Gomekli

Adult Dosing .

Dosage forms:  CAP: 1 mg, 2 mg; TAB: 1 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

neurofibromatosis, type 1

[BSA 1.05-1.49 m^2]

Dose: 3 mg PO bid on days 1-21 of 28-day cycle; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

[BSA >1.5 m^2]

Dose: 4 mg PO bid on days 1-21 of 28-day cycle; Max: 4 mg/dose; 8 mg/day; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined

Peds Dosing .

Dosage forms:  CAP: 1 mg, 2 mg; TAB: 1 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

neurofibromatosis, type 1

[2 yo and older, BSA 0.4-0.69 m^2]

Dose: 1 mg PO bid on days 1-21 of 28-day cycle; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

[2 yo and older, BSA 0.7-1.04 m^2]

Dose: 2 mg PO bid on days 1-21 of 28-day cycle; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

[2 yo and older, BSA 1.05-1.49 m^2]

Dose: 3 mg PO bid on days 1-21 of 28-day cycle; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

[2 yo and older, BSA >1.5 m^2]

Dose: 4 mg PO bid on days 1-21 of 28-day cycle; Max: 4 mg/dose; 8 mg/day; Info: for pts w/ symptomatic plexiform neurofibromas not amenable to complete resection; do not open/crush/chew cap

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined