famotidine

Adult Dosing .

Dosage forms:  TAB: 10 mg, 20 mg, 40 mg; SUSP: 40 mg per 5 mL; INJ: various

duodenal ulcer, active

[40 mg PO qhs for up to 8wk]

Alt: 20 mg PO bid for up to 8wk or 20 mg IV q12h; Info: if unable to take PO may use IV short-term only

duodenal ulcer, maintenance tx

[20 mg PO qhs]

gastric ulcer, active

[40 mg PO qhs for up to 8wk]

Alt: 20 mg IV q12h; Info: if unable to take PO may use IV short-term only

GERD

[non-erosive, symptomatic]

Dose: 20 mg PO bid for up to 6wk

[erosive esophagitis]

Dose: 20-40 mg PO bid for up to 12wk; Alt: 20 mg IV q12h; Info: if unable to take PO may use IV short-term only

hypersecretory conditions

[20-60 mg PO q6h]

Start: 20 mg PO q6h; Max: 160 mg PO q6h; Alt: 20 mg IV q12h

intractable ulcer

[20 mg IV q12h]

renal dosing

[PO route, active duodenal or gastric ulcer]

CrCl 30-60: max 20 mg PO qd or 40 mg PO qod; CrCl <30: max 10 mg PO qd or 20 mg PO qod

HD: 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; PD: 10 mg PO qd or 20 mg PO qod; no supplement

[PO route, duodenal ulcer maintenance tx]

CrCl 30-60: max 10 mg PO qd or 20 mg PO qod; CrCl <30: max 10 mg PO qod

HD: 10 mg PO qod, on dialysis days admin. after dialysis; no supplement; PD: 10 mg PO qod; no supplement

[PO route, non-erosive symptomatic GERD]

CrCl 30-60: max 20 mg PO qd; CrCl <30: max 10 mg PO qd or 20 mg PO qod

HD: 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; PD: 10 mg PO qd or 20 mg PO qod; no supplement

[PO route, GERD-assoc. erosive esophagitis]

CrCl 30-60: if usual dose 40 mg/day give max 20 mg PO qd or 40 mg PO qod; if usual dose 80 mg/day give max 40 mg PO qd; CrCl <30: if usual dose 40 mg/day give max 10 mg PO qd or 20 mg PO qod; if usual dose 80 mg/day give max 20 mg PO qd

HD: if usual dose 40 mg/day give 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; if usual dose 80 mg/day, not defined; PD: if usual dose 40 mg/day give 10 mg PO qd or 20 mg PO qod; no supplement; if usual dose 80 mg/day, not defined

[PO route, hypersecretory conditions]

CrCl <60: avoid use

HD/PD: not defined

[IV route]

CrCl 10-50: 10 mg IV q12h; CrCl <10: 10 mg IV q24h

HD: 10 mg IV q24h, on dialysis days admin. after dialysis; no supplement; PD: 10 mg IV q24h; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 10 mg, 20 mg, 40 mg; SUSP: 40 mg per 5 mL; INJ: various

PUD

[suspension form, 1-16 yo]

Dose: 0.5-1 mg/kg/day PO divided qd-bid for up to 8wk; Start: 0.5 mg/kg/day PO divided qd-bid; Max: 40 mg/day

[active duodenal ulcer, tablet form, >40 kg]

Dose: 40 mg PO qhs for up to 8wk; Alt: 20 mg PO bid for up to 8wk

[active gastric ulcer, tablet form, >40 kg]

Dose: 40 mg PO qhs for up to 8wk

[IV form, 1-16 yo]

Dose: 0.5-1 mg/kg/day IV divided q12h; Max: 40 mg/day; Info: if unable to take PO may use IV short-term only

GERD

[suspension form, <3 mo]

Dose: 0.5-1 mg/kg/dose PO qhs x4-8wk; Start: 0.5 mg/kg/dose PO qhs

[suspension form, 3-11 mo]

Dose: 1-2 mg/kg/day PO divided bid x4-8wk; Start: 1 mg/kg/day PO divided bid; Max: 40 mg/day

GERD, non-erosive symptomatic

[tablet form, >40 kg]

Dose: 20 mg PO bid for up to 6wk

[suspension form, 1-16 yo]

Dose: 1 mg/kg/day PO divided bid for up to 6wk; Max: 40 mg bid

[IV form, 1-16 yo]

Dose: 0.5 mg/kg/day IV divided q12h; Max: 40 mg/day; Info: if unable to take PO may use IV short-term only

GERD, erosive esophagitis

[tablet form, >40 kg]

Dose: 20-40 mg PO bid for up to 12wk

[suspension form, 1-16 yo]

Dose: 1 mg/kg/day PO divided bid for up to 12wk; Max: 40 mg bid

[IV form, 1-16 yo]

Dose: 0.5 mg/kg/day IV divided q12h; Max: 40 mg/day; Info: if unable to take PO may use IV short-term only

renal dosing

[suspension or IV form]

CrCl 30-50: give usual divided dose q24h; CrCl 10-29: give 50% usual divided dose q24h; CrCl <10: give 25% usual divided dose q24h

HD: give 25% usual divided dose q24h, on dialysis days admin. after dialysis; no supplement; PD: give 25% usual divided dose q24h; no supplement

[>40 kg, tablet form, active duodenal or gastric ulcer]

CrCl 30-60: max 20 mg PO qd or 40 mg PO qod; CrCl <30: max 10 mg PO qd or 20 mg PO qod

HD: 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; PD: 10 mg PO qd or 20 mg PO qod; no supplement

[>40 kg, tablet form, non-erosive symptomatic GERD]

CrCl 30-60: max 20 mg PO qd; CrCl <30: max 10 mg PO qd or 20 mg PO qod

HD: 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; PD: 10 mg PO qd or 20 mg PO qod; no supplement

[>40 kg, tablet form, GERD-assoc. erosive esophagitis]

CrCl 30-60: if usual dose 40 mg/day give max 20 mg PO qd or 40 mg PO qod; if usual dose 80 mg/day give max 40 mg PO qd; CrCl <30: if usual dose 40 mg/day give max 10 mg PO qd or 20 mg PO qod; if usual dose 80 mg/day give max 20 mg PO qd

HD: if usual dose 40 mg/day give 10 mg PO qd or 20 mg PO 3x/wk, on dialysis days admin. after dialysis; no supplement; if usual dose 80 mg/day, not defined; PD: if usual dose 40 mg/day give 10 mg PO qd or 20 mg PO qod; no supplement; if usual dose 80 mg/day, not defined

hepatic dosing

[not defined]