Sinemet

Adult Dosing .

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

parkinsonism

[individualize dose PO tid-qid]

Start: 10 mg/100 mg PO tid-qid or 25 mg/100 mg PO tid, may incr. by 1 tab/day q1-2 days; Max 200 mg/2000 mg/day; Info: 70-100 mg/day carbidopa needed to saturate periph. dopa decarboxylase and minimize adverse effects; taper dose gradually to D/C

sleep-related eating disorder (off-label)

[25 mg/100 mg PO qhs]

restless legs syndrome (off-label)

[25 mg/100 mg PO qhs prn]

Max: 50 mg/200 mg/day; Info: for intermittent sx; may start 12.5 mg/50 mg PO qhs x1-2 days; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

dystonia, generalized (off-label)

[2 yo and older]

Dose: individualize dose PO bid-tid; Start: 12.5 mg/50 mg PO bid, may incr. by 0.5-1 tab/day q3 days; Max: 20 mg/kg/day levodopa; Info: taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]