Jemperli (dostarlimab-gxly)

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = dostarlimab-gxly

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

endometrial CA

[primary advanced or recurrent dz]

Dose: 500 mg IV q3wk x6 doses as part of multi-drug chemo regimen, then 1000 mg IV q6wk as monotherapy for up to 3y

[mismatch repair deficient, recurrent or advanced dz]

Dose: 500 mg IV q3wk x4 doses, then 1000 mg IV q6wk; Info: for pts w/ dz progression on or after platinum-containing chemo not eligible for curative surgery or XRT

mismatch repair deficient solid tumors, recurrent or advanced

[500 mg IV q3wk x4 doses, then 1000 mg IV q6wk]

Info: for pts w/ progressive dz and no alternative tx options

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.