Vyalev

Adult Dosing .

Dosage forms:  INJ: 12 mg/240 mg per mL

Special Note

[dosing clarification]

Info: dose based on foslevodopa component

Parkinson dz, advanced

[optional loading dose]

Dose: [foslevodopa dose = usual 1st morning dose of oral IR levodopa (mg) x 1.3] via SC infusion x1; Start: immediately before continuous infusion; Max: 720 mg/dose; Info: for pts starting tx during off-period or if tx interrupted >3h; may alternatively give usual 1st morning dose of oral IR carbidopa/levodopa

[continuous infusion]

Dose: individualize dose via SC infusion over 16-24h/day; Start: [foslevodopa dose = total daily levodopa dose (mg) x 1.3] via SC infusion over 16-24h/day, then may adjust dose by 2.4 mg/h; Max: 3525 mg/day; Info: see pkg insert to determine total daily levodopa dose and for extra dose options; taper dose gradually to D/C

renal impairment

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic impairment

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.