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Wegovy
semaglutide
Black Box Warnings .
Thyroid C-cell Tumor Risk
contraindicated in pts w/ medullary thyroid carcinoma (MTC) hx or family hx, or in pts w/ multiple endocrine neoplasia syndrome type 2 (MEN 2); dose-related and duration-dependent incr. in thyroid C-cell tumor incidence observed in rodents, but human relevance unknown; uncertain value of routine serum calcitonin or thyroid ultrasound monitoring; advise pts of potential MTC risk and thyroid tumor sx (e.g., neck mass, dysphagia, dyspnea, persistent hoarseness)
Adult Dosing .
Dosage forms: INJ (pen): 0.25 mg per injection, 0.5 mg per injection, 1 mg per injection, 1.7 mg per injection, 2.4 mg per injection
weight management, chronic
- [1.7-2.4 mg SC qwk]
- Start: 0.25 mg SC qwk x4wk, then 0.5 mg SC qwk x4wk, then 1 mg SC qwk x4wk, then 1.7 mg SC qwk x4wk, then may incr. to 2.4 mg SC qwk; Info: for obese pts or overweight pts w/ wt-related comorbidity; may delay dose titration x4wk if intolerance
cardiovascular event risk reduction - overweight or obese pts w/ estab. cardiovascular dz
- [1.7-2.4 mg SC qwk]
- Start: 0.25 mg SC qwk x4wk, then 0.5 mg SC qwk x4wk, then 1 mg SC qwk x4wk, then 1.7 mg SC qwk x4wk, then may incr. to 2.4 mg SC qwk; Info: may delay dose titration x4wk if intolerance
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: INJ (pen): 0.25 mg per injection, 0.5 mg per injection, 1 mg per injection, 1.7 mg per injection, 2.4 mg per injection
weight management, chronic
- [12 yo and older]
- Dose: 1.7-2.4 mg SC qwk; Start: 0.25 mg SC qwk x4wk, then 0.5 mg SC qwk x4wk, then 1 mg SC qwk x4wk, then 1.7 mg SC qwk x4wk, then may incr. to 2.4 mg SC qwk; Info: for pts w/ obesity; may delay dose titration x4wk if intolerance
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]