Select a medication above to begin.
penicillin G potassium
generic
Adult Dosing .
Dosage forms: INJ
infections, bacterial
- [1-30 million units/day IM/IV divided q4-6h]
- Max: 30 million units/day; Info: dose, duration vary by infection type, severity
meningitis, meningococcal
- [24 million units/day IV divided q2-4h]
septicemia, meningococcal
- [24 million units/day IM/IV divided q2h]
neurosyphilis
- [18-24 million units/day IV via continuous infusion or divided q4h x10-14 days]
- Info: 1st-line agent
endocarditis
- [12-30 million units/day IV via continuous infusion or divided q4-6h x4-6wk]
- Info: dose, duration varies w/ infection severity, pathogen susceptibility, valve type, sx duration; may give w/ aminoglycoside gram positive synergy; refer to AHA guidelines
anthrax, systemic
- [4 million units IV q4h for at least 2wk]
- Info: for penicillin-susceptible B. anthracis incl. cutaneous infection w/ systemic involvement; not 1st-line agent; part of multi-drug regimen; switch to PO abx for post-exposure prophylaxis if inhalational exposure
pneumonia, community-acquired
- [2-4 million units IV q4-6h for at least 5 days]
- Info: for inpatient tx
Lyme dz (off-label)
- [18-24 million units/day IV divided q4h x14-21 days]
- Info: for neurologic dz; may switch to PO regimen when possible to complete course; not 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool
renal dosing
- [see below]
- CrCl 10-50: give usual divided dose x1, then give 50% usual divided dose q4-5h; CrCl <10: give usual divided dose x1, then give 50% usual divided dose q8-10h; Info: consider further dose decr. if both renal and hepatic impairment
- HD: give usual divided dose x1, then decr. usual divided dose by 50-80%, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose x1, then decr. usual divided dose by 50-80%; no supplement; Info: consider further dose decr. if both renal and hepatic impairment
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
infections, bacterial
- [neonates 0-7 days old]
- Dose: 50,000-100,000 units/kg/day IM/IV divided q12h; Info: dose, duration vary by infection type, severity
- [neonates >7 days old]
- Dose: 75,000-200,000 units/kg/day IM/IV divided q6-8h; Info: dose, duration vary by infection type, severity
- [infants/children]
- Dose: 100,000-400,000 units/kg/day IM/IV divided q4-6h; Info: dose, duration vary by infection type, severity
meningitis, Group B Streptococcal
- [neonates 0-7 days old]
- Dose: 250,000-450,000 units/kg/day IV divided q8h x14-21 days
- [neonates >7 days old]
- Dose: 450,000-500,000 units/kg/day IV divided q6h x14-21 days
- [infants/children]
- Dose: 450,000-500,000 units/kg/day IV divided q4-6h x14-21 days
meningitis, non-Group B Streptococcal
- [neonates 0-7 days old, <2 kg]
- Dose: 100,000 units/kg/day IV divided q12h; Info: duration varies by organism, infection severity
- [neonates 0-7 days old, >2 kg]
- Dose: 150,000 units/kg/day IV divided q8h; Info: duration varies by organism, infection severity
- [neonates >7 days old, <1.2 kg]
- Dose: 100,000 units/kg/day IV divided q12h; Info: duration varies by organism, infection severity
- [neonates >7 days old, 1.2-2 kg]
- Dose: 150,000 units/kg/day IV divided q8h; Info: duration varies by organism, infection severity
- [neonates >7 days old, >2 kg]
- Dose: 200,000 units/kg/day IV divided q6h; Info: duration varies by organism, infection severity
- [infants/children]
- Dose: 250,000-400,000 units/kg/day IV divided q4-6h; Max: 24 million units/day; Info: dose, duration vary by organism, infection severity
syphilis, congenital
- [neonates]
- Dose: 100,000 units/kg/day IV divided q12h x1st 7 days of life, then 150,000 units/kg/day IV divided q8h to complete 10 days total; Info: repeat entire course if >1 day missed; 1st-line agent
- [infants/children]
- Dose: 50,000 units/kg/dose IV q4-6h x10 days; Info: 1st-line agent
neurosyphilis
- [adolescents]
- Dose: 18-24 million units/day IV via continuous infusion or divided q4h x10-14 days; Info: 1st-line agent
endocarditis
- [200,000-300,000 units/kg/day IV divided q4h for at least 4wk]
- Max: 12-24 million units/day; Info: dose, duration varies w/ pathogen susceptibility, valve type; may give w/ gentamicin gram positive synergy; refer to AHA guidelines
anthrax, systemic
- [neonates >32 wk gestation]
- Dose: 200,000-400,000 units/kg/day IV divided q6-12h for at least 2wk; Info: for penicillin-susceptible B. anthracis incl. cutaneous infection w/ systemic involvement; part of multi-drug regimen; dose, frequency depend on gestational and post-natal age; switch to PO abx x60 days total if inhalational exposure
- [1 mo and older]
- Dose: 400,000 units/kg/day IV divided q4h for at least 2wk; Max: 4 million units/dose; Info: penicillin-susceptible B. anthracis incl. cutaneous infection w/ systemic involvement; part of multi-drug regimen; switch to PO abx x60 days total if inhalational exposure
pneumonia, community-acquired
- [100,000-250,000 units/kg/day IV divided q4-6h x10 days]
- Info: refer to IDSA guidelines
Lyme dz (off-label)
- [200,000-400,000 units/kg/day IV divided q4h x14-21 days]
- Max: 18-24 million units/day; Info: for neurologic dz; may switch to PO regimen when possible to complete course; not 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool
renal dosing
- [see below]
- CrCl 10-50: give usual divided dose x1, then decr. usual divided dose by 25%; CrCl <10: give usual divided dose x1, then decr. usual divided dose by 50-80%; Info: consider further dose decr. if both renal and hepatic impairment
- HD: give usual divided dose x1, then decr. usual divided dose by 50-80%, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose x1, then decr. usual divided dose by 50-80%; no supplement; Info: consider further dose decr. if both renal and hepatic impairment
hepatic dosing
- [not defined]