metolazone

Adult Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 10 mg

edema, heart failure-associated

[5-20 mg PO qd]

Start: 2.5 mg PO qd; Max: 20 mg/day

edema, renal dz-associated

[5-20 mg PO qd]

HTN

[2.5-5 mg PO qd]

renal dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised; anuria: contraindicated

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic coma or pre-coma: contraindicated

Peds Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 10 mg

edema, heart failure-associated (off-label)

[0.2-0.4 mg/kg/day PO divided q12-24h]

edema, renal dz-associated (off-label)

[0.2-0.4 mg/kg/day PO divided q12-24h]

renal dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised; anuria: contraindicated

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic coma or pre-coma: contraindicated