Hylenex Recombinant

Adult Dosing .

Dosage forms:  INJ

hypodermoclysis, adjunct tx

[150 units SC X1, given before clysis hydration of 1000 mL or more]

Alt: 150 units added to clysis hydration up to 200 mL, given via SC infusion x1; Info: rate and volume of clysis should not exceed those for IV infusion

absorption and dispersion of injected drugs, adjunct tx

[150 units added to injection solution, given SC x1]

Alt: 150 units SC x1, given before admin. of injected drug; Info: dose range 50-300 units

SC urography, adjunct tx

[75 units SC x1 over each scapula, followed by contrast medium at same site]

Info: for pts unable to receive IV urographic contrast media; pts should be in prone position

extravasation tx, chemo-associated (off-label)

[150-900 units SC x1 divided into clockwise injections around extravasation site]

Alt: 150-900 units IV x1 via existing IV line; Info: usual dose is 150 units (1 mL) for each 1 mL of extravasated docetaxel, paclitaxel, or vinca alkaloids

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

hypodermoclysis, adjunct tx

[150 units SC X1, given before clysis hydration of 1000 mL or more]

Alt: 150 units added to clysis hydration up to 200 mL, given via SC infusion x1; Info: for infants and children <3 yo, each clysis hydration should not exceed 200 mL; for premature infants and neonates, daily clysis hydration should not exceed 25 mL/kg and admin. rate should not exceed 2 mL/min; for older pts, rate and volume of clysis should not exceed those for IV infusion

absorption and dispersion of injected drugs, adjunct tx

[150 units added to injection solution, given SC x1]

Alt: 150 units SC x1, given before admin. of injected drug; Info: dose range 50-300 units

SC urography, adjunct tx

[75 units SC x1 over each scapula, followed by contrast medium at same site]

Info: for pts unable to receive IV urographic contrast media, esp. in infants and small children; pts should be in prone position

extravasation tx, chemo-associated (off-label)

[150-900 units SC x1 divided into clockwise injections around extravasation site]

Alt: 150-900 units IV x1 via existing IV line; Info: usual dose is 150 units (1 mL) for each 1 mL of extravasated docetaxel, paclitaxel, or vinca alkaloids

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]