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Welireg
belzutifan
Black Box Warnings .
Embryo-Fetal Toxicity
exposure during pregnancy can cause embryo-fetal harm; verify pregnancy status prior to tx start; advise pts of risks and need for effective non-hormonal contraception; tx can render some hormonal contraceptives ineffective
Adult Dosing .
Dosage forms: TAB: 40 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
von Hippel-Lindau dz
- [120 mg PO qd]
- Info: for pts requiring tx but not requiring immediate surgery for associated renal cell carcinoma, CNS hemangioblastoma, or pancreatic neuroendocrine tumor; do not cut/crush/chew tab
renal cell CA, advanced
- [120 mg PO qd]
- Info: for pts who have received prior tx w/ PD-1/PD-L1 inhibitor and VEGF-TKI; do not cut/crush/chew tab
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.