Select a medication above to begin.
Sporanox
itraconazole
Black Box Warnings .
CHF
should not use in onychomycosis pts if ventricular dysfunction such as CHF or CHF hx; negative inotropic effects; D/C if CHF s/sx occur
Drug Interactions
coadministration is contraindicated w/ methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, dihydroergotamine, ergotamine, methylergonovine, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, finerenone, voclosporin, and, in subjects w/ varying degrees of renal or hepatic impairment, colchicine, fesoterodine, solifenacin; eliglustat coadministration contraindicated in poor or intermediate CYP2D6 metabolizers and in pts taking strong or moderate CYP2D6 inhibitors; venetoclax coadministration contraindicated in pts w/ CLL/SLL during venetoclax dose initiation and ramp-up phase; elevated plasma concentrations of these drugs may occur, leading to increased or prolonged pharmacologic effects and/or adverse rxns incl. for some drugs QT prolongation and ventricular tachyarrhythmias incl. torsades de pointes, a potentially fatal arrhythmia
Adult Dosing .
Dosage forms: CAP: 100 mg; SOL: 10 mg per mL
Special Note
- [formulation clarification]
- Info: not interchangeable w/ itraconazole 65 mg caps; do not substitute on a mg to mg basis
infections, fungal
- [200 mg cap PO qd-bid]
- Start: 200 mg cap PO tid x3 days for life-threatening infections; Max: 600 mg/day; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps w/ food
onychomycosis, fingernails
- [200 mg cap PO bid x7 days, off x21 days]
- Info: for immunocompetent pts; give x2 courses (8wk total); confirm dx prior to tx; give caps w/ food
onychomycosis, toenails
- [200 mg cap PO qd x12wk]
- Info: for immunocompetent pts; confirm diagnosis prior to tx; give caps w/ food
candidiasis, oropharyngeal
- [20 mL PO qd x1-2wk]
- Alt: 10 mL PO bid x2-4wk; Info: for fluconazole-refractory dz; swish and swallow; give oral solution w/o food
candidiasis, esophageal
- [20 mL PO qd x14-21 days]
- Info: for fluconazole-refractory dz; swish and swallow; give oral solution w/o food
blastomycosis
- [200 mg cap PO qd]
- Max: 400 mg/day; Info: for pulmonary and extrapulmonary dz; may incr. by 100 mg if no improvement; divide dose bid if >200 mg/day; give caps w/ food; start 200 mg PO tid x3 days if life-threatening infection, max 600 mg/day
histoplasmosis
- [200 mg cap PO qd]
- Max: 400 mg/day; Info: may incr. by 100 mg if no improvement; divide dose bid if >200 mg/day; give caps w/ food; start 200 mg PO tid x3 days if life-threatening infection, max 600 mg/day
aspergillosis, invasive
- [20 mL PO q12h]
- Alt: 200-400 mg cap PO qd; Info: for salvage tx; divide dose bid if >200 mg/day; oral solution preferred; give oral solution w/o food, caps w/ food; caps and oral solution not bioequivalent; oral solution w/ higher bioavailability; caution advised if switching between products
superficial mycoses (off-label)
- [100-200 mg cap PO qd-bid]
- Max: 600 mg/day; Info: dose, duration varies by indication; divide dose bid if >200 mg/day; give caps w/ food
coccidioidomycosis (off-label)
- [200 mg cap PO q12h]
- Info: give caps w/ food
meningitis, coccidioidal (off-label)
- [200 mg cap PO q12h]
- Info: cont. for lifetime; give caps w/ food
sporotrichosis, cutaneous/lymphocutaneous (off-label)
- [200 mg PO qd]
- Info: may incr. to 200 mg PO bid; continue until 2-4wk after lesions resolved; oral solution preferred; give caps w/ food, oral solution w/o food; caps and oral solution not bioequivalent; oral solution w/ higher bioavailability; caution advised if switching between products
renal dosing
- [see below]
- CrCl <10: decr. usual dose by 50%
- HD: 100 mg q12-24h; no supplement after dialysis; PD: 100 mg q12-24h; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 100 mg; SOL: 10 mg per mL
Special Note
- [formulation clarification]
- Info: not interchangeable w/ itraconazole 65 mg caps; do not substitute on a mg to mg basis
infections, fungal (off-label)
- [5 mg/kg/day PO divided qd-bid]
- Max: 10 mg/kg/day or 600 mg/day; Alt: 100 mg PO qd; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps w/ food, oral solution w/o food; caps and oral solution not bioequivalent; oral solution w/ higher bioavailability; caution advised if switching between products
superficial mycoses (off-label)
- [5 mg/kg/day PO divided qd-bid]
- Max: 10 mg/kg/day or 600 mg/day; Alt: 100 mg PO qd; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps w/ food, oral solution w/o food; caps and oral solution not bioequivalent; oral solution w/ higher bioavailability; caution advised if switching between products
sporotrichosis, cutaneous/lymphocutaneous (off-label)
- [children]
- Dose: 6-10 mg/kg/day PO divided qd-bid; Max: 400 mg/day; Info: continue until 2-4wk after lesions resolved; oral solution preferred; give caps w/ food, oral solution w/o food; caps and oral solution not bioequivalent; oral solution w/ higher bioavailability; caution advised if switching between products
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance