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Myfembree
relugolix/ estradiol/ norethindrone acetate
Black Box Warnings .
Thromboembolic Disorders and Vascular Events
estrogen + progestin tx incr. thrombotic/thromboembolism risk incl. PE, DVT, stroke, and MI, esp. women at high risk for these events; contraindicated in women w/ current or past hx of thrombotic/thromboembolic disorder or if incr. risk, incl. smokers >35 yo and uncontrolled HTN
Adult Dosing .
Dosage forms: TAB: 40 mg/1 mg/0.5 mg
heavy menstrual bleeding, uterine fibroid-associated
- [1 tab PO qd]
- Start: after pregnancy excluded and w/in 7 days from onset of menses; Max: 24mo; Info: for premenopausal pts; D/C at least 4-6wk before major surgery if VTE risk
endometriosis-associated pain, moderate-severe
- [1 tab PO qd]
- Start: after pregnancy excluded and w/in 7 days from onset of menses; Max: 24mo; Info: for premenopausal pts; D/C at least 4-6wk before major surgery if VTE risk
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15 or ESRD: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment/dz: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.