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Auvelity
dextromethorphan/ bupropion hydrochloride
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds pts
Adult Dosing .
Dosage forms: ER TAB: 45 mg/105 mg
major depressive disorder
- [1 tab PO bid]
- Start: 1 tab PO qam, incr. to 1 tab PO bid after 3 days; Max: 2 tabs/day; Info: give 1 tab PO qam in poor CYP2D6 metabolizers; separate doses by at least 8h; do not cut/crush/chew tab
renal dosing
- [see below]
- eGFR 30-59: 1 tab qam; eGFR <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.