Syprine

Adult Dosing .

Dosage forms:  CAP: 250 mg

Special Note

[formulation clarification]

Info: trientine hydrochloride not interchangeable w/ trientine tetrahydrochloride; do not substitute on a mg to mg basis

[strength clarification]

Info: 250 mg trientine hydrochloride = 167 mg trientine base; doses expressed as trientine hydrochloride

Wilson dz

[750-1250 mg/day PO divided bid-qid]

Max: 2000 mg/day; Info: for pts intolerant to penicillamine; dose adjustment may be needed during pregnancy and/or postpartum; give on empty stomach, at least 1h before or 2h after food or milk; do not open cap

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 250 mg

Special Note

[formulation clarification]

Info: trientine hydrochloride not interchangeable w/ trientine tetrahydrochloride; do not substitute on a mg to mg basis

[strength clarification]

Info: 250 mg trientine hydrochloride = 167 mg trientine base; doses expressed as trientine hydrochloride

Wilson dz

[<13 yo]

Dose: 20 mg/kg/day PO divided bid-tid; Max: 1500 mg/day; Info: for pts intolerant to penicillamine; give on empty stomach, at least 1h before or 2h after food or milk; do not open cap

[13 yo and older]

Dose: 750-1250 mg/day PO divided bid-qid; Max: 2000 mg/day; Info: for pts intolerant to penicillamine; give on empty stomach, at least 1h before or 2h after food or milk; do not open cap

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]