Neurontin

Adult Dosing .

Dosage forms:  CAP: 100 mg, 300 mg, 400 mg; TAB: 600 mg, 800 mg; SOL: 50 mg per mL

partial seizures

[300-1200 mg PO tid]

Start: 300 mg PO tid; Max: 3600 mg/day; Info: taper dose over >7 days to D/C

post-herpetic neuralgia

[300-600 mg PO tid]

Start: 300 mg PO qd x1 day, then 300 mg PO bid x1 day, then 300 mg PO tid; Max: 1800 mg/day; Info: taper dose over >7 days to D/C

neuropathic pain (off-label)

[300-1200 mg PO tid]

Start: 300 mg PO qd x1 day, then 300 mg PO bid x1 day, then 300 mg PO tid; Max: 3600 mg/day; Info: taper dose over >7 days to D/C

fibromyalgia (off-label)

[400-800 mg PO tid]

Start: 300 mg PO qd x1 day, then 300 mg PO bid x1 day, then 300 mg PO tid, then titrate to effect; Max: 2400 mg/day; Info: taper dose over >7 days to D/C

alcohol dependence (off-label)

[300-600 mg PO tid]

Start: 300 mg PO qd x1 day, then 300 mg PO bid x1 day, then 300 mg PO tid; Max: 1800 mg/day; Info: taper dose over >7 days to D/C

vasomotor sx, mod-severe menopausal (off-label)

[300-800 mg PO tid]

Start: 300 mg PO qhs x1 day, then 300 mg PO bid x1 day, then 300 mg PO tid, then titrate to effect; Max: 2400 mg/day; Info: start 100 mg PO qhs if sensitivity concern; taper dose over >7 days to D/C

essential tremor (off-label)

[600 mg PO tid]

Start: 300 mg PO tid; Max: 3600 mg/day; Info: taper dose over >7 days to D/C

renal dosing

[adjust dose amount, frequency]

CrCl 30-59: 200-700 mg bid; CrCl 16-29: 200-700 mg qd; CrCl 15: 100-300 mg qd; CrCl <15: decr. dose proportionately from CrCl 15

HD: decr. dose proportionately from CrCl 15; give 125-350 mg as supplement after dialysis; PD: 300 mg q48h; supplement not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  CAP: 100 mg, 300 mg, 400 mg; TAB: 600 mg, 800 mg; SOL: 50 mg per mL

partial seizures

[3-4 yo]

Dose: 40 mg/kg/day PO divided tid; Start: 10-15 mg/kg/day PO divided tid, titrate up over 3 days; Max: 50 mg/kg/day; Info: taper dose over >7 days to D/C

[5-11 yo]

Dose: 25-35 mg/kg/day PO divided tid; Start: 10-15 mg/kg/day PO divided tid, titrate up over 3 days; Max: 50 mg/kg/day; Info: taper dose over >7 days to D/C

[12 yo and older]

Dose: 300-800 mg PO tid; Start: 300 mg PO tid; Max: 3600 mg/day; Info: taper dose over >7 days to D/C

renal dosing

[adjust dose amount, frequency]

CrCl 30-50: give 75% usual dose bid; CrCl 15-29: give 75% usual dose qd; CrCl <15: give 75% usual dose qod

HD: give 75% usual dose qod; supplement after dialysis not defined; PD: give 75% usual dose qod; supplement not defined

hepatic dosing

[no adjustment]