Crexont

Adult Dosing .

Dosage forms:  ER CAP: 35 mg/140 mg, 52.5 mg/210 mg, 70 mg/280 mg, 87.5 mg/350 mg

Special Note

[formulation clarification]

Info: carbidopa/levodopa ER cap not interchangeable w/ ER tab; do not substitute on a mg to mg basis; may interchange w/ other ER cap at approx. mg to mg basis

parkinsonism

[levodopa-naive pts]

Dose: individualize dose PO bid; Start: 35 mg/140 mg PO bid x3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa <500 mg/day, most frequent single-dose 100 mg]

Dose: individualize dose PO bid; Start: 70 mg/280 mg PO bid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa <500 mg/day, most frequent single-dose 150 mg]

Dose: individualize dose PO bid; Start: 105 mg/420 mg PO bid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa <500 mg/day, most frequent single-dose 200 mg]

Dose: individualize dose PO bid; Start: 140 mg/560 mg PO bid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa >500 mg/day, most frequent single-dose 100 mg]

Dose: individualize dose PO tid; Start: 70 mg/280 mg PO tid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa >500 mg/day, most frequent single-dose 150 mg]

Dose: individualize dose PO tid; Start: 105 mg/420 mg PO tid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa >500 mg/day, most frequent single-dose 200 mg]

Dose: individualize dose PO tid; Start: 140 mg/560 mg PO tid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

[conversion from IR levodopa >500 mg/day, most frequent single-dose >200 mg]

Dose: individualize dose PO tid; Start: 175 mg/700 mg PO tid x1-3 days; Max: 525 mg/2100 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. up to qid if needed; use lowest effective dose; do not open cap; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.