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Naprelan
naproxen sodium
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: ER TAB: 375 mg, 500 mg, 750 mg
Special Note
- [strength clarification]
- Info: doses expressed as naproxen equivalents
osteoarthritis
- [750-1000 mg PO qd]
- Max: 1500 mg/day for <6mo; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [750-1000 mg PO qd]
- Max: 1500 mg/day for <6mo; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
ankylosing spondylitis
- [750-1000 mg PO qd]
- Max: 1500 mg/day for <6mo; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
gout, acute
- [1000 mg PO qd]
- Start: 1000-1500 mg PO qd x1; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
pain, mild-moderate
- [1000 mg PO qd]
- Max: 1500 mg/day for limited periods; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; also avail. as 10-day Dose Card of 1500 mg PO qd x3 days, then 1000 mg PO qd x7 days
dysmenorrhea
- [1000 mg PO qd]
- Max: 1500 mg/day for limited periods; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; also avail. as 10-day Dose Card of 1500 mg PO qd x3 days, then 1000 mg PO qd x7 days
for anti-inflammatory uses
- [1000 mg PO qd]
- Max: 1500 mg/day for limited periods; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs; also avail. as 10-day Dose Card of 1500 mg PO qd x3 days, then 1000 mg PO qd x7 days
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.