Truqap

Adult Dosing .

Dosage forms:  TAB: 160 mg, 200 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

hormone receptor-positive HER2-negative breast CA, locally advanced or metastatic

[400 mg PO bid on days 1-4 of 7-day cycle]

Info: for pts w/ PIK3CA/AKT1/PTEN alteration w/ dz progression on endocrine-based tx; use w/ fulvestrant; give w/ LHRH agonist in pre/perimenopausal female pts; consider giving w/ LHRH agonist in male pts; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.