Highlights & Basics
- Alcohol withdrawal is caused by the abrupt cessation of alcohol consumption in patients with alcohol dependence or chronic alcoholism.
- The clinical presentation consists of a spectrum of signs and symptoms, including autonomic hyperactivity, tremulousness, restlessness, seizures, and potentially life-threatening alcohol withdrawal delirium.
- Alcohol withdrawal syndrome is a clinical diagnosis.
- Symptom-triggered therapy with benzodiazepines remains the cornerstone of management.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
Bayard M, McIntyre J, Hill KR, et al. Alcohol withdrawal syndrome. Am Fam Physician. 2004 Mar 15;69(6):1443-50.[Abstract][Full Text]
American Society of Addiction Medicine. The ASAM clinical practice guideline on alcohol withdrawal management. J Addict Med. 2020 May/Jun;14(3s suppl 1):1-72.[Abstract][Full Text]
Bråthen G, Ben-Menachem E, Brodtkorb E, et al. Chapter 29: alcohol-related seizures. EFNS guidelines of alcohol-related seizures. In: Gilhus NE, Barnes MP, Brainin M, eds. European handbook of neurological management. 2nd ed, v1. Oxford, UK: Blackwell Publishing; 2011:429-36.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed. Text revision. (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
1. Bayard M, McIntyre J, Hill KR, et al. Alcohol withdrawal syndrome. Am Fam Physician. 2004 Mar 15;69(6):1443-50.[Abstract][Full Text]
2. Parker AJ, Marshall EJ, Ball DM. Diagnosis and management of alcohol use disorders. BMJ. 2008 Mar 1;336(7642):496-501.[Abstract][Full Text]
3. Stewart S, Swain S, NICE; Royal College of Physicians, London. Assessment and management of alcohol dependence and withdrawal in the acute hospital: concise guidance. Clin Med (Lond). 2012 Jun;12(3):266-71.[Abstract][Full Text]
4. Hall W, Zador D. The alcohol withdrawal syndrome. Lancet. 1997 Jun 28;349(9069):1897-900.[Abstract]
5. American Society of Addiction Medicine. The ASAM clinical practice guideline on alcohol withdrawal management. J Addict Med. 2020 May/Jun;14(3s suppl 1):1-72.[Abstract][Full Text]
6. Tiglao SM, Meisenheimer ES, Oh RC. Alcohol withdrawal syndrome: outpatient management. Am Fam Physician. 2021 Sep 1;104(3):253-62.[Abstract][Full Text]
7. Bråthen G, Ben-Menachem E, Brodtkorb E, et al. Chapter 29: alcohol-related seizures. EFNS guidelines of alcohol-related seizures. In: Gilhus NE, Barnes MP, Brainin M, eds. European handbook of neurological management. 2nd ed, v1. Oxford, UK: Blackwell Publishing; 2011:429-36.
8. National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis and clinical management of alcohol-related physical complications. Apr 2017 [internet publication].[Full Text]
9. Reus VI, Fochtmann LJ, Bukstein O, et al. The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder. Am J Psychiatry. 2018 Jan 1;175(1):86-90.[Abstract]
10. McMicken DB, Finnell JT. Alcohol related disease. In: Rosen's emergency medicine: concepts and clinical practice. 6th ed. St. Louis, MO: Mosby, Inc; 2006:184.
11. Schuckit MA. Recognition and management of withdrawal delirium (delirium tremens). N Engl J Med. 2014 Nov 27;371(22):2109-13.[Abstract]
12. Day E, Copello A, Hull M. Assessment and management of alcohol use disorders. BMJ. 2015 Feb 19;350:h715.[Abstract]
13. World Health Organization. Global status report on alcohol and health 2018. Sep 2018 [internet publication].[Full Text]
14. US Department of Health and Human Services: Substance Abuse and Mental Health Services Administration (SAMHSA). Reports and detailed tables from the 2020 National survey on drug use and health (NSDUH). Oct 2021 [internet publication].[Full Text]
15. Schmidt KJ, Doshi MR, Holzhausen JM, et al. Treatment of severe alcohol withdrawal. Ann Pharmacother. 2016 May;50(5):389-401.[Abstract]
16. Foy A, Kay J. The incidence of alcohol-related problems and the risk of alcohol withdrawal in a general hospital population. Drug Alcohol Rev. 1995;14(1):49-54.[Abstract]
17. Foy A. Alcohol problems in a general hospital. Addict Biol. 1999;4(1):23-34.[Abstract]
18. Dixit D, Endicott J, Burry L, et al. Management of acute alcohol withdrawal syndrome in critically ill patients. Pharmacotherapy. 2016 Jul;36(7):797-822.[Abstract]
19. Uusaro A, Parviainen I, Tenhunen JJ, et al. The proportion of intensive care unit admissions related to alcohol use: a prospective cohort study. Acta Anaesthesiol Scand. 2005 Oct;49(9):1236-40.[Abstract]
20. Ungur LA, Neuner B, John S, et al. Prevention and therapy of alcohol withdrawal on intensive care units: systematic review of controlled trials. Alcohol Clin Exp Res. 2013 Apr;37(4):675-86.[Abstract]
21. Lukan JK, Reed DN Jr, Looney SW, et al. Risk factors for delirium tremens in trauma patients. J Trauma. 2002 Nov;53(5):901-6.[Abstract]
22. Jawa RS, Stothert JC, Shostrom VK, et al. Alcohol withdrawal syndrome in admitted trauma patients. Am J Surg. 2014 Nov;208(5):781-7.[Abstract]
23. Salottolo K, McGuire E, Mains CW, et al. Occurrence, predictors, and prognosis of alcohol withdrawal syndrome and delirium tremens following traumatic injury. Crit Care Med. 2017 May;45(5):867-74.[Abstract]
24. Gold JA, Nelson LS. Chapter 81: ethanol withdrawal. In: Hoffman RS, Howland MA, Lewin NA, et al, eds. Goldfrank's toxicologic emergencies, 10th edition. Columbus, OH: McGraw Hill Professional; 2015:1108-13.
25. Stehman CR, Mycyk MB. A rational approach to the treatment of alcohol withdrawal in the ED. Am J Emerg Med. 2013 Apr;31(4):734-42.[Abstract]
26. Sarff M, Gold JA. Alcohol withdrawal syndromes in the intensive care unit. Crit Care Med. 2010 Sep;38(9 Suppl):S494-501.[Abstract]
27. Isbell H, Fraser HF, Wikler A, et al. An experimental study of the etiology of rum fits and delirium tremens. Q J Stud Alcohol. 1955 Mar;16(1):1-33.[Abstract]
28. Linnoila M, Mefford I, Nutt D, et al. RNIH conference. Alcohol withdrawal and noradrenergic function. Ann Intern Med. 1987 Dec;107(6):875-89.[Abstract]
29. Brousse G, Arnaud B, Vorspan F, et al. Alteration of glutamate/GABA balance during acute alcohol withdrawal in emergency department: a prospective analysis. Alcohol Alcohol. 2012 Sep-Oct;47(5):501-8.[Abstract][Full Text]
30. Roberto M, Varodayan FP. Synaptic targets: chronic alcohol actions. Neuropharmacology. 2017 Aug 1;122:85-99.[Abstract][Full Text]
31. Littleton J. Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res World. 1998;22(1):13-24.[Abstract]
32. Lovinger DM, Roberto M. Synaptic effects induced by alcohol. Curr Top Behav Neurosci. 2013;13:31-86.[Abstract][Full Text]
33. Melendez RI, Hicks MP, Cagle SS, et al. Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res. 2005 Mar;29(3):326-33.[Abstract]
34. Dahchour A, De Witte P. Effect of repeated ethanol withdrawal on glutamate microdialysate in the hippocampus. Alcohol Clin Exp Res. 1999 Oct;23(10):1698-703.[Abstract]
35. Kelm MK, Criswell HE, Breese GR. Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Brain Res Rev. 2011 Jan 1;65(2):113-23.[Abstract][Full Text]
36. Kelm MK, Criswell HE, Breese GR. The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. J Neurophysiol. 2008 Dec;100(6):3417-28.[Abstract][Full Text]
37. Becker HC. Kindling in alcohol withdrawal. Alcohol Health Res World. 1998;22(1):25-33.[Abstract]
38. Ballenger JC, Post RM. Kindling as a model for alcohol withdrawal syndromes. Br J Psychiatry. 1978 Jul;133:1-14.[Abstract]
39. Brown ME, Anton RF, Malcolm R, et al. Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psychiatry. 1988 Mar 1;23(5):507-14.[Abstract]
40. Booth BM, Blow FC. The kindling hypothesis: further evidence from a U.S. national study of alcoholic men. Alcohol Alcohol. 1993 Sep;28(5):593-8.[Abstract]
41. McCown TJ, Breese GR. Multiple withdrawals from chronic ethanol "kindles" inferior collicular seizure activity: evidence for kindling of seizures associated with alcoholism. Alcohol Clin Exp Res. 1990 Jun;14(3):394-9.[Abstract]
42. Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014 Oct;38(10):2664-77.[Abstract]
43. Crabb DW, Im GY, Szabo G, et al. Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2020 Jan;71(1):306-33.[Abstract][Full Text]
44. Willenbring ML, Massey SH, Gardner MB. Helping patients who drink too much: an evidence-based guide for primary care clinicians. Am Fam Physician. 2009 Jul 1;80(1):44-50.[Abstract][Full Text]
45. Raistrick D, Bradshaw J, Tober G, et al. Development of the Leeds Dependence Questionnaire (LDQ): a questionnaire to measure alcohol and opiate dependence in the context of a treatment evaluation package. Addiction. 1994 May;89(5):563-72.[Abstract]
46. Stockwell T, Hodgson R, Edwards G, et al. The development of a questionnaire to measure severity of alcohol dependence. Br J Addict Alcohol Other Drugs. 1979 Mar;74(1):79-87.[Abstract]
47. Bråthen G, Ben-Menachem E, Brodtkorb E, et al. EFNS guideline on the diagnosis and management of alcohol-related seizures: report of an EFNS task force. Eur J Neurol. 2005 Aug;12(8):575-81.[Abstract][Full Text]
48. US Preventive Services Task Force, Curry SJ, Krist AH, et al. Screening and behavioral counseling interventions to reduce unhealthy alcohol use in adolescents and adults: US Preventive Services Task Force recommendation statement. JAMA. 2018 Nov 13;320(18):1899-909.[Abstract][Full Text]
49. Maldonado JR, Sher Y, Ashouri JF, et al. The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol. 2014 Jun;48(4):375-90.[Abstract]
50. Wood E, Albarqouni L, Tkachuk S, et al. Will this hospitalized patient develop severe alcohol withdrawal syndrome?: The rational clinical examination systematic review. JAMA. 2018 Aug 28;320(8):825-33.[Abstract]
51. O'Connor P. Alcohol abuse and dependence. In: Goldman L, Ausiello D. eds. Cecil textbook of medicine. 22nd ed. St. Louis, MO: W.B. Saunders Company; 2004:17.
52. Kosten TR, O'Connor PG. Management of drug and alcohol withdrawal. N Engl J Med. 2003 May 1;348(18):1786-95.[Abstract]
53. Rastegar DA, Applewhite D, Alvanzo AAH, et al. Development and implementation of an alcohol withdrawal protocol using a 5-item scale, the Brief Alcohol Withdrawal Scale (BAWS). Subst Abus. 2017 Jul 12;38(4):394-400.[Abstract]
54. McPherson A, Benson G, Forrest EH. Appraisal of the Glasgow assessment and management of alcohol guideline: a comprehensive alcohol management protocol for use in general hospitals. QJM. 2012 Jul;105(7):649-56.[Abstract][Full Text]
55. Pryse-Phillips W, Murray TJ, Boyd J. Toxic damage to the nervous system. In: Noble J, Greene H. eds. Textbook of primary care medicine. 3rd ed. St. Louis, MO: Mosby, Inc; 2001:1569.
56. Alcohol withdrawal. In: Moore DP, Jefferson JW, eds. Handbook of medical psychiatry. 2nd ed. Philadelphia, PA: Elsevier-Mosby; 2004:49.
57. Victor M, Adams RD. The effect of alcohol on the nervous system. Res Publ Assoc Res Nerv Ment Dis. 1953;32:526-73.[Abstract]
58. Victor M, Brausch C. The role of abstinence in the genesis of alcoholic epilepsy. Epilepsia. 1967 Mar;8(1):1-20.[Abstract]
59. Chang PH, Steinberg MB. Alcohol withdrawal. Med Clin North Am. 2001 Sep;85(5):1191-212.[Abstract]
60. Victor M, Hope JM. The phenomenon of auditory hallucinations in chronic alcoholism; a critical evaluation of the status of alcoholic hallucinosis. J Nerv Ment Dis. 1958 May;126(5):451-81.[Abstract]
61. Delirium tremens. In: Moore DP, Jefferson JW, eds. Handbook of medical psychiatry. 2nd ed. Philadelphia, PA: Elsevier-Mosby; 2004:50.
62. Niemelä O. Biomarkers in alcoholism. Clin Chim Acta. 2007 Feb;377(1-2):39-49.[Abstract]
63. Roffman JL, Stern TA. Alcohol withdrawal in the setting of elevated blood alcohol levels. Prim Care Companion J Clin Psychiatry. 2006;8(3):170-3.[Abstract][Full Text]
64. Schwartz NS, Clutter WE, Shah SD, et al. Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest. 1987 Mar;79(3):777-81.[Abstract][Full Text]
65. Hepburn DA, Deary IJ, Frier BM, et al. Symptoms of acute insulin-induced hypoglycemia in humans with and without IDDM. Factor-analysis approach. Diabetes Care. 1991 Nov;14(11):949-57.[Abstract]
66. Torvik A, Lindboe CF, Rogde S. Brain lesions in alcoholics: a neuropathological study with clinical correlations. J Neurol Sci. 1982 Nov;56(2-3):233-48.[Abstract]
67. Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry. 1986 Apr;49(4):341-5.[Abstract]
68. Miller TB, Geraci EB. Head injury in the presence of alcohol intoxication. Int J Trauma Nurs. 1997 Apr-Jun;3(2):50-5.[Abstract]
69. Chiang C, Wax PM. Withdrawal syndromes. In: Ford MD, ed. Clinical toxicology. 1st ed. St. Louis, MO: W.B. Saunders Company; 2001.
70. Dillman WH. Chapter 239: the thyroid. In: Goldman L, Ausiello D, Bennett JC, et al, eds. Cecil textbook of medicine. 22nd ed. St. Louis, MO: W.B. Saunders Company; 2004.
71. World Health Organization. ICD-11: International classification of diseases 11th Revision [internet publication].[Full Text]
72. Conley RR, Kelley DL. Schizophrenia. In: Rakel RE. ed. Conn's current therapy. 58th ed. Philadelphia, PA: Elsevier; 2006.
73. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed. Text revision. (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
74. Hasin D, Katz H. Somatoform and substance use disorders. Psychosom Med. 2007 Dec;69(9):870-5.[Abstract]
75. Lipowski ZJ. Somatization: the experience and communication of psychological distress as somatic symptoms. Psychother Psychosom. 1987;47(3-4):160-7.[Abstract]
76. Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Br J Addict. 1989 Nov;84(11):1353-7.[Abstract]
77. Rappaport D, Chuu A, Hullett C, et al. Assessment of alcohol withdrawal in Native American patients utilizing the Clinical Institute Withdrawal Assessment of Alcohol Revised Scale. J Addict Med. 2013 May-Jun;7(3):196-9.[Abstract]
78. Sen S, Grgurich P, Tulolo A, et al. A symptom-triggered benzodiazepine protocol utilizing SAS and CIWA-Ar scoring for the treatment of alcohol withdrawal syndrome in the critically ill. Ann Pharmacother. 2017 Feb;51(2):101-10.[Abstract]
79. Awissi DK, Lebrun G, Coursin DB, et al. Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentary. Intensive Care Med. 2013 Jan;39(1):16-30.[Abstract]
80. Maldonado JR, Sher Y, Das S, et al. Prospective validation study of the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) in medically ill inpatients: a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol Alcohol. 2015 May 21;50(5):509-18.[Abstract][Full Text]
81. Williams N. The FAST questionnaire. Occup Med (Lond). 2014 Oct;64(7):559-60.[Abstract][Full Text]
82. Ewing JA. Detecting alcoholism. The CAGE questionnaire. JAMA. 1984 Oct 12;252(14):1905-7.[Abstract]
83. Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. Prescrire Int. 2007 Feb;16(87):24-31.[Abstract]
84. Stephens JR, Liles EA, Dancel R, et al. Who needs inpatient detox? Development and implementation of a hospitalist protocol for the evaluation of patients for alcohol detoxification. J Gen Intern Med. 2014 Apr;29(4):587-93.[Abstract]
85. Martin K, Katz A. The role of barbiturates for alcohol withdrawal syndrome. Psychosomatics. 2016 Jul-Aug;57(4):341-7.[Abstract]
86. Brotherton AL, Hamilton EP, Kloss HG, et al. Propofol for treatment of refractory alcohol withdrawal syndrome: a review of the literature. Pharmacotherapy. 2016 Apr;36(4):433-42.[Abstract]
87. Hack JB, Hoffmann RS, Nelson LS. Resistant alcohol withdrawal: does an unexpectedly large sedative requirement identify these patients early? J Med Toxicol. 2006 Jun;2(2):55-60.[Abstract]
88. Kattimani S, Bharadwaj B. Clinical management of alcohol withdrawal: a systematic review. Ind Psychiatry J. 2013 Jul;22(2):100-8.[Abstract][Full Text]
89. Long D, Long B, Koyfman A. The emergency medicine management of severe alcohol withdrawal. Am J Emerg Med. 2017 Jul;35(7):1005-11.[Abstract]
90. Amato L, Minozzi S, Davoli M. Efficacy and safety of pharmacological interventions for the treatment of the alcohol withdrawal syndrome. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD008537.[Abstract][Full Text]
91. Ebell MH. Benzodiazepines for alcohol withdrawal. Am Fam Physician. 2006 Apr 1;73(7):1191.[Abstract]
92. Amato L, Minozzi S, Vecchi S, et al. Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev. 2010 Mar 17;(3):CD005063.[Abstract][Full Text]
93. Scheuermeyer FX, Miles I, Lane DJ, et al. Lorazepam versus diazepam in the management of emergency department patients with alcohol withdrawal. Ann Emerg Med. 2020 Dec;76(6):774-81.[Abstract]
94. Wang SH, Chen WS, Tang SE, et al. Benzodiazepines associated with acute respiratory failure in patients with obstructive sleep apnea. Front Pharmacol. 2019 Jan 7;9:1513.[Abstract][Full Text]
95. Skinner RT. Symptom-triggered vs. fixed-dosing management of alcohol withdrawal syndrome. Medsurg Nurs. 2014 Sep-Oct;23(5):307-15, 329.[Abstract]
96. Gold JA, Rimal B, Nolan A, et al. A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens. Crit Care Med. 2007 Mar;35(3):724-30.[Abstract][Full Text]
97. Hammond DA, Rowe JM, Wong A, et al. Patient outcomes associated with phenobarbital use with or without benzodiazepines for alcohol withdrawal syndrome: a systematic review. Hosp Pharm. 2017 Jul 17;52(9):607-16.[Abstract][Full Text]
98. Rosenson J, Clements C, Simon B, et al. Phenobarbital for acute alcohol withdrawal: a prospective randomized double-blind placebo-controlled study. J Emerg Med. 2013 Mar;44(3):592-8.e2.[Abstract]
99. Sullivan SM, Dewey BN, Jarrell DH, et al. Comparison of phenobarbital-adjunct versus benzodiazepine-only approach for alcohol withdrawal syndrome in the emergency department. Am J Emerg Med. 2018 Oct 11;S0735-6757(18)30821-0.[Abstract]
100. Gaertner J, Fusi-Schmidhauser T. Dexmedetomidine: a magic bullet on its way into palliative care-a narrative review and practice recommendations. Ann Palliat Med. 2022 Apr;11(4):1491-504.[Abstract][Full Text]
101. Mueller SW, Preslaski CR, Kiser TH, et al. A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal. Crit Care Med. 2014 May;42(5):1131-9.[Abstract]
102. Woods AD, Giometti R, Weeks SM. The use of dexmedetomidine as an adjuvant to benzodiazepine-based therapy to decrease the severity of delirium in alcohol withdrawal in adult intensive care unit patients: a systematic review. JBI Database System Rev Implement Rep. 2015 Jan;13(1):224-52.[Abstract]
103. Shehabi Y, Serpa Neto A, Howe BD, et al. Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. Intensive Care Med. 2021 Apr;47(4):455-66.[Abstract][Full Text]
104. Sohraby R, Attridge RL, Hughes DW. Use of propofol-containing versus benzodiazepine regimens for alcohol withdrawal requiring mechanical ventilation. Ann Pharmacother. 2014 Apr;48(4):456-61.[Abstract]
105. Wong A, Benedict NJ, Lohr BR, et al. Management of benzodiazepine-resistant alcohol withdrawal across a healthcare system: benzodiazepine dose-escalation with or without propofol. Drug Alcohol Depend. 2015 Sep 1;154:296-9.[Abstract]
106. Prince V, Turpin KR. Treatment of alcohol withdrawal syndrome with carbamazepine, gabapentin, and nitrous oxide. Am J Health Syst Pharm. 2008 Jun 1;65(11):1039-47.[Abstract]
107. Andaluz A, DeMoss D, Claassen C, et al. Fixed-dose gabapentin augmentation in the treatment of alcohol withdrawal syndrome: a retrospective, open-label study. Am J Drug Alcohol Abuse. 2020;46(1):49-57.[Abstract]
108. Anton RF, Latham P, Voronin K, et al. Efficacy of gabapentin for the treatment of acohol use disorder in patients with alcohol withdrawal symptoms: a randomized clinical trial. JAMA Intern Med. 2020 May 1;180(5):728-36.[Abstract][Full Text]
109. Levine AR, Carrasquillo L, Mueller J, et al. High-dose gabapentin for the treatment of severe alcohol withdrawal syndrome: a retrospective cohort analysis. Pharmacotherapy. 2019 Sep;39(9):881-8.[Abstract]
110. Myrick H, Malcolm R, Randall PK, et al. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res. 2009 Sep;33(9):1582-8.[Abstract]
111. Barrons R, Roberts N. The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome. J Clin Pharm Ther. 2010 Apr;35(2):153-67.[Abstract][Full Text]
112. Liu J, Wang LN. Baclofen for alcohol withdrawal. Cochrane Database Syst Rev. 2019 Nov 6;2019(11):CD008502.[Abstract][Full Text]
113. Alcoholism and alcohol abuse (alcohol dependence, DSM-1V 303.90; alcohol abuse, DSM-1V 305.00). In: Moore DP, Jefferson JW, eds. Handbook of medical psychiatry. 2nd ed. Philadelphia, PA: Elsevier-Mosby; 2004.
114. Centers for Disease Control and Prevention. Dietary guidelines for alcohol. Apr 2022 [internet publication].[Full Text]
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