Select a medication above to begin.
Amtagvi
lifileucel
Black Box Warnings .
Treatment-Related Mortality
admin. in inpatient hospital setting; intensive care facility, specialists skilled in cardiopulmonary or intensive care medicine must be avail.
Prolonged Severe Cytopenia and Severe Infection
admin. G-CSF daily starting day 1 after tx until ANC >1000 x3 days or per institutional standard; treat severe infections; monitor pts for prolonged severe cytopenia, internal organ hemorrhage
Cardiopulmonary and Renal Impairment
monitor cardiopulmonary, renal fxn throughout tx course
Adult Dosing .
Dosage forms: INJ
Restricted Distribution in US
- [1-833-400-4682 or www.amtagvi.com for more info]
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, prophylactic meds, and dosing incl. toxicity-related dose adjustments
melanoma, unresectable or metastatic
- [7.5-72 x10^9 viable T-cells/dose IV x1]
- Start: 1-4 days after completing lymphodepleting combo chemo regimen cyclophosphamide + fludarabine; Info: for pts previously treated w/ PD-1 or BRAF inhibitor; admin. aldesleukin starting 3-24h after tx
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.