Norpace

Adult Dosing .

Dosage forms:  CAP: 100 mg, 150 mg

ventricular arrhythmias

[<50 kg]

Dose: 100 mg PO q6h; Start: 200 mg PO x1; 100 mg PO q6-8h if cardiomyopathy or cardiac decompensation; Max: 1600 mg/day

[>50 kg]

Dose: 150 mg PO q6h; Start: 300 mg PO x1; 100 mg PO q6-8h if cardiomyopathy or cardiac decompensation; Max: 1600 mg/day; Alt: 200 mg PO q6h if no response/toxicity w/in 6h of loading dose

atrial fibrillation (off-label)

[100-400 mg PO bid-tid]

Max: 800 mg/day; Info: for maintenance rhythm control

renal dosing

[adjust dose amount, frequency]

CrCl 41-59: 100 mg q6h; CrCl 30-40: 100 mg q8h; CrCl 15-29: 100 mg q12h; CrCl <15: 100 mg q24h; Info: may give loading dose 150 mg x1 if CrCl <41

HD: 100 mg q24-48h; no supplement after dialysis; PD: 100 mg q24-48h; no supplement

hepatic dosing

[adjust dose amount]

hepatic impairment: 100 mg q6h

Peds Dosing .

Dosage forms:  CAP: 100 mg, 150 mg

ventricular arrhythmia (off-label)

[<1 yo]

Dose: 10-30 mg/kg/day PO divided q6h; Info: doses may require pharmacy compounding

[1-4 yo]

Dose: 10-20 mg/kg/day PO divided q6h; Info: doses may require pharmacy compounding

[4-12 yo]

Dose: 10-15 mg/kg/day PO divided q6h; Info: doses may require pharmacy compounding

[12-18 yo]

Dose: 6-15 mg/kg/day PO divided q6h; Info: doses may require pharmacy compounding

renal dosing

[adjust dose frequency]

CrCl 30-40: give usual dose q8h; CrCl 15-29: give usual dose q12h; CrCl <15: give usual dose q24h

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined