Invega Hafyera

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 1092 mg per 3.5 mL, 1560 mg per 5 mL

schizophrenia

[conversion from paliperidone palmitate 156 mg/mo IM]

Dose: 1092 mg IM q6mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 1560 mg/dose; Info: may adjust dose q6mo; see pkg insert for missed dose recommendations; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[conversion from paliperidone palmitate 234 mg/mo IM]

Dose: 1560 mg IM q6mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 1560 mg/dose; Info: may adjust dose q6mo; see pkg insert for missed dose recommendations; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[conversion from paliperidone palmitate 546 mg IM q3mo]

Dose: 1092 mg IM q6mo; Start: at next scheduled dose; Max: 1560 mg/dose; Info: may adjust dose q6mo; see pkg insert for missed dose recommendations; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[conversion from paliperidone palmitate 819 mg IM q3mo]

Dose: 1560 mg IM q6mo; Start: at next scheduled dose; Max: 1560 mg/dose; Info: may adjust dose q6mo; see pkg insert for missed dose recommendations; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[see below]

CrCl 50-79: adjust dose using 1-mo IM paliperidone palmitate form prior to conversion; CrCl <50: avoid use

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.