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phenelzine
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 15 mg
depression
- [15 mg PO qod-30 mg PO tid]
- Start: 15 mg PO tid, then incr. rapidly to 60-90 mg/day PO in divided doses and continue until clinical response, then decr. slowly over several wk to lowest effective dose; Max: 90 mg/day; Info: decr. start dose and titrate w/ caution in elderly pts; taper dose gradually to D/C
bulimia (off-label)
- [15 mg PO tid]
- Start: 15 mg PO tid, titrate to effect; Max: 90 mg/day; Info: taper dose gradually to D/C
renal dosing
- [see below]
- severe impairment: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic dz hx/elevated LFTs: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.