acetazolamide

Adult Dosing .

Dosage forms:  ER CAP: 500 mg; TAB: 125 mg, 250 mg; INJ: various

glaucoma, open-angle

[125-250 mg PO bid-qid]

Alt: 500 mg ER PO bid; 125-250 mg IV bid-qid; Info: doses >1 g/day rarely more effective

glaucoma, acute angle-closure

[125-250 mg PO/IV q4h]

Start: 500 mg PO x1; Alt: 500 mg ER PO bid; Info: for preop use; doses >1 g/day rarely more effective

glaucoma, secondary

[250 mg PO/IV q4h]

Alt: 500 mg ER PO bid; Info: may decr. to 250 mg PO/IV q12h for short-term tx; doses >1 g/day rarely more effective

altitude sickness prevention

[125 mg PO bid]

Start: 24h before or on day of ascent; Alt: 500 mg ER PO qd-bid; Info: D/C 2-3 days after peak arrival or upon descent

altitude sickness tx

[250 mg PO bid]

edema, heart failure-associated

[250-375 mg PO/IV qod-qd]

Start: 250-375 mg PO/IV qd; Info: give in morning; qd tx failure may require qod dosing

edema, drug-induced

[250-375 mg PO/IV qam x1-2 days, then off x1 day]

seizure disorder

[375-1000 mg/day PO divided bid-qid]

Start: 250 mg PO qd if w/ other anticonvulsants; Info: for absence and generalized seizure disorders

pseudotumor cerebri (off-label)

[1-2 g/day PO/IV divided bid-qid]

Start: 500 mg PO/IV bid; Max: 4 g/day; Alt: 500-1000 mg ER PO bid

urinary alkalinization (off-label)

[5 mg/kg/dose IV bid-tid prn]

Alt: 5 mg/kg/dose PO bid-tid prn

renal dosing

[see below]

marked renal dz/impairment: contraindicated

HD/PD: not defined

hepatic dosing

[see below]

significant impairment/cirrhosis: contraindicated

Peds Dosing .

Dosage forms:  TAB: 125 mg, 250 mg; INJ: various

seizure disorder

[8-30 mg/kg/day PO divided bid-qid]

Max: 1 g/day; Info: for absence and generalized seizure disorders

glaucoma, open-angle (off-label)

[8-30 mg/kg/day PO divided q6-8h]

Alt: 20-40 mg/kg/day IV divided q6h; Max: 1 g/day

glaucoma, acute angle-closure (off-label)

[20-40 mg/kg/day IV divided q6h]

Max: 1 g/day; Info: for preop use

glaucoma, secondary (off-label)

[20-40 mg/kg/day IV divided q6h]

Max: 1 g/day

altitude sickness prevention (off-label)

[2.5 mg/kg/dose PO q12h]

Start: 24h before or on day of ascent; Max: 125 mg/dose; Info: D/C 2-3 days after peak arrival or upon descent

altitude sickness tx (off-label)

[2.5 mg/kg/dose PO q12h]

Max: 250 mg/dose

edema, heart failure-associated (off-label)

[5 mg/kg/dose PO/IV qod-qd]

Start: 5 mg/kg/dose PO/IV qd x2 days; Info: give in morning; qd tx failure may require qod dosing

edema, drug-induced (off-label)

[5 mg/kg/dose PO/IV qam x1-2 days, then off x1 day]

hydrocephalus (off-label)

[20 mg/kg/day PO/IV divided q6-8h]

Max: 100 mg/kg/day; 2 g/day; Info: may incr. by 25 mg/kg/day qd

pseudotumor cerebri (off-label)

[40-100 mg/kg/day PO/IV divided q6-8h]

Start: 25 mg/kg/day PO/IV divided q6-8h; Max: 2 g/day

urinary alkalinization (off-label)

[5 mg/kg/dose IV bid-tid prn]

Alt: 5 mg/kg/dose PO bid-tid prn

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[see below]

significant impairment/cirrhosis: contraindicated