Select a medication above to begin.
omeprazole
generic
Adult Dosing .
Dosage forms: DR CAP: 10 mg, 20 mg, 40 mg; DR TAB: 20 mg; DR ODT: 20 mg
GERD
- [non-erosive, symptomatic]
- Dose: 20 mg PO qd x4-8wk; Info: give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
- [erosive esophagitis, short-term tx]
- Dose: 20 mg PO qd x4-12wk; Info: give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
- [erosive esophagitis, maintenance tx]
- Dose: 20 mg PO qd; Info: decr. dose to 10 mg PO qd in Asian pts (incr. risk of CYP2C19 poor metabolizer); give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
gastric ulcer
- [40 mg PO qd x4-8wk]
- Info: give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
duodenal ulcer
- [20-40 mg PO qd x4-8wk]
- Info: maint. dose 20 mg/day; give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
hypersecretory conditions
- [individualize dose PO qd-tid]
- Start: 60 mg PO qd; Info: doses up to 120 mg PO tid have been used; divide doses >80 mg/day; give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
H. pylori infection
- [20-40 mg PO bid x14 days]
- Info: part of multi-drug regimen, dosing may vary; give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
gastric ulcer prophylaxis, NSAID-assoc. (off-label)
- [20-40 mg PO qd]
- Info: give before meals; may open cap, see PPI Administration Alternatives table; do not cut/crush/chew ODT form
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [erosive esophagitis, maintenance tx]
- hepatic impairment: 10 mg qd
- [all other indications]
- hepatic impairment: not defined
Peds Dosing .
- Dosage forms: DR CAP: 10 mg, 20 mg, 40 mg; DR TAB: 20 mg
GERD, non-erosive symptomatic
- [1-16 yo, 10-20 kg]
- Dose: 10 mg PO qd for up to 4wk; Alt: start 1 mg/kg/day PO divided qd-bid, then 0.2-3.5 mg/kg/day divided qd-bid; Info: give before meals; may open cap, see PPI Administration Alternatives table
- [1-16 yo, >20 kg]
- Dose: 20 mg PO qd for up to 4wk; Alt: start 1 mg/kg/day PO divided qd-bid, then 0.2-3.5 mg/kg/day divided qd-bid; Info: give before meals; may open cap, see PPI Administration Alternatives table
GERD, erosive esophagitis
- [1-11 mo, >10 kg]
- Dose: 10 mg PO qd for up to 6wk; Info: for short-term tx; give before meals; may open cap, see PPI Administration Alternatives table
- [1-16 yo, 10-20 kg]
- Dose: 10 mg PO qd; Alt: start 1 mg/kg/day PO divided qd-bid, then 0.2-3.5 mg/kg/day divided qd-bid; Info: for short-term and maintenance tx; consider decr. maint. dose in Asian pts (incr. risk of CYP2C19 poor metabolizer); give before meals; may open cap, see PPI Administration Alternatives table
- [1-16 yo, >20 kg]
- Dose: 20 mg PO qd; Alt: start 1 mg/kg/day PO divided qd-bid, then 0.2-3.5 mg/kg/day divided qd-bid; Info: for short-term and maintenance tx; consider decr. maint. dose in Asian pts (incr. risk of CYP2C19 poor metabolizer); give before meals; may open cap, see PPI Administration Alternatives table
H. pylori infection (off-label)
- [15-24 kg]
- Dose: 20 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
- [25-34 kg]
- Dose: 30 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
- [>35 kg]
- Dose: 40 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; may open cap, see PPI Administration Alternatives table; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [erosive esophagitis, maintenance tx]
- hepatic impairment: consider decr. usual dose
- [all other indications]
- hepatic impairment: not defined