Select a medication above to begin.
lisinopril
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg
HTN
- [10-40 mg PO qd]
- Start: 10 mg PO qd; Info: start 5 mg PO qd if also on diuretic
heart failure w/ reduced ejection fraction
- [20-40 mg PO qd]
- Start: 5 mg PO qd, may incr. dose q1-2wk; Max: 40 mg/day; Info: start 2.5 mg PO qd if Na <130 mEq/L
left ventricular dysfxn, post-MI
- [10 mg PO qd for at least 6wk]
- Start: 5 mg PO x1 w/in 24h of MI, then 5 mg PO x1 after 24h, then 10 mg PO qd; Info: for pts w/ SBP 100-120, start 2.5 mg PO qd x3 days, then may incr. to usual dose as tolerated
migraine prophylaxis (off-label)
- [20 mg PO qd]
- Start: 10 mg PO qd x1wk
renal dosing
- [HTN]
- CrCl 10-30: start 5 mg qd, max 40 mg/day; CrCl <10: start 2.5 mg qd, max 40 mg/day
- HD: start 2.5 mg qd, max 40 mg/day; no supplement after dialysis; PD: not defined
- [all other indications]
- CrCl <31: start 2.5 mg qd, max 40 mg/day
- HD: start 2.5 mg qd, max 40 mg/day; no supplement after dialysis; PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg
HTN
- [6 yo and older]
- Dose: 0.07-0.61 mg/kg/dose PO qd; Start: 0.07 mg/kg/dose PO qd up to 5 mg/day; Max: 0.61 mg/kg/day up to 40 mg/day
renal dosing
- [see below]
- CrCl <30: avoid use
- HD: not defined, consider adult renal dosing for guidance; PD: not defined
hepatic dosing
- [not defined]