Select a medication above to begin.
Tembexa
brincidofovir
Black Box Warnings .
Increased Mortality with Longer Duration
incr. mortality w/ brincidofovir vs. placebo in 24wk clinical trial when used in another dz
Adult Dosing .
Dosage forms: TAB: 100 mg; SUSP: 10 mg per mL
Restricted Distribution in US
- [distributed directly to CDC and US Dept. of Defense]
smallpox
- [>48 kg]
- Dose: 200 mg PO qwk x2 doses; Info: give tab on empty stomach or w/ low fat meal; give susp on empty stomach; do not cut/crush/chew tab; avoid direct contact w/ crushed or broken tab or susp
mpox (off-label)
- [>48 kg]
- Dose: 200 mg PO qwk x2 doses; Info: not 1st-line agent; give w/ tecovirimat; may extend duration based on clinical response; give tab on empty stomach or w/ low fat meal; give susp on empty stomach; do not cut/crush/chew tab; avoid direct contact w/ crushed or broken tab or susp
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 100 mg; SUSP: 10 mg per mL
Restricted Distribution in US
- [distributed directly to CDC and US Dept. of Defense]
smallpox
- [<10 kg]
- Dose: 6 mg/kg/dose susp PO qwk x2 doses; Info: give on empty stomach; avoid direct contact w/ susp
- [10-47 kg]
- Dose: 4 mg/kg/dose susp PO qwk x2 doses; Info: give on empty stomach; avoid direct contact w/ susp
- [>48 kg]
- Dose: 200 mg PO qwk x2 doses; Info: give tab on empty stomach or w/ low fat meal; give susp on empty stomach; do not cut/crush/chew tab; avoid direct contact w/ crushed or broken tab or susp
mpox (off-label)
- [<10 kg]
- Dose: 6 mg/kg/dose susp PO qwk x2 doses; Info: not 1st-line agent; give w/ tecovirimat; may extend duration based on clinical response; give on empty stomach; avoid direct contact w/ susp
- [10-47 kg]
- Dose: 4 mg/kg/dose susp PO qwk x2 doses; Info: not 1st-line agent; give w/ tecovirimat; may extend duration based on clinical response; give on empty stomach; avoid direct contact w/ susp
- [>48 kg]
- Dose: 200 mg PO qwk x2 doses; Info: not 1st-line agent; give w/ tecovirimat; may extend duration based on clinical response; give tab on empty stomach or w/ low fat meal; give susp on empty stomach; do not cut/crush/chew tab; avoid direct contact w/ crushed or broken tab or susp
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]