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trimipramine
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: CAP: 25 mg, 50 mg, 100 mg
depression
- [inpatient]
- Dose: 100-200 mg PO qhs; Start: 100 mg/day PO in divided doses; Max: 300 mg/day; Info: may give total daily dose qhs once stable; in elderly pts start 50 mg/day PO in divided doses, max 100 mg/day; taper dose gradually to D/C
- [outpatient]
- Dose: 50-150 mg PO qhs; Start: 75 mg/day PO in divided doses; Max: 200 mg/day; Info: may give total daily dose qhs once stable; in elderly pts start 50 mg/day PO in divided doses, max 100 mg/day; taper dose gradually to D/C
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.