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Omnipaque
iohexol
Black Box Warnings .
Risk w/ Inadvertent Intrathecal Administration
inadvertent intrathecal administration of 140 mg per mL or 350 mg per mL INJ form may cause death, convulsions, seizures, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, rhabdomyolysis, hyperthermia, and brain edema
Adult Dosing .
Dosage forms: SOL: 9 mg per mL, 12 mg per mL; INJ: 140 mg per mL, 180 mg per mL, 240 mg per mL, 300 mg per mL, 350 mg per mL
Special Note
- [strength clarification]
- Info: all strengths expressed as iodine concentration
myelography
- [lumbar]
- Dose: 10-17 mL (180 mg per mL) intrathecally x1; Alt: 7-12.5 mL (240 mg per mL) intrathecally x1
- [thoracic]
- Dose: 6-12.5 mL (240 mg per mL) intrathecally x1; Alt: 6-10 mL (300 mg per mL) intrathecally x1
- [cervical, via C1-2 injection]
- Dose: 7-10 mL (180 mg per mL) intrathecally x1; Alt: 6-12.5 mL (240 mg per mL) intrathecally x1; 4-10 mL (300 mg per mL) intrathecally x1
- [cervical, via lumbar injection]
- Dose: 6-12.5 mL (240 mg per mL) intrathecally x1; Alt: 6-10 mL (300 mg per mL) intrathecally x1
- [total columnar]
- Dose: 6-12.5 mL (240 mg per mL) intrathecally x1; Alt: 6-10 mL (300 mg per mL) intrathecally x1
computed tomography cisternography
- [10-17 mL (180 mg per mL) intrathecally x1]
- Alt: 7-12.5 mL (240 mg per mL) intrathecally x1
cardiac ventriculography
- [30-60 mL (350 mg per mL) intra-arterially x1]
- Max: cumulative dose 250 mL; Info: may combine w/ selective coronary arteriography
selective coronary arteriography
- [3-14 mL (350 mg per mL) intra-arterially x1]
- Max: cumulative dose 250 mL; Info: may combine w/ cardiac ventriculography
aortography and selective visceral arteriography
- [aortic arch or ascending aorta]
- Dose: 50-80 mL (300 mg per mL or 350 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL (300 mg per mL); cumulative dose 250 mL (350 mg per mL)
- [abdominal aorta and branches]
- Dose: 30-60 mL (300 mg per mL or 350 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL (300 mg per mL); cumulative dose 250 mL (350 mg per mL)
- [renal arteries]
- Dose: 5-15 mL (300 mg per mL or 350 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL (300 mg per mL); cumulative dose 250 mL (350 mg per mL)
aortography
- [20-75 mL (350 mg per mL) intra-arterially x1]
- Max: cumulative dose 250 mL; Info: for aortic root and arch study when used alone
cerebral arteriography
- [common carotid artery]
- Dose: 6-12 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL
- [internal carotid artery]
- Dose: 8-10 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL
- [external carotid artery]
- Dose: 6-9 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL
- [vertebral artery]
- Dose: 6-10 mL (300 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL
peripheral arteriography
- [aortofemoral runoffs]
- Dose: 30-90 mL (300 mg per mL) intra-arterially x1; Alt: 20-70 mL (350 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL (300 mg per mL); cumulative dose 250 mL (350 mg per mL)
- [selective arteriograms]
- Dose: 10-60 mL (300 mg per mL) intra-arterially x1; Alt: 10-30 mL (350 mg per mL) intra-arterially x1; Max: cumulative dose 290 mL (300 mg per mL); cumulative dose 250 mL (350 mg per mL)
digital subtraction angiography
- [intra-arterial route, aorta]
- Dose: 20-45 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [intra-arterial route, carotid artery]
- Dose: 5-10 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [intra-arterial route, femoral artery]
- Dose: 9-20 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [intra-arterial route, vertebral artery]
- Dose: 4-10 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [intra-arterial route, renal arteries]
- Dose: 6-12 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [intra-arterial route, other aorta branches incl. subclavian, axillary, innominate, iliac]
- Dose: 8-25 mL (140 mg per mL) intra-arterially x1; Max: cumulative dose 250 mL
- [IV route]
- Dose: 30-50 mL (350 mg per mL) IV x1; Max: cumulative dose 250 mL; Info: may require >3 doses
excretory urography
- [0.6-1.2 mL/kg/dose (300 mg per mL or 350 mg per mL) IV x1]
- Max: 102 mL/dose
computed tomography
- [head]
- Dose: 120-250 mL (240 mg per mL) IV x1: Alt: 70-150 mL (300 mg per mL) IV x1; 80 mL (350 mg per mL) IV x1
- [body]
- Dose: 50-200 mL (300 mg per mL) IV x1; Alt: 60-100 mL (350 mg per mL) IV x1
- [abdomen and pelvis]
- Dose: 500-1000 mL (9 mg per mL or 12 mg per mL) PO x1, then 100-150 mL (300 mg per mL) IV x1; Info: may dilute 240 mg per mL, 300 mg per mL, or 350 mg per mL INJ solution for PO use, see pkg insert; give IV dose w/in 40min after PO dose
peripheral venography
- [20-150 mL (240 mg per mL) IV x1 per leg]
- Alt: 40-100 mL (300 mg per mL) IV x1 per leg
radiography, GI
- [50-100 mL (350 mg per mL) PO x1]
- Info: give undiluted INJ solution PO
arthrography
- [knee]
- Dose: 5-15 mL (240 mg per mL or 300 mg per mL) intra-articularly x1; Alt: 5-10 mL (350 mg per mL) intra-articularly x1
- [shoulder]
- Dose: 10 mL (300 mg per mL) intra-articularly x1
- [temporomandibular]
- Dose: 0.5-1 mL (300 mg per mL) intra-articularly x1
endoscopic retrograde pancreatography
- [10-50 mL (240 mg per mL) intraductally x1]
endoscopic retrograde cholangiopancreatography
- [10-50 mL (240 mg per mL) intraductally x1]
herniography
- [50 mL (240 mg per mL) intraperitoneally x1]
hysterosalpingography
- [15-20 mL (240 mg per mL or 300 mg per mL) intrauterinely x1]
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SOL: 9 mg per mL, 12 mg per mL; INJ: 140 mg per mL, 180 mg per mL, 240 mg per mL, 300 mg per mL, 350 mg per mL
Special Note
- [strength clarification]
- Info: all strengths expressed as iodine concentration
myelography
- [2 wk-2 mo]
- Dose: 2-4 mL (180 mg per mL) intrathecally x1
- [3-35 mo]
- Dose: 4-8 mL (180 mg per mL) intrathecally x1
- [3-6 yo]
- Dose: 5-10 mL (180 mg per mL) intrathecally x1
- [7-12 yo]
- Dose: 5-12 mL (180 mg per mL) intrathecally x1
- [13 yo and older]
- Dose: 6-15 mL (180 mg per mL) intrathecally x1
computed tomography cisternography
- [2 wk-2 mo]
- Dose: 2-4 mL (180 mg per mL) intrathecally x1
- [3-35 mo]
- Dose: 4-8 mL (180 mg per mL) intrathecally x1
- [3-6 yo]
- Dose: 5-10 mL (180 mg per mL) intrathecally x1
- [7-12 yo]
- Dose: 5-12 mL (180 mg per mL) intrathecally x1
- [13 yo and older]
- Dose: 6-15 mL (180 mg per mL) intrathecally x1
cardiac ventriculography
- [1.5-2 mL/kg/dose (300 mg per mL) intra-arterially x1]
- Max: cumulative dose 6 mL/kg up to 290 mL; Alt: 1-1.5 mL/kg/dose (350 mg per mL) intra-arterially x1, max cumulative dose 5 mL/kg up to 250 mL
pulmonary angiography
- [1 mL/kg/dose (350 mg per mL) intra-arterially x1]
- Max: cumulative dose 5 mL/kg up to 250 mL
aortography
- [1 mL/kg/dose (350 mg per mL) intra-arterially]
- Max: cumulative dose 5 mL/kg up to 250 mL
excretory urography
- [0.5-3 mL/kg/dose (300 mg per mL) IV x1]
- Max: 116 mL/dose; Info: may combine w/ voiding cystourethrography
computed tomography
- [head and body]
- Dose: 1-2 mL/kg/dose (240 mg per mL or 300 mg per mL) IV x1; Max: 3 mL/kg/dose up to 116 mL
- [abdomen and pelvis, <3 yo]
- Dose: 180-750 mL (9 mg per mL or 12 mg per mL) PO x1, then 1-2 mL/kg/dose (240 mg per mL or 300 mg per mL) IV x1; Max: 5 g/dose PO; 3 mL/kg/dose up to 116 mL IV; Info: may dilute 240 mg per mL, 300 mg per mL, or 350 mg per mL INJ solution for PO use, see pkg insert; give IV dose w/in 60min after PO dose
- [abdomen and pelvis, 3 yo and older]
- Dose: 180-750 mL (9 mg per mL or 12 mg per mL) PO x1, then 1-2 mL/kg/dose (240 mg per mL or 300 mg per mL) IV x1; Max: 10 g/dose PO; 3 mL/kg/dose up to 116 mL IV; Info: may dilute 240 mg per mL, 300 mg per mL, or 350 mg per mL INJ solution for PO use, see pkg insert; give IV dose w/in 60min after PO dose
radiography, GI
- [<3 mo]
- Dose: 5-30 mL (180 mg per mL) PO x1; Alt: up to 300 mL (180 mg per mL) PR x1; Info: give undiluted INJ solution PO/PR
- [3 mo-3 yo]
- Dose: up to 60 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PO x1; Alt: up to 300 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PR x1; Info: give undiluted INJ solution PO/PR
- [4-10 yo]
- Dose: up to 80 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PO x1; Alt: up to 300 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PR x1; Info: give undiluted INJ solution PO/PR
- [>10 yo]
- Dose: up to 100 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PO x1; Alt: up to 300 mL (180 mg per mL or 240 mg per mL or 300 mg per mL) PR x1; Info: give undiluted INJ solution PO/PR
voiding cystourethrography
- [50-300 mL (100 mg per mL) intracavitarily x1]
- Alt: 50-600 mL (50 mg per mL) intracavitarily x1; Info: dilute 240 mg per mL, 300 mg per mL, or 350 mg per mL INJ solution to conc. 50-100 mg per mL; may combine w/ excretory urography
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]