fluoxetine

Adult Dosing .

Dosage forms:  CAP: 10 mg, 20 mg, 40 mg; DR CAP: 90 mg; TAB: 10 mg, 20 mg, 60 mg; SOL: 20 mg per 5 mL

major depressive disorder

[immediate-release form]

Dose: 20-80 mg PO qam; Start: 20 mg PO qam, may incr. dose after several wk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

[delayed-release form]

Dose: 90 mg DR PO qwk; Start: 1wk after last dose of 20 mg PO qd; Info: for maintenance tx; taper dose gradually to D/C

major depressive disorder, tx-resistant

[combo w/ olanzapine]

Dose: 20-50 mg PO qpm; Start: 20 mg PO qpm; Max: 50 mg/day; Info: periodically reassess need for tx; taper dose gradually to D/C

obsessive-compulsive disorder

[20-60 mg PO qam]

Start: 20 mg PO qam, may incr. dose after several wk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

bulimia nervosa

[60 mg PO qam]

Info: may titrate dose to 60 mg/day over several days; taper dose gradually to D/C

panic disorder

[20 mg PO qam]

Start: 10 mg PO qam x1wk; Max: 60 mg/day; Info: taper dose gradually to D/C

premenstrual dysphoric disorder

[20 mg PO qd]

Max: 80 mg/day; Alt: 20 mg PO qd during luteal phase; Info: no proven benefit at doses >20 mg/day; taper dose gradually to D/C

bipolar I disorder, acute depressive

[combo w/ olanzapine]

Dose: 20-50 mg PO qpm; Start: 20 mg PO qpm; Max: 50 mg/day; Info: periodically reassess need for tx; taper dose gradually to D/C

cataplexy (off-label)

[20-60 mg PO qam]

Start: 20 mg PO qam, may incr. dose qwk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: decr. usual dose or frequency, amount not defined

Peds Dosing .

Dosage forms:  CAP: 10 mg, 20 mg, 40 mg; TAB: 10 mg, 20 mg, 60 mg; SOL: 20 mg per 5 mL

major depressive disorder

[8-18 yo]

Dose: 10-20 mg PO qd; Start: 10 mg PO qd x1wk; Info: slower titration in lower wt pts; may incr. dose up to 60 mg/day in severe dz or higher wt pts; taper dose gradually to D/C

obsessive-compulsive disorder

[7-17 yo]

Dose: 20-60 mg PO qd; Start: 10 mg PO qd, may incr. by 10 mg/day q14 days; Info: slower titration, max 20-30 mg/day in lower wt pts; taper dose gradually to D/C

bipolar I disorder, acute depressive

[combo w/ olanzapine, 10-17 yo]

Dose: 20-50 mg PO qpm; Start: 20 mg PO qpm; Max: 50 mg/day; Info: slower titration in lower wt pts; periodically reassess need for tx; taper dose gradually to D/C

bulimia nervosa (off-label)

[12 yo and older]

Dose: 20-60 mg PO qd; Start: 20 mg PO qam x3 days, may incr. by 20 mg/day q3 days; Max: 60 mg/day; Info: slower titration in lower wt pts; taper dose gradually to D/C

post-traumatic stress disorder (off-label)

[7-17 yo]

Dose: 10-20 mg PO qd; Start: 10 mg PO qd x7-14 days; Info: slower titration in lower wt pts; taper dose gradually to D/C

social anxiety disorder (off-label)

[5 yo and older]

Dose: 20 mg PO qd; Start: 5 mg PO qd x1wk, then incr. to 10 mg PO qd x1wk, then incr. to 20 mg PO qd; Max: 60 mg/day; Info: slower titration in lower wt pts; taper dose gradually to D/C

cataplexy (off-label)

[5 yo and older]

Dose: 10-40 mg PO qd; Start: 10 mg PO qd, may incr. dose by 10 mg/day qwk; Max: 60 mg/day; Info: slower titration in lower wt pts; taper dose gradually to D/C

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: decr. usual dose or frequency, amount not defined