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Apretude
cabotegravir
Black Box Warnings .
Drug Resistance Risk in Undiagnosed HIV-1 Infection
test pts for HIV-1 infection prior to starting cabotegravir and w/ each subsequent injection; drug-resistant variants identified in pts w/ undiagnosed HIV-1 infection; do not start cabotegravir unless negative HIV-1 infection status confirmed; pts infected w/ HIV-1 must transition to a complete tx regimen
Adult Dosing .
Dosage forms: INJ
HIV pre-exposure prophylaxis
- [initiation injections]
- Dose: 600 mg IM qmo x2; Info: start w/in 3 days of last PO cabotegravir dose if oral lead-in used; may give 2nd injection up to 7 days before or after scheduled dose; check HIV status w/ HIV-1 RNA before tx start and w/ every injection or upon diagnosis of other sexually transmitted infections
- [continuation injections]
- Dose: 600 mg IM q2mo; Info: may give injections up to 7 days before or after scheduled dose; if planned missed dose by >7 days, give PO cabotegravir for up to 2mo; see pkg insert for unplanned missed dose recommendations; check HIV status w/ HIV-1 RNA before tx start and w/ every injection or upon diagnosis of other sexually transmitted infections
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: INJ
HIV pre-exposure prophylaxis
- [initial injections, adolescents >35 kg]
- Dose: 600 mg IM qmo x2; Info: start w/in 3 days of last PO cabotegravir dose if oral lead-in used; may give 2nd injection up to 7 days before or after scheduled dose; check HIV status w/ HIV-1 RNA before tx start and w/ every injection or upon diagnosis of other sexually transmitted infections
- [continuation injections, adolescents >35 kg]
- Dose: 600 mg IM q2mo; Info: may give injections up to 7 days before or after scheduled dose; if planned missed dose by >7 days, give PO cabotegravir for up to 2mo; see pkg insert for unplanned missed dose recommendations; check HIV status w/ HIV-1 RNA before tx start and w/ every injection or upon diagnosis of other sexually transmitted infections
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined