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nabumetone
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 500 mg, 750 mg
osteoarthritis
- [1000-2000 mg/day PO divided qd-bid]
- Start: 1000 mg PO qd; Max: 2000 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
rheumatoid arthritis
- [1000-2000 mg/day PO divided qd-bid]
- Start: 1000 mg PO qd; Max: 2000 mg/day; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [1000-2000 mg/day PO divided qd-bid]
- Max: 2000 mg/day x7-14 days; Info: use lowest effective dose, shortest effective tx duration; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl 30-49: start 750 mg qd, max 1500 mg/day; CrCl <30: avoid use; Alt: start 500 mg qd, max 1000 mg/day; advanced renal dz: avoid use
- HD: avoid use; Alt: 1000 mg qd; no supplement after dialysis; PD: avoid use
hepatic dosing
- [see below]
- mild-moderate impairment: not defined; severe impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.