bumetanide

Adult Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg; INJ: various

edema

[PO route]

Dose: 0.5-10 mg/day PO divided qd-bid; Start: 0.5-2 mg PO qd, repeat q4-5h until response obtained; Max: 10 mg/day; Info: for pts w/ CHF, hepatic dz or renal dz; maint. doses may be given intermittently

[IM/IV route]

Dose: 0.5-10 mg/day IM/IV divided qd-bid; Start: 0.5-1 mg IM/IV over 2min, repeat q2-3h until response obtained; Max: 10 mg/day; Info: for pts w/ CHF, hepatic dz or renal dz

hypercalcemia (off-label)

[1-2 mg IV q1-4h]

Info: give w/ saline to maintain urine output of 200-250 mL/h

HTN (off-label)

[0.5-2 mg/day PO divided qd-bid]

Start: 0.5 mg PO qd; Max: 4 mg/day

renal dosing

[see below]

anuria: contraindicated

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

cirrhosis/ascites: not defined, caution advised; hepatic coma: contraindicated

Peds Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg; INJ: various

edema (off-label)

[0-6 mo]

Dose: 0.01-0.05 mg/kg/dose PO/IM/IV q24-48h; Info: for pts w/ CHF

[>6 mo]

Dose: 0.015-0.1 mg/kg/dose PO/IM/IV q24-48h; Max: 10 mg/day; Info: for pts w/ CHF

renal dosing

[see below]

anuria: contraindicated

HD: not defined; PD: no adjustment; no supplement

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance