in the treatment of patients with gastric aspiration. Am J Med. 1977 Nov;63(5):719-22. [Abstract]
67. Sukumaran M, Granada MJ, Berger HW, et al. Evaluation of corticosteroid treatment in aspiration of gastric contents: a controlled clinical trial. Mt Sinai J Med. Jul-Aug 1980;47(4):335-40.[Abstract]
68. Lee M, Sukumaran M, Berger HW, et al. Influence of corticosteroid treatment on pulmonary function after recovery from aspiration of gastric contents. Mt Sinai J Med. Jul-Aug 1980;47(4):341-6.[Abstract]
69. Voloudaki A, Ergazakis N, Gourtsoyiannis N. Late changes in barium sulfate aspiration: HRCT features. Eur Radiol. 2003 Sep;13(9):2226-9. [Abstract]
70. McClave SA, Snider HL. Clinical use of gastric residual volumes as a monitor for patients on enteral tube feeding. JPEN J Parenter Enteral Nutr. Nov-Dec 2002;26(6 suppl):S43-8;discussion S49-50.[Abstract]
71. Brady M, Kinn S, Stuart P, et al. Preoperative fasting for adults to prevent perioperative complications. Cochrane Database Syst Rev. 2003 Oct 20;(4):CD004423.[Abstract][Full Text]
72. The American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002 Apr;96(4):1004-17.[Abstract]
73. Thorpe RJ, Benger J. Pre-procedural fasting in emergency sedation. Emerg Med J. 2010 Apr;27(4):254-61.[Abstract]
74. Paranjothy S, Griffiths JD, Broughton HK, et al. Interventions at caesarean section for reducing the risk of aspiration pneumonitis. Cochrane Database Syst Rev. 2014 Feb 5;(2):CD004943.[Abstract][Full Text]
75. Gyte GM, Richens Y. Routine prophylactic drugs in normal labour for reducing gastric aspiration and its effects. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005298.[Abstract][Full Text]
76. Clark K, Lam LT, Gibson S, et al. The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials. Anaesthesia. 2009 Jun;64(6):652-7. [Abstract][Full Text]
77. Puig I, Calzado S, Suárez D, Sánchez-Delgado J, López S, Calvet X. Meta-analysis: comparative efficacy of H2-receptor antagonists and proton pump inhibitors for reducing aspiration risk during anaesthesia depending on the administration route and schedule. Pharmacol Res. 2012 Apr;65(4):480-90. [Abstract]
78. van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med. 2006 Feb;34(2):396-402.[Abstract]
79. El Solh AA, Saliba R. Pharmacologic prevention of aspiration pneumonia: a systematic review. Am J Geriatr Pharmacother. 2007 Dec;5(4):352-62.[Abstract]
80. Wang D, Zheng SQ, Chen XC, et al. Comparisons between small intestinal and gastric feeding in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. J Neurosurg. 2015 Nov;123(5):1194-201.[Abstract][Full Text]
81. Warusevitane A, Karunatilake D, Sim J, et al. Safety and effect of metoclopramide to prevent pneumonia in patients with stroke fed via nasogastric tubes trial. Stroke. 2015 Feb;46(2):454-60. [Abstract][Full Text]
82. Pace CC, McCullough GH. The association between oral microorganisms and aspiration pneumonia in the institutionalized elderly: review and recommendations. Dysphagia. 2010 Dec;25(4):307-22. [Abstract][Full Text]
83. Rasley A, Logemann JA, Kahrilas PJ, et al. Prevention of barium aspiration during videofluoroscopic swallowing studies: value of change in posture. AJR Am J Roentgenol. 1993 May;160(5):1005-9.[Abstract][Full Text]
84. Dennis MS, Lewis SC, Warlow C; FOOD Trial Collaboration. Routine oral nutritional supplementation for stroke patients in hospital (FOOD): a multicentre randomised controlled trial. Lancet. 2005 Feb 26-Mar 4;365(9461):755-63.[Abstract]
85. Dennis MS, Lewis SC, Warlow C; FOOD Trial Collaboration. Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial. Lancet. 2005 Feb 26-Mar 4;365(9461):764-72.[Abstract]
86. Park RH, Allison MC, Lang J, et al. Randomised comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding in patients with persisting neurological dysphagia. BMJ. 1992 May 30;304(6839):1406-9. [Abstract][Full Text]
87. Strong RM, Condon SC, Solinger MR, et al. Equal aspiration rates from postpylorus and intragastric-placed small-bore nasoenteric feeding tubes: a randomized, prospective study. JPEN J Parenter Enteral Nutr. Jan-Feb 1992;16(1):59-63.[Abstract]
88. Spain DA, DeWeese RC, Reynolds MA, et al. Transpyloric passage of feeding tubes in patients with head injuries does not decrease complications. J Trauma. 1995 Dec;39(6):1100-2. [Abstract]
89. Alkhawaja S, Martin C, Butler RJ, et al. Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults. Cochrane Database Syst Rev. 2015 Aug 4;(8):CD008875.[Abstract][Full Text]
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