Select a medication above to begin.
clomipramine
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: CAP: 25 mg, 50 mg, 75 mg
obsessive-compulsive disorder
- [150-250 mg PO qhs]
- Start: 25 mg PO qd, incr. by 25 mg/day q4-7 days; Max: 100 mg/day in first 2wk, 250 mg/day for maint. tx; Info: give in divided doses w/ food during initial titration; taper dose gradually to D/C
cataplexy (off-label)
- [25-75 mg PO qhs]
- Start: 25 mg PO qd, may incr. by 25 mg/day q4-7 days; Info: taper dose gradually to D/C
confusional arousals (off-label)
- [25-100 mg PO qhs]
- Start: 25 mg PO qhs, may incr. by 25 mg/day q4-7 days; Info: taper dose gradually to D/C
sleep terrors (off-label)
- [25-100 mg PO qhs]
- Start: 25 mg PO qhs, may incr. by 25 mg/day q4-7 days; Info: taper dose gradually to D/C
sleepwalking (off-label)
- [25-100 mg PO qhs]
- Start: 25 mg PO qhs, may incr. by 25 mg/day q4-7 days; Info: taper dose gradually to D/C
renal dosing
- [see below]
- mild-mod renal impairment: not defined; severe impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 25 mg, 50 mg, 75 mg
obsessive-compulsive disorder
- [10 yo and older]
- Dose: 100-200 mg PO qhs; Start: 25 mg PO qd, incr. by 25 mg/day q4-7 days; Max: 3 mg/kg/day up to 100 mg/day in first 2wk and up to 200 mg/day maint. tx; Info: give in divided doses w/ food during initial titration; taper dose gradually to D/C
cataplexy (off-label)
- [5 yo and older]
- Dose: 25-75 mg PO qhs; Start: 25 mg PO qd, may incr. by 25 mg/day q7 days; Max: 3 mg/kg/day up to 100 mg/day; Info: taper dose gradually to D/C
renal dosing
- [see below]
- mild-mod renal impairment: not defined; severe impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised