Select a medication above to begin.
Indocin Rectal
indomethacin rectal
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: SUPP: 50 mg
osteoarthritis, moderate-severe
- [25 mg PR bid-tid]
- Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk; use lowest effective dose, shortest effective tx duration
gout, acute
- [50 mg PR tid]
- Info: use lowest effective dose, shortest effective tx duration
bursitis/tendinitis, acute
- [75-150 mg/day PR divided tid-qid x7-14 days]
- Info: use lowest effective dose, shortest effective tx duration
ankylosing spondylitis, moderate-severe
- [25 mg PR bid-tid]
- Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk; use lowest effective dose, shortest effective tx duration
rheumatoid arthritis, moderate-severe
- [25 mg PR bid-tid]
- Max: 100 mg/dose, 200 mg/day; Info: may incr. dose by 25-50 mg/day qwk or by 25-50 mg/day qd if acute flare; use lowest effective dose, shortest effective tx duration
pancreatitis prevention, post-endoscopic retrograde cholangiopancreatography (off-label)
- [100 mg PR x1]
- Info: give immediately before or after procedure
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SUPP: 50 mg
juvenile idiopathic arthritis
- [2-14 yo (off-label)]
- Dose: 1-2 mg/kg/day PR divided bid-qid; Max: 4 mg/kg/day up to 200 mg/day; Info: use lowest effective dose, shortest effective tx duration
- [15 yo and older]
- Dose: 1-2 mg/kg/day PR divided bid-qid; Max: 4 mg/kg/day up to 200 mg/day; Info: use lowest effective dose, shortest effective tx duration
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [not defined]