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Abilify Asimtufii
aripiprazole bimonthly injection
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 720 mg per 2.4 mL, 960 mg per 3.2 mL
schizophrenia
- [conversion from PO antipsychotic, 1-day initiation regimen]
- Dose: 960 mg IM q2mo; Start: after establishing tolerability w/ PO aripiprazole; give 960 mg IM x1 plus aripiprazole 400 mg/mo IM x1 plus aripiprazole 20 mg PO x1; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, start 720 mg IM x1 plus aripiprazole 300 mg/mo IM x1 plus aripiprazole 20 mg PO x1, then 720 mg IM q2mo; restart initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from PO antipsychotic, 14-day initiation regimen]
- Dose: 960 mg IM q2mo; Start: after establishing tolerability w/ PO aripiprazole; overlap PO antipsychotic tx x14 days; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, give 720 mg IM q2mo; restart initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from 1-mo IM aripiprazole]
- Dose: 960 mg IM q2mo; Start: at next scheduled injection; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, give 720 mg IM q2mo; restart tx w/ 1-day or 14-day initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, maintenance tx
- [conversion from PO antipsychotic, 1-day initiation regimen]
- Dose: 960 mg IM q2mo; Start: after establishing tolerability w/ PO aripiprazole; give 960 mg IM x1 plus aripiprazole 400 mg/mo IM x1 plus aripiprazole 20 mg PO x1; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, start 720 mg IM x1 plus aripiprazole 300 mg/mo IM x1 plus aripiprazole 20 mg PO x1, then 720 mg IM q2mo; restart initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from PO antipsychotic, 14-day initiation regimen]
- Dose: 960 mg IM q2mo; Start: after establishing tolerability w/ PO aripiprazole; overlap PO antipsychotic tx x14 days; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, give 720 mg IM q2mo; restart initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from 1-mo IM aripiprazole]
- Dose: 960 mg IM q2mo; Start: at next scheduled injection; Info: may decr. dose to 720 mg IM q2mo; in CYP2D6 poor metabolizers, give 720 mg IM q2mo; restart tx w/ 1-day or 14-day initiation regimen if tx interrupted >14wk; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.