fluorouracil

Adult Dosing .

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

breast CA

[500 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle]

Alt: 600 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle; Info: give x6 cycles; part of multi-drug chemo regimen

colorectal CA

[bolus regimen]

Dose: 500 mg/m^2/dose IV x1 on days 1, 8, 15, 22, 29, 36 of 56-day cycle; Info: give x4 cycles; use w/ (levo)leucovorin

[infusional regimen]

Dose: 400 mg/m^2/dose IV x1 on day 1, then 1200-1500 mg/m^2/24h IV infusion on days 1, 2 of 14-day cycle; Info: use w/ (levo)leucovorin w/ or w/o irinotecan or oxaliplatin

gastric CA

[resectable dz]

Dose: 200 mg/m^2/24h IV infusion on days 1-21 of 21-day cycle; Alt: 800 mg/m^2/24h IV infusion on days 1-5 of 28-day cycle; Info: give x3 cycles preop, then x3 cycles postop; use w/ cisplatin or part of multi-drug chemo regimen

[advanced dz]

Dose: 750-1000 mg/m^2/24h IV infusion on days 1-4 of 28-day cycle; Info: use w/ cisplatin

pancreatic CA

[400 mg/m^2/dose IV x1 on day 1, then 1200 mg/m^2/24h IV infusion on days 1, 2 of 14-day cycle]

Info: give x12 cycles; part of multi-drug chemo regimen

renal dosing

[see below]

renal impairment: no adjustment

HD: decr. usual dose by up to 50%, on dialysis days admin. after dialysis; no supplement; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.