magnesium sulfate

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: MgSO4 contains approx. 9.86% elemental Mg; 1 g MgSO4 = 98.6 mg (8.12 mEq) elemental Mg; doses expressed as MgSO4

hypomagnesemia, symptomatic

[hemodynamically stable]

Dose: 4-8 g IV over 12-24h prn; Start: 1-2 g IV over 5-60min x1; Info: adjust dose based on serum magnesium levels

[hemodynamically unstable]

Dose: 1-2 g IV over 2-15min x1; Info: may follow w/ 3-20 mg/min IV

hypomagnesemia, asymptomatic

[plasma Mg <1 mg/dL]

Dose: 4-8 g IV over 12-24h; Alt: up to 250 mg/kg/dose IM w/in 4h; Info: adjust dose based on serum magnesium levels

[plasma Mg 1-1.5 mg/dL]

Dose: 2-4 g IV over 4-12h; Info: adjust dose based on serum magnesium levels

[plasma Mg 1.6-1.9 mg/dL]

Dose: 1-2 g IV over 1-2h; Alt: 1 g IM q6h x4 doses; Info: adjust dose based on serum magnesium levels

seizures, preeclampsia or eclampsia-assoc.

[1-2 g/h IV for at least 24h]

Start: 4-6 g IV x1; Max: 40 g/24h; x5-7 days; Alt: if no IV access, give 5 g IM x1 to each buttock, then 5 g IM to alternate buttocks q4h prn

tocolysis (off-label)

[2-4 g/h IV x12-24h]

Start: 4-6 g IV x1; Max: x5-7 days

ventricular arrhythmia (off-label)

[3-20 mg/min IV x5-48h]

Start: 2-6 g IV x1

torsades de pointes (off-label)

[w/o cardiac arrest]

Dose: 1-2 g IV over 15min x1; Info: may follow w/ 3-20 mg/min IV

[w/ cardiac arrest]

Dose: 1-2 g IV over 1-2min x1; Info: may follow w/ 3-20 mg/min IV

severe asthma exacerbation, adjunct tx (off-label)

[2 g IV x1]

renal dosing

[seizures, preeclampsia or eclampsia-assoc.]

severe impairment: max 20 g/48h

HD/PD: not defined

[all other indications]

severe impairment: decr. usual dose, amount not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: MgSO4 contains approx. 9.86% elemental Mg; 1 g MgSO4 = 98.6 mg (8.12 mEq) elemental Mg; doses expressed as MgSO4

hypomagnesemia, symptomatic (off-label)

[neonates]

Dose: 25-50 mg/kg/dose IV q8-12h x2-3 doses; Max: 2 g/dose; Info: adjust dose based on serum magnesium levels

[infants/children]

Dose: 25-50 mg/kg/dose IV q6h x3-4 doses; Max: 2 g/dose; Info: adjust dose based on serum magnesium levels

ventricular arrhythmias, post-cardiopulmonary bypass (off-label)

[25-50 mg/kg/dose IV x1]

Max: 2 g/dose; Info: for prevention and tx

torsades de pointes (off-label)

[25-50 mg/kg/dose IV/IO x1 prn]

Max: 2 g/dose

severe asthma exacerbation, adjunct tx (off-label)

[2-5 yo]

Dose: 40-50 mg/kg/dose IV x1; Max: 2g/dose

[>5 yo]

Dose: 40-50 mg/kg/dose IV x1; Max: 2g/dose

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]