Suprax

Adult Dosing .

Dosage forms:  CAP: 400 mg; TAB: 400 mg; CHEWABLE: 100 mg, 200 mg; SUSP: 100 mg per 5 mL, 200 mg per 5 mL, 500 mg per 5 mL

infections, bacterial

[400 mg PO qd]

Alt: 200 mg PO bid; Info: duration varies by infection site/severity

chronic bronchitis, acute bacterial exacerbation

[400 mg PO qd x10 days]

Alt: 200 mg PO bid x10 days

pneumonia, community-acquired

[400 mg PO qd for at least 5 days]

Alt: 200 mg PO bid for at least 5 days

UTI, uncomplicated

[400 mg PO qd x3-7 days]

Alt: 200 mg PO bid x3-7 days

infections, uncomplicated gonococcal

[800 mg PO x1]

Info: for infections of cervix, urethra, rectum; not 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts

renal dosing

[capsule]

CrCl >60: no adjustment; CrCl <60: not defined

HD/PD: not defined

[oral or chewable tab]

CrCl >60: no adjustment; CrCl 21-59: not defined; CrCl <21: 200 mg qd

HD: not defined; PD: 200 mg qd; no supplement

[100 mg per 5 mL susp]

CrCl 21-59: 260 mg qd; CrCl <21: 172 mg qd

HD: 260 mg qd; no supplement after dialysis; PD: 172 mg qd; no supplement

[200 mg per 5 mL susp]

CrCl 21-59: 260 mg qd; CrCl <21: 176 mg qd

HD: 260 mg qd; no supplement after dialysis; PD: 176 mg qd; no supplement

[500 mg per 5 mL susp]

CrCl 21-59: 260 mg qd; CrCl <21: 180 mg qd

HD: 260 mg qd; no supplement after dialysis; PD: 180 mg qd; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 400 mg; TAB: 400 mg; CHEWABLE: 100 mg, 200 mg; SUSP: 100 mg per 5 mL, 200 mg per 5 mL, 500 mg per 5 mL

infections, bacterial

[6 mo-12 yo, <45 kg]

Dose: 8 mg/kg/day PO divided qd-bid; Info: duration varies by infection site/severity

[6 mo-12 yo, >45 kg]

Dose: 400 mg PO qd; Alt: 200 mg PO bid; Info: duration varies by infection site/severity

[>12 yo]

Dose: 400 mg PO qd; Alt: 200 mg PO bid; Info: duration varies by infection site/severity

chronic bronchitis, acute bacterial exacerbation

[6 mo-11 yo]

Dose: 8 mg/kg/dose PO q24h x10 days

[12 yo and older]

Dose: 400 mg PO qd x10 days; Alt: 200 mg PO bid x10 days

infections, uncomplicated gonococcal

[adolescents]

Dose: 800 mg PO x1; Info: for infections of cervix, urethra, rectum; not 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts

UTI

[6 mo-11 yo]

Dose: 8 mg/kg/dose PO q24h x7-14 days; Info: duration varies w/ infection type, severity

[12 yo and older]

Dose: 400 mg PO qd x7 days; Alt: 200 mg PO bid x7 days

pneumonia, community-acquired (off-label)

[8 mg/kg/day PO divided q12-24h x10 days]

Info: refer to IDSA guidelines

renal dosing

[adjust dose amount]

CrCl 21-60: decr. usual divided dose by 35%; CrCl <21: decr. usual divided dose by 55%

HD: decr. usual divided dose by 35%; no supplement after dialysis; PD: decr. usual divided dose by 55%; no supplement

hepatic dosing

[not defined]