penicillin V potassium

Adult Dosing .

Dosage forms:  TAB: 250 mg, 500 mg; SUSP: 125 mg per 5 mL, 250 mg per 5 mL

Special Note

[strength clarification]

Info: 250 mg PCN VK = 400,000 units PCN

infections, bacterial

[125-500 mg PO q6-8h]

Info: dose, duration vary by infection type/severity; give 1h before or 2h after meals

pharyngitis, streptococcal

[500 mg PO bid x10 days]

Alt: 250 mg PO qid x10 days; Info: give 1h before or 2h after meals

rheumatic fever prophylaxis, secondary

[250 mg PO bid]

Info: give 1h before or 2h after meals

anthrax (off-label)

[cutaneous]

Dose: 500 mg PO q6h x7-10 days; Info: for non-systemic infection w/ penicillin-susceptible B. anthracis; not 1st-line agent; use extended duration for post-exposure prophylaxis if bioterrorism suspected; give 1h before or 2h after meals

[post-exposure prophylaxis]

Dose: 500 mg PO q6h x60 days; Info: for penicillin-susceptible B. anthracis; not 1st-line agent; give in combo w/ anthrax vaccine; may use to complete course for systemic infection; give 1h before or 2h after meals; may give x42 days or x14 days after last vaccine dose in immunocompetent pts 18-65 yo if anthrax vaccine regimen completed

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 250 mg, 500 mg; SUSP: 125 mg per 5 mL, 250 mg per 5 mL

Special Note

[strength clarification]

Info: 250 mg PCN VK = 400,000 units PCN

infections, bacterial

[25-75 mg/kg/day PO divided q6-8h]

Max: 3000 mg/day; Info: dose, duration vary by infection type/severity; give 1h before or 2h after meals

pharyngitis, streptococcal

[children, <27 kg]

Dose: 250 mg PO bid-tid x10 days; Info: give 1h before or 2h after meals

[children, >27 kg]

Dose: 500 mg PO bid x10 days; Info: give 1h before or 2h after meals

[adolescents]

Dose: 500 mg PO bid x10 days; Alt: 250 mg PO qid x10 days; Info: give 1h before or 2h after meals

rheumatic fever prophylaxis, secondary

[children]

Dose: 250 mg PO bid; Info: give 1h before or 2h after meals

anthrax, cutaneous (off-label)

[neonates >32 wk gestation]

Dose: 50-75 mg/kg/day PO divided q6-12h x7-10 days; Info: for penicillin-susceptible B. anthracis non-systemic infection; not 1st-line agent; dose, frequency depend on gestational and post-natal age; give abx x60 days total if bioterrorism suspected; give 1h before or 2h after meals

[1 mo and older]

Dose: 50-75 mg/kg/day PO divided q6-8h x7-10 days; Info: for penicillin-susceptible B. anthracis non-systemic infection; not 1st-line agent; give abx x60 days total if bioterrorism suspected; give 1h before or 2h after meals

anthrax, post-exposure prophylaxis (off-label)

[neonates >32 wk gestation]

Dose: 50-75 mg/kg/day PO divided q6-12h x60 days; Info: for penicillin-susceptible B. anthracis exposure; not 1st-line agent; may use to complete course for systemic infection; dose, frequency depend on gestational and post-natal age; give 1h before or 2h after meals

[1 mo and older]

Dose: 50-75 mg/kg/day PO divided q6-8h x60 days; Info: for penicillin-susceptible B. anthracis exposure; not 1st-line agent; may use to complete course for systemic infection; give 1h before or 2h after meals

community-acquired pneumonia, bacterial (off-label)

[>3 mo]

Dose: 50-75 mg/kg/day PO divided q6-8h x7-10 days; Info: give 1h before or 2h after meals

pneumococcal infection prophylaxis, sickle cell dz pts (off-label)

[<3 yo]

Dose: 125 mg PO bid; Info: give 1h before or 2h after meals

[3-5 yo]

Dose: 250 mg PO bid; Info: give 1h before or 2h after meals

renal dosing

[if usual regimen q6-8h]

CrCl <10: give usual divided dose q8h

HD: give usual divided dose q8h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose q8h; no supplement

[all other regimens]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]