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Ablysinol
dehydrated alcohol (ethanol)
Adult Dosing .
Dosage forms: INJ: 99%
septal myocardial ablation, obstructive hypertrophic cardiomyopathy pts
- [1-3 mL/procedure (99%) intra-arterially divided in multiple sites]
- Max: 5 mL/procedure; Info: inject in septal artery branches via percutaneous catheter; use lowest effective dose
ethylene glycol toxicity (off-label)
- [non-drinker]
- Dose: 0.83 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until ethylene glycol level <20 mg/dL and pt asymptomatic w/ normal pH
- [chronic drinker]
- Dose: 1.96 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until ethylene glycol level <20 mg/dL and pt asymptomatic w/ normal pH
methanol toxicity (off-label)
- [non-drinker]
- Dose: 0.83 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until methanol level <20 mg/dL and pt asymptomatic w/ normal pH
- [chronic drinker]
- Dose: 1.96 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until methanol level <20 mg/dL and pt asymptomatic w/ normal pH
renal dosing
- [septal ablation]
- renal impairment: not defined
- HD/PD: not defined
- [ethylene glycol or methanol toxicity, non-drinker]
- renal impairment: not defined; Info: caution advised if significant impairment
- HD: incr. usual dose to 2.13 mL/kg/h (10%); no supplement after dialysis; PD: not defined
- [ethylene glycol or methanol toxicity, chronic drinker]
- renal impairment: not defined; Info: caution advised if significant impairment
- HD: incr. usual dose to 3.26 mL/kg/h (10%); no supplement after dialysis; PD: not defined
hepatic dosing
- [septal ablation]
- hepatic impairment: not defined
- [ethylene glycol or methanol toxicity]
- hepatic dz or impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ: 99%
ethylene glycol toxicity (off-label)
- [non-drinker]
- Dose: 0.83 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until ethylene glycol level <20 mg/dL and pt asymptomatic w/ normal pH
- [chronic drinker]
- Dose: 1.96 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until ethylene glycol level <20 mg/dL and pt asymptomatic w/ normal pH
methanol toxicity (off-label)
- [non-drinker]
- Dose: 0.83 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until methanol level <20 mg/dL and pt asymptomatic w/ normal pH
- [chronic drinker]
- Dose: 1.96 mL/kg/h (10%) IV; Start: 7.6 mL/kg/dose (10%) IV x1 if serum ethanol level zero or decr. if ethanol present; Info: dilute 99% solution w/ D5W to 10% conc. prior to use; cont. until methanol level <20 mg/dL and pt asymptomatic w/ normal pH
renal dosing
- [ethylene glycol or methanol toxicity, non-drinker]
- renal impairment: not defined; Info: caution advised if significant impairment
- HD: incr. usual dose to 2.13 mL/kg/h (10%); no supplement after dialysis; PD: not defined
- [ethylene glycol or methanol toxicity, chronic drinker]
- renal impairment: not defined; Info: caution advised if significant impairment
- HD: incr. usual dose to 3.26 mL/kg/h (10%); no supplement after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic dz or impairment: not defined, caution advised