repaglinide

Adult Dosing .

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg

diabetes mellitus, type 2

[HbA1c <8% or tx-naive]

Dose: 0.5-4 mg PO 15-30min before each meal; Start: 0.5 mg PO 15-30min before each meal, may double preprandial dose no more frequently than qwk; Max: 4 mg/dose up to 16 mg/day; Info: skip dose if meal skipped

[HbA1c >8% or tx-experienced]

Dose: 0.5-4 mg PO 15-30min before each meal; Start: 1-2 mg PO 15-30min before each meal, may double preprandial dose no more frequently than qwk; Max: 4 mg/dose up to 16 mg/day; Info: skip dose if meal skipped

renal dosing

[adjust dose amount]

CrCl 20-40: start 0.5 mg before each meal, titrate slowly; CrCl <20: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; Info: wait longer intervals between dose adjustments

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.