isoflurane inhaled

Adult Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia induction

[individualize dose]

Info: titrate inhalation to effect; 1.5-3% produces surgical anesthesia x7-10min; blood/gas partition coefficient (37C) = 1.4

general anesthesia maintenance

[MAC in 100% oxygen]

Dose: individualize dose, typical range 1.5-3.5%; Info: titrate inhalation to effect; MAC in 19-30 yo = 1.28%, in 31-55 yo = 1.15%, in 55-83 yo = 1.05%; blood/gas partition coefficient (37C) = 1.4

[MAC in 70% nitrous oxide/30% oxygen]

Dose: individualize dose, typical range 1-2.5%; Info: titrate inhalation to effect; MAC in 19-30 yo = 0.56%, in 31-55 yo = 0.5%, in 55-83 yo = 0.37%; blood/gas partition coefficient (37C) = 1.4

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  VOLATILE LIQUID

general anesthesia induction

[individualize dose]

Info: titrate inhalation to effect; 1.5-3% produces surgical anesthesia x7-10min; blood/gas partition coefficient (37C) = 1.4

general anesthesia maintenance

[MAC in 100% oxygen]

Dose: individualize dose, typical range 1.5-3.5%; Info: titrate inhalation to effect; MAC in neonate <32 wk gestation = 1.28%, in neonate 32-37 wk gestation = 1.41%, in 0-1 mo = 1.6%, in 1-6 mo = 1.87%, in 6-12 mo = 1.8%, in 1-5 yo = 1.6%, in 6-10 yo = 1.45%, in 11-18 yo = 1.38%; blood/gas partition coefficient (37C) = 1.4

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised