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Parnate
tranylcypromine
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Hypertensive Crisis Risk
excessive consumption of foods or beverages w/ significant tyramine content or use of certain drugs during or after tranylcypromine D/C may precipitate hypertensive crisis; monitor BP and allow for drug-free intervals between tranylcypromine and interacting drugs; avoid foods and beverages containing high tyramine content
Adult Dosing .
Dosage forms: TAB: 10 mg
depression
- [10 mg PO tid]
- Start: 10 mg PO tid x2wk, may incr. by 10 mg/day q1-3wk; Max: 60 mg/day; Info: taper dose gradually to D/C
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic dz hx/elevated LFTs: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.